A Review of Traditional Anthelmintic Approaches: Exploring Medicinal
Plants and Polyherbal Formulations for Effective and Safe Gastrointestinal
Parasite Treatment

Arzoo      Pannu; Parina      Kumari
doi:10.2174/0122113525304411240528074154
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Abstract

Gastrointestinal parasites have become the most common reason for infection in humans, affecting many people in the world. Helminthic infections pose a large threat to public health in developing countries. The most common parasites of helminths in humans are whipworms(Trichuristrichiura), roundworms(Ascarislumbricoides), tapeworms(Taenia solium), and hookworms (Ancylostoma duodenale and Necator americanus). In the current scenario, synthetic medicines are found to be effective in curing the infection but these medicines produce side-effects that impair the effectiveness of the treatment. Fortunately, in the traditional system of medicines various medicinal plants have been mentioned for their anthelmintic activities, which are relatively free from side effects and are used by ethnic groups worldwide. In the 21st century, an ideal anthelmintic agent should be cost-effective, provide a high percentage of cure, have a broad spectrum of action, and free from toxicity to the host. However, none of the modern marketed medicines fulfill these requirements. Therefore, in this view, several researchers have undertaken various in vivo and in vitro studies to scrutinize folklore medicinal plants for their proclaimed anthelmintic activity. In thisreview, we have summarized some scientifically approved polyherbal formulations and Indian medicinal plants documented for anthelmintic activity, which can be further studied to achieve novel herbal lead molecules from them by isolating their principal compounds.
[1]
Burkhart, CN; Burkhart, CG Assessment of frequency, transmission, and genitourinary complications of enterobiasis (pinworms). Intern jou of derma.,  2005, 44(10), 837-840.

[2]
Mengistu, B; Liyew, EF; Chernet, M; Tasew, G; Maddren, R; Collyer, B; Anjulo, U; Tamiru, A; Forbes, K; Mehari, Z; Deribe, K Soiltransmitted helminth (STH) infections in the Wolaita zone in Southern Ethiopia. Mid-stage evaluation of the Geshiyaro project and progress towards the interruption of transmission.,  2024, 1, 1-25.

[3]
Ramlal, A.; Nautiyal, A.; Kumar, J.; Mishra, V.; Sogan, N.; Nasser, B.; Singab, A. Botanicals against some important nematodal diseases: Ascariasis and hookworm infections. Saudi J. Biol. Sci.,  2023, 30(11), 103814.
 [http://dx.doi.org/10.1016/j.sjbs.2023.103814] [PMID: 37841664]

[4]
Popovici, D.C.; Marin, A.M.; Ionescu, O.; Moraru, M.M.F.; Kaya, D.A.; Imre, M.; Mederle, N. First Molecular Data of Gongylonema pulchrum (Rhabditida: Gongylonematidae) in European Fallow Deer Dama dama from Romania. Pathogens,  2024, 13(2), 175.
 [http://dx.doi.org/10.3390/pathogens13020175] [PMID: 38392914]

[5]
Wakelin, D. Pathogenesis and Defenses.In: Medical Microbiology, 4th; Baron, S., Ed.; University of Texas Medical Branch at Galveston: Galveston (TX), 1996, 87, pp. 1-120.

[6]
Anto, E.J.; Nugraha, S.E. Efficacy of albendazole and mebendazole with or without levamisole for ascariasis and trichuriasis. Maced. J. Med. Sci.,  2019, 7(8), 1298.

[7]
Tee, M.Z.; Lee, S.C.; Er, Y.X.; Yap, N.J.; Ngui, R.; Easton, A.V.; Siow, V.W.; Ng, K.S.; Boey, C.C.; Chua, K.H.; Cadwell, K. Efficacy of triple dose albendazole treatment for soil-transmitted helminth infections. PLoS One,  2022, 17(8), 0272821.

[8]
Buonfrate, D.; Rodari, P.; Barda, B.; Page, W.; Einsiedel, L.; Watts, M.R. Current pharmacotherapeutic strategies for Strongyloidiasis and the complications in its treatment. Exp Opin on Pharmaco.,  2022, 3(14), 1617-1628.

[9]
De Silva, N.R.; Sirisena, J.L.; Gunasekera, D.P.; Ismail, M.M.; De Silva, H.J. Effect of mebendazole therapy during pregnancy on birth outcome. Lancet,  1999, 353(9159), 1145-1149.
 [http://dx.doi.org/10.1016/S0140-6736(98)06308-9]

[10]
WHO. 2023. Available from: https://www.who.int/news-room/fact-sheets/detail/soil-transmitted-helminth-infections

[11]
Inam, I.; Sehgal, S. Effect of Mebendazole Therapy during Pregnancy on birth outcome in patients presenting to Ch. Rehmat Ali Memorial Teaching Hospital. P J M H S,  2018, 50(25), 26-30.

