Involvement of Molecular Mechanism and Biological Activities of Pemirolast: A
Therapeutic Review

Vivek      Singh; Swamita      Arora; Wasim      Akram; Sanjar      Alam; Lovely      Kumari; Neeraj      Kumar; Bikash      Kumar; Santosh      Kumar; Mohit      Agrawal; Manmohan      Singhal; Shivendra      Kumar; Shubham      Singh; Kuldeep      Singh; Sunam      Saha; Vivek      Dwivedi

doi:10.2174/0102506882308410240607053814

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Abstract

This review paper aims to investigate the therapeutic benefits of pemirolast across different medical conditions, including asthma, allergic rhinitis, cancer, conjunctivitis, etc. The prevalence of allergic conditions has risen in recent decades, primarily attributed to environmental factors. This paper explores the role of pemirolast in managing and mitigating these diseases, shedding light on its potential applications in the context of evolving environmental influences.

This review paper investigates the diverse biological activities exhibited by pemirolast, encompassing its roles as an antimicrobial, analgesic, antiviral, anti-inflammatory, antioxidant, antihistamine, mast cell stabilizer, anti-tubercular, anticancer, anti-asthmatic, anti-malarial, diuretic, antianxiety, and antifungal agent. The positive outcomes of pemirolast application in various diseases are highlighted, showcasing its potential across a spectrum of medical conditions.

The pharmacological impact of pemirolast extends to diverse inflammatory mediators, enzymes, and hormones associated with various diseases. Pemirolast demonstrates inhibitory effects on key elements such as eosinophil activation, histamine, leukotriene, IgE, mast cells, basophils, prostaglandin, interleukin, T-helper cells, macrophage T-cells, neutrophils, tryptase, T-lymphocytes, interferons I-III, Amyloid β (Aβ) peptide, dsRNA transcription, GABA, dopamine, serotonin, and norepinephrine. This comprehensive exploration underscores pemirolast inhibitory actions across disorders, emphasizing its potential therapeutic relevance in diverse pathological conditions.

This review paper illuminates pemirolast potassium's versatile biological and therapeutic applications across various diseases. The potential synergies of combining pemirolast with buspirone, ritanserin, theophylline, and capreomycin are explored, showcasing its ability to elicit beneficial responses in addressing diverse ailments.

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DOI https://dx.doi.org/10.2174/0102506882308410240607053814	Print ISSN 0250-6882
Publisher Name Bentham Science Publisher	Online ISSN 0250-6882

New Emirates Medical Journal

Involvement of Molecular Mechanism and Biological Activities of Pemirolast: A Therapeutic Review

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