[12]
Cezar, A.S.; Toscan, G.; Camillo, G.; Sangioni, L.A.; Ribas, H.O.; Vogel, F.S. Multiple resistance of gastrointestinal nematodes to nine different drugs in a sheep flock in southern Brazil. Vet. Parasitol.,  2010, 173(1-2), 157-160.
 [http://dx.doi.org/10.1016/j.vetpar.2010.06.013]

[13]
Pal, S.K.; Shukla, Y. Herbal medicine: Current status and the future. Asian Pac. J. Cancer Prev.,  2003, 4(4), 281-288.

[14]
Rawat, J.M.; Pandey, S.; Rawat, B.; Rai, N.; Preeti, P.; Thakur, A.; Butola, J.S.; Bachheti, R.K. Traditional uses, active ingredients, and biological activities of Paris polyphylla Smith: A comprehensive review of an important Himalayan medicinal plant. J. Chem.,  2023, 5, 1-8.

[15]
Mwamula, A.O.; Kabir, M.F.; Lee, D. A review of the potency of plant extracts and compounds from key families as an alternative to synthetic nematicides: History, efficacy, and current developments. Plant Pathol. J.,  2022, 38(2), 53-77.
 [http://dx.doi.org/10.5423/PPJ.RW.12.2021.0179] [PMID: 35385913]

[16]
Moro, P.; Schantz, P.M. Echinococcosis: A review. Int. J. Infect. Dis.,  2009, 13(2), 125-133.

[17]
Wen, H.; Vuitton, L.; Tuxun, T.; Li, J.; Vuitton, D.A.; Zhang, W.; McManus, D.P. Echinococcosis: Advances in the 21st Century. Clin. Microbiol. Rev.,  2019, 32(2), e00075-e18.
 [http://dx.doi.org/10.1128/CMR.00075-18] [PMID: 30760475]

[18]
Chitsulo, L.; Engels, D.; Montresor, A.; Savioli, L. The global status of schistosomiasis and its control. Acta Trop.,  2000, 77(1), 41-51.
 [http://dx.doi.org/10.1016/S0001-706X(00)00122-4] [PMID: 10996119]

[19]
Leung, A.K.C.; Leung, A.A.M.; Wong, A.H.C.; Hon, K.L. Human ascariasis: An updated review. Recent Pat. Inflamm. Allergy Drug Discov.,  2020, 14(2), 133-145.
 [http://dx.doi.org/10.2174/22122710MTA3eOTIl5] [PMID: 32628606]

[20]
Crewe, W. Ed.; Blacklock and Southwell’s Guide to Human Parasitology, 11th ed; Chapman and Hall: London, 1990. 

[21]
Maizels, R.M.; Pearce, E.J.; Artis, D.; Yazdanbakhsh, M.; Wynn, T.A. Regulation of pathogenesis and immunity in helminth infections. J. Exp. Med.,  2009, 206(10), 2059-2066.
 [http://dx.doi.org/10.1084/jem.20091903] [PMID: 19770272]

[22]
Despommier, D.D.; Gwadz, R.W.; Hotez, P.J. Parasitic Diseases, 3rd ed; Springer-Verlag: New York, 1995. 
 [http://dx.doi.org/10.1007/978-1-4612-2476-1]

[23]
Jourdan, P.M.; Lamberton, P.H.; Fenwick, A.; Addiss, D.G. Soil-transmitted helminth infections. Lancet,  2018, 391(10117), 252-265.
 [http://dx.doi.org/10.1016/S0140-6736(17)31930-X]

[24]
Idris, O.A.; Wintola, O.A.; Afolayan, A.J. Helminthiases; prevalence, transmission, host-parasite interactions, resistance to common synthetic drugs and treatment. Heliyon,  2019, 5(1), e01161.

[25]
Agarwal, R.; Kharya, M.D.; Shrivastava, R. Antimicrobial & anthelmintic activities of the essential oil of Nigella sativa Linn. Indian J. Exp. Biol.,  1979, 17(11), 1264-1265.
 [PMID: 549848]

[26]
Štrbac, F.; Krnjajić, S.; Maurelli, M.P.; Stojanović, D.; Simin, N.; Orčić, D.; Ratajac, R.; Petrović, K.; Knežević, G.; Cringoli, G.; Rinaldi, L. A potential anthelmintic phytopharmacological source of Origanum vulgare (L.) essential oil against gastrointestinal nematodes of sheep. Ani.,  2022, 13(1), 45.

[27]
Sarwa, K.; Vishwakarma, P.; Suryawanshi, V.; Sahu, T.; Kumar, L.; Shree, J. An Ayurvedic formulation Sankat Mochan: A potent anthelmintic medicine. Drug. Develop. Therap.,  2017, 8(1), 13-16.
 [http://dx.doi.org/10.4103/ddt.DDT_84_15]

[28]
Jamkhande, P.G.; Barde, S.R. Evaluation of anthelmintic activity and in silico PASS assisted prediction of Cordia dichotoma (Forst.) root extract. Anc. Sci. Life,  2014, 34(1), 39-34.

[29]
Chaturvedi, M.; Dwivedi, S.; Dwivedi, A.; Barpete, P.K.; Sachan, R. Formulation and evaluation of polyherbal anthelmintic preparation. Ethnobot Leaflets.,  2009, 2009(2), 7-27.

[30]
Singh, K.; Agrawal, K.K.; Gupta, J.K. Comparative anthelmintic activity of Aegle marmelos Linn leaves and pulp. J. Pharm.,  2012, 2, 395-397.

[31]
Kumar, D.; Tandan, S.K.; Singh, T.U. Paralytic effect of alcoholic extract of Allium sativum and Piper longum on liver amphistome, Gigantocotyle explanatum. Indian J. Pharmacol.,  2008, 40(2), 64-68.
 [http://dx.doi.org/10.4103/0253-7613.41040] [PMID: 21279168]

[32]
Singh, Anthelmintic activity of Vernonia anthelmintica. Indian Drugs.,  1985, 22, 508-511.

[33]
Sathya, V.; Shanmugapriya, C.; Gandhimathi, S.; Shameem, F.R. In-vitro anthelmintic activity of Achyranthes aspera Linn. (Whole Plant) against pheretima posthuma. J Res Sid Med.,  2014, 1(1), 68-71.

[34]
Basha, S.N.; Rekha, R.; Saleh, S.; Yemane, S. Evaluation of In vitro anthelmintic activities of Brassica nigra, Ocimum basilicum and Rumex abyssinicus. Pharm. J.,  2011, 3(20), 88-92.

[35]
Venkatesh, Anthelmintic Activity of Musa paradisiaca (L.) cv. Puttabale. Int. J. Pharm. Sci. Drug Res.,  2013, 5(2), 67-69.

[36]
Tousif, M.I.; Nazir, M.; Saleem, M.; Tauseef, S.; Shafiq, N.; Hassan, L.; Hussian, H.; Montesano, D.; Naviglio, D.; Zengin, G.; Ahmad, I. An incalculable but underexplored food crop: Its phytochemistry, ethnopharmacology, and industrial applications. Mole.,  2022, 27(20), 7016.

[37]
Khan, S.; Meena, A.K.; Saluja, A. In-vitro anthelmintic evaluation of polyherbal formulation. Krumighattini Tablet. Res.J. Pharmacol. Pharmacodyn.,  2015, 7(4), 181-183.
 [http://dx.doi.org/10.5958/2321-5836.2015.00036.1]

[38]
Chen, R.P.; Soren, A.D.; Yadav, A.K. Anthelmintic evaluation of three ayurvedic formulations: A transmission electron microscopy study in Raillietina sp. (Cestoda). J. Parasit. Dis.,  2023, 47(4), 837-842.
 [http://dx.doi.org/10.1007/s12639-023-01630-6] [PMID: 38009143]

[39]
Ramaiah, M.; Chakravathi, G.; Yasaswini, K. In vitro biological standardization, formulation and evaluation of directly compressed polyherbal anthelmintic tablets. Pharmacogn. J.,  2013, 5(3), 130-134.
 [http://dx.doi.org/10.1016/j.phcgj.2013.04.004]

[40]
Ibrahim, A.M. Anthelmintic activity of some sudanese medicinal plants. Phytother. Res.,  1992, 6(3), 155-157.
 [http://dx.doi.org/10.1002/ptr.2650060312]

[41]
Bachaya, H.A.; Iqbal, Z.; Khan, M.N.; Sindhu, Z.D.; Jabbar, A. Anthelmintic activity of Ziziphus nummularia (bark) and Acacia nilotica (fruit) against Trichostrongylid nematodes of sheep. J. Ethnopharmacol.,  2009, 123(2), 325-329.
 [http://dx.doi.org/10.1016/j.jep.2009.02.043] [PMID: 19429379]

[42]
Husori, D.I. In-vitro Anthelmintic Activity of Acanthus ilicifolius Leaves Extracts on Ascaridia galli and Pheretima posthuma. J. Appl. Pharm. Sci.,  2018, 8(02), 164-167.

[43]
Gunalan, G.; Esther, J.; Sangeetha, N.; Balabhaskar, R. In vitro anthelmintic activity of Achyranthes aspera Linn. (Whole Plant) Against Pheretima posthuma. Journal of Research in Siddha Medicine,  2018, 1(1), 68-71.
 [http://dx.doi.org/10.4103/2582-1954.328148]

[44]
Raj, R.K. Screening of some indigenous plants for anthelmintic action against human Ascaris lumbricoides. Indian J. Physiol. Pharmacol.,  1974, 18(2), 129-131.
 [PMID: 4415695]

[45]
Sharma, G.P.; Jain, N.K.; Garg, B.D. Anthelmintic activity of some essential oils; Indian Perfumer, 1979, pp. 210-212.

[46]
Nanda, A.; Iyengar, M.A.; Narayan, C.S.; Kalkarni, D.R. Investigations on the root bark of Aglaia odoratissima. Fitoterapia,  1987, 58, 189-191.

[47]
Dubey, M.P.; Gupta, I. Studies on the anthelmintic activity of Alangium lamarikii Thwaites (Hindi Akol) root bark. Indian J. Physiol. Pharmacol.,  1968, 12, 25-31.
 [PMID: 5673667]

[48]
Pandey, R.S. Anthelmintic activity of Alangium salviifolium bark. J Nat Prod Plant Resour.,  2012, 2(6), 717-720.

[49]
Panda, S.K.; Padhi, L.; Leyssen, P.; Liu, M.; Neyts, J.; Luyten, W. Antimicrobial, anthelmintic, and antiviral activity of plants traditionally used for treating infectious disease in the similipal biosphere reserve. Front. Pharmacol.,  2017, 8, 658.
 [http://dx.doi.org/10.3389/fphar.2017.00658] [PMID: 29109684]

[50]
Kaushik, R.K.; Katiyar, J.C.; Sen, A.B. A new in-vitro screening technique for anthelmintic activity using Ascaridia galli as a test parasite. Indian J. Anim. Sci.,  1981, 51, 869-872.

[51]
Garg, S.C.; Kasera, H.L. Anthelmintic activity of Callistemon viminalis. Fitoterapia LIII.,  1982, 53, 179-181.

[52]
Garg, S.C.; Kasera, H.L. In vitro anthelmintic activity of the essential of Anacardium occidentale. Indian Perfumer.,  1982, 26, 239-240.

[53]
Sujon, M.A.; Mostofa, M.; Jahan, M.S.; Das, A.R.; Rob, S. Studies on medicinal plants against gastroinstestinal nematodes of goats. Bangladesh J. Vet. Med.,  1970, 6(2), 179-183.
 [http://dx.doi.org/10.3329/bjvm.v6i2.2333]

[54]
Neogi, N.C.; Baliga, P.A.C.; Srivastava, R.K. Anthelmintic activity of some indigenous drugs. Indian J. Pharm.,  1964, 26, 37.

[55]
Nazneen, F.; Muddassir, M.; Meshram, K.; Umekar, M.J.; Lohiya, R.T. Phytochemical screening and comparative anthelmintic activity of alchoholic extracts of some herbal plants. J Pharm Sci & Res.,  2017, 9, 1240-1242.

[56]
Grover, J.K.; Vats, V.; Uppal, G.; Yadav, S. Anthelmintics: A review. Trop. Gastroenterol.,  2001, 22(4), 180-189.
 [PMID: 11963321]

[57]
Siddiqui, N.; Garg, S.C. In-vitro anthelmintic activity of some essential oils. Pak. J. Sci. Ind. Res.,  1990, 33, 536-537.

[58]
Naqvi, S.A.H.; Vohora, S.B.; Khan, M.S.Y. Antibacteria, antifungal and anthelmintic studies of Artemisia scoparia. Herba Hungarica.,  1991, 30, 54-60.

[59]
Tariq, K.A.; Chishti, M.Z.; Ahmad, F.; Shawl, A.S. Anthelmintic activity of extracts of Artemisia absinthium against ovine nematodes. Vet. Parasitol.,  2009, 160(1-2), 83-88.
 [http://dx.doi.org/10.1016/j.vetpar.2008.10.084] [PMID: 19070963]

[60]
Iqbal, Z.; Lateef, M.; Ashraf, M.; Jabbar, A. Anthelmintic activity of Artemisia brevifolia in sheep. J. Ethnopharmacol.,  2004, 93(2-3), 265-268.
 [http://dx.doi.org/10.1016/j.jep.2004.03.046] [PMID: 15234763]

[61]
Nakhare, S.; Garg, S.C. Anthelmintic activity of the essential oil of artemisia pallens wall. Anc. Sci. Life,  1991, 10(3), 185-186.
 [PMID: 22556530]

[62]
Irum, S.; Ahmed, H.; Mirza, B.; Donskow-Łysoniewska, K.; Muhammad, A.; Qayyum, M.; Simsek, S. In vitro and in vivo anthelmintic activity of extracts from Artemisia parviflora and A. sieversiana. Helminthologia,  2017, 54(3), 218-224.
 [http://dx.doi.org/10.1515/helm-2017-0028]

[63]
Rabiu, H.; Subhasish, M. Investigation of in-vitro anthelmintic activity of Azadirachta Indica Leaves. Int J Drug Dev & Res.,  2011, 3(4), 94-100.

[64]
Gaind, K.N.; Budhiraja, R.D. Antibacterial and anthelmintic activity of Withania coagulans Dunal. Indian J. Pharm.,  1967, 29, 185-186.

[65]
Gaind, K.N.; Mital, H.C.; Khanna, S.R. Anthelmintic activity of Triphala. Indian J. Pharm.,  1964, 26, 106-107.

[66]
Sambodo, P.; Prastowo, J.; Kurniasih, K.; Indarjulianto, S. In vitro potential anthelmintic activity of Biophytum petersianum on Haemonchus contortus. Vet. World,  2018, 11(1), 1-4.
 [http://dx.doi.org/10.14202/vetworld.2018.1-4] [PMID: 29479148]

[67]
Shelu, S.; Jangde, C.; Nanotkar, R.; Limsay, R.; Awasthy, V.; Singh, R. Evaluation of anthelmintic activity (In vitro) of Boerhaavia diffusa Linn (Punarnava) root extract including phytochemical screening. Int. J. Livest. Res.,  2017, 7(5), 1.
 [http://dx.doi.org/10.5455/ijlr.20170330053039]

[68]
Girgune, J.B.; Jain, N.K.; Garg, B.D. Anthelmintic activity of some essential oils. Indian Perfumer.,  1978, 22, 296-297.

[69]
Girgune, J.B.; Jain, N.K.; Garg, B.D. Antimicrobial and anthelmintic activity of essential oil from Gardenia lucida Roxb. Indian Perfumer,  1979, XXIII(3-4), 213-215.

[70]
Wang, Y.; Wu, Z.F.; Wang, G.X.; Wang, F.; Liu, Y.T.; Li, F.Y.; Han, J. In vivo anthelmintic activity of bruceine A and bruceine D from Brucea javanica against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus). Vet. Parasitol.,  2011, 177(1-2), 127-133.
 [http://dx.doi.org/10.1016/j.vetpar.2010.11.040] [PMID: 21196080]

[71]
Dengre, S.L. Chemical and physiological examination of essential oils from Indian sources; Dr. Hari Singh Gour Vishwavidyalaya; Sagar: India, 1982, pp. 171-179.

[72]
Lal, J.; Chandra, S.; Sabir, M. Modified method for isolation of Palasonin Ð the anthelmintic principle of Butea frondosa seeds. Indian J. Pharm. Sci.,  1978, 97-98.

[73]
Prashanth, D.; Asha, M.K.; Amit, A.; Padmaja, R. Anthelmintic activity of Butea monosperma. Fitoterapia,  2001, 72(4), 421-422.
 [http://dx.doi.org/10.1016/S0367-326X(00)00333-6] [PMID: 11395269]

[74]
Akhtar, M.S.; Riffat, S. A field trial of Paganum harmala Linn. seeds (Harmal) against natural cestodal infection in Betel goats. J Pharm Univ Kar Pak.,  1986, 4, 79-84.

[75]
Akhtar, M.S.; Riffat, S. Evaluation of anticestodal activity of Lagenaria siceraria (Kaddoo) seeds in sheep. Pak. Vet. J.,  1987, 7, 139-141.

[76]
Akhtar, M.S.; Riffat, S. Evaluation of Melia azedarach Linn. seeds (Bakain) and piperazine against Ascaridia galli infection in chickens. Pak. Vet. J.,  1985, 5, 34-37.

[77]
Jabbar, A.; Zaman, M.A.; Iqbal, Z.; Yaseen, M.; Shamim, A. Anthelmintic activity of Chenopodium album (L.) and Caesalpinia crista (L.) against trichostrongylid nematodes of sheep. J. Ethnopharmacol.,  2007, 114(1), 86-91.
 [http://dx.doi.org/10.1016/j.jep.2007.07.027] [PMID: 17826017]

[78]
Das, K.; Dang, R.; Sivaraman, G.; Ellath, R.P. Phytochemical screening for various secondary metabolites, antioxidant, and anthelmintic activity of Coscinium fenestratum Fruit Pulp: A new biosource for novel drug discovery. Turk. J. Pharm. Sci.,  2018, 15(2), 156-165.
 [http://dx.doi.org/10.4274/tjps.54376] [PMID: 32454655]

[79]
Das, R.; Mehta, D.K.; Gupta, A. In vitro anthelmintic activity of leaves of juglans regia l against pheretima posthuma. Sci Revs Chem Commun.,  2011, 1(1), 78-82.

[80]
Das, S. In vitro anthelmintic activity of leaf extracts of four different types of calamus species. Pharm. Pharmacol. Int. J.,  2017, 5(2), 72-76.

[81]
Mukadam, M. In vitro anthelmintic activity of various plant extracts against Pheretima posthuma. Int. J. Adv. Res. Sci. Eng. Technol.,  2016, 3, 3068-3071.

[82]
Dwivedi, G.; Rawal, D.; Nagda, S.; Jain, T. Anthelmintic activity of Tea (Camellia sinensis) extract. Int. J. Pharm. Sci. Res.,  2010, 1, 451-453.

[83]
Satrija, F.; Nansen, P.; Murtini, S.; He, S. Anthelmintic activity of papaya latex against patent Heligmosomoides polygyrus infections in mice. J. Ethnopharmacol.,  1995, 48(3), 161-164.
 [http://dx.doi.org/10.1016/0378-8741(95)01298-R] [PMID: 8719976]

[84]
Kawade Tripti, J.; Vite Manisha, H. Phytochemical Investigation and In vitro Evaluation of Anthelmintic Activity of Cassia tora Linn. Int J Pharm Clin Res.,  2013, 5(1), 32-36.

[85]
Deore, S.L.; Khadabadi, S.S. In vitro anthelmintic study of Chlorophytum borivilianum Sant. &. Fernandez. Indian J. Nat. Prod. Resour.,  2010, 1, 53-56.

[86]
Mahatma, N.; Murugesan, S.; Ponnudurai, G. Screening for anthelmintic activity of cleome viscosa plant extract In vitro. Int. J. Sci. Environ. Technol.,  2017, 6, 1569-1573.

[87]
Modi, A.J.; Khadabadi, S.S.; Deore, S.L. In vitro anthelmintic activity of Clerodendrum Infortunatum. Int. J. Pharm. Tech. Res.,  2010, 2(1), 375-377.

[88]
Swargiary, A.; Daimari, A.; Daimari, M.; Basumatary, N.; Narzary, E. Phytochemicals, antioxidant, and anthelmintic activity of selected traditional wild edible plants of lower Assam. Indian J. Pharmacol.,  2016, 48(4), 418-423.
 [http://dx.doi.org/10.4103/0253-7613.186212] [PMID: 27756954]

[89]
Shekhawat, N.; Vijayvergia, R. Anthelmintic Activity of extracts of some medicinal Plants. Int J Comp Sci & Mathe.,  2011, 3, 183-187.

[90]
Dhar, R.N.; Garg, L.C.; Pathak, R.D. Anthelmintic activity of Carica papya seeds. Indian J. Pharm.,  1965, 27, 335-336.

[91]
Kakrani, H.K.; Kalyani, G.A. Anthelmintic activity of the essential oil of Commiphora mukul. Fitoterapia,  1984, 55, 232-234.

[92]
Grzybek, M.; Kukula-Koch, W.; Strachecka, A.; Jaworska, A.; Phiri, A.; Paleolog, J.; Tomczuk, K. Evaluation of anthelmintic activity and composition of Pumpkin (Cucurbita pepo L.) Seed Extracts— In vitro and in vivo Studies. Int. J. Mol. Sci.,  2016, 17(9), 1456.
 [http://dx.doi.org/10.3390/ijms17091456] [PMID: 27598135]

[93]
Srivastava, M.C.; Singh, S.W. Anthelmintic activity of Cucurbita maxima (kaddu) seeds. Indian J. Med. Res.,  1967, 55(6), 629-632.
 [PMID: 6076370]

[94]
Shrivastava, R. Anthelmintic properties of essential oil of Cyathocline lyrata Cass. Indian J. Pharm. Sci.,  1979, 41, 228-229.

[95]
Madhavan, M.; Tharakan, S.T. Evaluation of phytochemicals, total phenols, antioxidant and anthelmintic activity of hot water extracts of Cuminum cyminum seeds. Int. Res. J. Pharm.,  2017, 8(11), 135-139.
 [http://dx.doi.org/10.7897/2230-8407.0811232]

[96]
Kokate, C.K.; Varma, K.C. Anthelmintic activity of some essential oils. Indian J. Hosp. Pharm.,  1971, 8, 150-151.

[97]
Joshi, U.M.; Wagh, R.D. In-Vitro anthelmintic activity of ehretia laevis bark on indian adult earthworm. Int. J. Pharmac. Res. Schol.,  2018, 7(4), 22-30.

[98]
Patel, J.; Kumar, G.S.; Qureshi, M.S.; Jena, P.K. Anthelmintic activity of Ethanolic extract of whole plant of Eupatorium odoratum. L. Int. J. Phytomed.,  2010, 2(2), 127-132.
 [http://dx.doi.org/10.5138/ijpm.2010.0975.0185.02020]

[99]
Kalpana1 T, Nandini NK, Priyanka RS, Sravya U, Likitha Y and Mounica P. Phytochemical screening and anthelmintic activity of aerial parts of aqueous methanolic extract of euphorbiahirta against earth worms. Int. J. Innov. Res. Sci. Eng. Technol.,  2018, 7, 1323-1325.

[100]
Dixit, V.K.; Varma, K.C. Anthelmintic properties of essential oils from rhizomes of Hedychium coronarium Koenig and Hedychium spicatum Koenig. Indian J. Pharm.,  1975, 37, 143-144.

[101]
Amini, M.H. Assessment of In-Vitro anthelmintic activity of Heracleum afghanicum Kitamura leaves. Int J Green Pharm.,  2017, 11(4), 244-247.

[102]
Boggula, N.; Vanamala, N.; Bakshi, V. Phytochemical screening and anthelmintic activity of root extract of Hugonia Mystax Linn against pheretima posthuma: An In-vitro study. Int Conference Series on Multidisciplinary Sci.,  2018, 4, 1-13.

[103]
Nayak, B.S.; Jena, P.K.; Sahu, N.P. Comparative study of anthelmintic activity between aqueous and ethanolic extract of Solanum Surattense linn. Int. J. Pharm. Pharm. Sci.,  2009, 1, 10-27.

[104]
Nayak, P.S.; Nayak, S.; Kar, D.M.; Das, P. In-vitro anthelmintic activity of whole plant extracts of Hyptis Suaveolens poit. Int. J. Curr. Pharm. Res.,  2010, 2, 50-51.

[105]
Mishra, S.H.; Gaud, R.S.; Sharma, R.A.; Chaturvedi, S.C. Anthelmintic activity of some essential oils. Indian Perfumer.,  1979, 3(4), 208-209.

[106]
Srikanth, I.; Kiran Kumar, V. In vitro anthelmintic activity of Ipomea Aquatica. Int. J. Curr. Pharm. Res.,  2016, 10, 52-54.

[107]
Agrahari, A.K.; Meher, A.; Padhan, A.R.; Dash, S. Assessment of anthelmintic activity of Jussiaea hyssopifolia G. Don. Asian J Plant Sci Res,  2011, 1(4), 87-91.

[108]
Saha, M.R.; Debnath, P.C.; Rahman, M.A.; Islam, M.A.U. Evaluation of In vitro anthelmintic activities of leaf and stem extracts of Justicia gendarussa. Bangladesh J. Pharmacol.,  2012, 7(1), 50-53.
 [http://dx.doi.org/10.3329/bjp.v7i1.10558]

[109]
Avadhoot, Y.; Dixit, V.K.; Varma, K.C. Anthelmintic activity of essential oil of seeds of Lantana camara var. aculeata L. Indian Drugs Pharm. Indust.,  1980, 15, 19-20.

[110]
Gnaneswari, K.; Padma, Y.; Raju, R.R.V.; Jayaveera, K.N. In vitro anthelmintic activity of Leonotis nepetiifolia (L.) R.Br., a potential medicinal plant. J. Chem. Pharm. Res.,  2013, 5(2), 345-348.

[111]
Reddy, G.B.S.; Melkhani, A.B.; Kalyani, G.A.; Rao, J.V.; Shirwaikar, A.; Kotian, M.; Ramani, R.; Aithal, K.S.; Udupa, A.L.; Bhat, G.; Srinivasan, K.K. Chemical and pharmacological investigations of Limnophila conferta and L. heterophylla. Int. J. Pharmacogn.,  1991, 29(2), 145-153.
 [http://dx.doi.org/10.3109/13880209109082868]

[112]
Partap, S.; Kumar, S.; Kumar, A.; Sharma, N.K.; Jha, K.K. In vitro anthelmintic activity of Luffa cylindrica leaves in indian adult earthworm. J. Pharmacogn. Phytochem.,  2012, 1, 27-30.

[113]
Rahman, M.; Hasanat, A.; Ali, S.; Kabir, M.S.H.; Alam, M.; Hossain, M.M.; Habib, M.Z.; Chowdhury, T.A. In vitro anthelmintic activity of methanolic extract of Macaranga denticulata leaves in Pheretima posthuma. J. Phytopharmacol.,  2015, 4(2), 113-115.
 [http://dx.doi.org/10.31254/phyto.2015.4210]

[114]
Chandran, R. P.; v, D.; Krishna, S.; Fathima, S.; Thaha, A.; Raj, J. Analysis of phytochemical constituents and anthelmintic activity of leaf extracts of Mimosa pudica L. Asian. J. Biomed. Pharmac. Sci.,  2018, 8(65), 1-5.
 [http://dx.doi.org/10.4066/2249-622X.65.18-614]

[115]
Riffat, S.; Akhtar, M.S.; Javed, I.; Shah, B.H. Antinematodal and anticestodal efficacy of Morus alba Linn. stem-bark in sheep. Pak. J. Agric. Sci.,  1986, 23, 122-129.

[116]
Sujith, S. S.; Priya MN, P.; Deepa CK, D.; Usha PTA, U. Characterization of the anthelmintic activity of Murraya koenigii (Linn.). Pharmacogn. J.,  2018, 10(6s), s100-s103.
 [http://dx.doi.org/10.5530/pj.2018.6s.19]

[117]
Hussain, A.; Khan, M.N.; Iqbal, Z.; Sajid, M.S.; Khan, M.K. Anthelmintic activity of Trianthema portulacastrum L. and Musa paradisiaca L. against gastrointestinal nematodes of sheep. Vet. Parasitol.,  2011, 179(1-3), 92-99.
 [http://dx.doi.org/10.1016/j.vetpar.2011.02.022] [PMID: 21440370]

[118]
Raghavamma, S.T.V.; Rao, N.R. In vitro evaluation of anthelmintic activity of Nauclea orientalis leaves. Indian J. Pharm. Sci.,  2010, 72(4), 520-521.
 [http://dx.doi.org/10.4103/0250-474X.73932] [PMID: 21218070]

[119]
Kalyani, G.A.; Aithal, K.S.; Srivastava, K.K. In vitro anthelmintic activity of essential oil from the fruits of Zanthoxylum limonella. Fitoterapia LX,  1989, 60(2), 160-162.

[120]
Ahmed, A.I. Anthelmintic activity of Nyctanthes Arbortristis Leaves on Indian earth worms. Indian J Drugs.,  2016, 4(2), 63-68.

[121]
Asha, M.K.; Prashanth, D.; Murali, B.; Padmaja, R.; Amit, A. Anthelmintic activity of essential oil of Ocimum sanctum and eugenol. Fitoterapia,  2001, 72(6), 669-670.
 [http://dx.doi.org/10.1016/S0367-326X(01)00270-2] [PMID: 11543966]

[122]
Kumar, S. In vitro anthelmintic activity and phytochemical analysis of for tropical plants against Haemonchus contortus. Int. J. Adv. Res.,  2015, 3(6), 541-548.

[123]
Akter, KN Evaluation of antibacterial and anthelmintic activities with total phenolic contents of Piper betle leaves. J. phytomediicne.,  2014, 4, 30-39.

[124]
Ali, S.M.; Mehta, R.K. Preliminary pharmacological and anthelmintic studies of the essential oil of Piper betle L. Indian J. Pharm.,  1970, 32, 132-133.

[125]
Kumar, H.K.S.; Bose, A.; Raut, A.; Sahu, S.K.; Raju, M.B.V. Evaluation of anthelmintic activity of Pistia stratiotes Linn. J. Basic Clin. Pharm.,  2010, 1(2), 103-105.
 [PMID: 24825974]

[126]
Sutar, N.; Garai, R.; Sharma, U.S.; Sharma, U.K. jaiswal, A. Anthelmintic activity of Platycladus orientalis leaves extract. Int. J. Parasitol. Res.,  2010, 2(2), 1-3.
 [http://dx.doi.org/10.9735/0975-3702.2.2.1-3]

[127]
Srivastava, A.; Gupta, A.K.; Rajendiran, A. Phytochemical screening and in-vitro anthelmintic activity of methanolic extract from the stem bark of Plumeria rubra linn. Int. J. Pharm. Sci. Res.,  2017, 8(12), 5336-1.

[128]
Durgawale, T.P.; Khanwelkar, C.C.; Durgawale, P.P.; Kakade, S.V. Comparative anthelmintic activity of different extracts of Portulaca Oleraceae L. whole plant. Biomed. Pharmacol. J.,  2017, 10(4), 2-4.
 [http://dx.doi.org/10.13005/bpj/1322]

[129]
Lone, B.A.; Mz, C.; Fa, B.H.T.; Sa, B.A.K. Anthelmintic activities of aqueous and methanol extracts of Prunella vulgaris L. Nat. Prod. Chem. Res.,  2017, 5(4), 269.
 [http://dx.doi.org/10.4172/2329-6836.1000269]

[130]
Javed, I.; Akhtar, M.S. Efficacy and safety of Psoralea corylifolia Linn. seeds and its extracts in methanol and water against mixed gastrointestinal nematode infection in sheep. J Pharm Pb Univ Lhr Pak.,  1986, 7, 9-13.

[131]
Prakash, V.; Singhal, K.C.; Gupta, R.R. Anthelmintic activity of Punica granatum and Artemisia silversiana. Indian J. Pharmacol.,  1980, 12, 62.

[132]
Chattopadhyaya, M.K.; Khare, R.L. Isolation of anacardic acid from Semecarpus anacardium L. and study of its anthelmintic activity. Indian J. Pharm.,  1969, 31, 104-105.

[133]
Gulnaz, A.R.; Savitha, G. Evaluation of anthelmintic activity of different leaf and stem extract of Sida cordata burm. F. Int. J. Curr. Microbiol. Appl. Sci.,  2013, 2(11), 247-255.

[134]
Yadav, A.K.; Tangpu, V. Anthelmintic activity of ripe fruit extract of Solanum myriacanthum Dunal (Solanaceae) against experimentally induced Hymenolepis diminuta (Cestoda) infections in rats. Parasitol. Res.,  2012, 110(2), 1047-1053.
 [http://dx.doi.org/10.1007/s00436-011-2596-9] [PMID: 21842379]

[135]
Hemamalini, K.; Rajani, A.; Vasireddy, U. sundari, E.R. Anthelmintic activity of methanolic leaf extract of Sophora interrupta. Int. Res. J. Pharm.,  2013, 4(8), 148-150.
 [http://dx.doi.org/10.7897/2230-8407.04828]

[136]
Hajra, S.; Mehta, A.; Pandey, P. In vitro anthelmintic activity of Swietenia Mahagoni seed extracts against Pheritima posthuma. Int. J. Pharm. Sci. Rev. Res.,  2012, 12, 111-113.

[137]
Devi, B.N.; Swarnalatha, D.; Gopinath, C.; Adinarayana, K. Anthelmintic activity of Tephrosia calophylla. J. Pharm. Res.,  2017, 11(1), 35-38.

[138]
Anuracpreeda, P.; Chawengkirttikul, R.; Ngamniyom, A.; Panyarachun, B.; Puttarak, P.; Koedrith, P.; Intaratat, N. The in vitro anthelmintic activity of the ethanol leaf extracts of Terminalia catappa L. on Fasciola gigantica. Parasitology,  2017, 144(14), 1931-1942.
 [http://dx.doi.org/10.1017/S0031182017001445] [PMID: 28805167]

[139]
Kosalge, S.B.; Fursule, R.A. Investigation of in vitro anthelmintic activity of Thespesia lampas (cav.). Asian J. Pharm. Clin. Res.,  2009, 2, 69-71.

[140]
Mehta, M.B.; Kharya, M.D.; Srivastava, R.; Varma, K.C. Antimicrobial and anthelmintic activities of the essential oil of Zanthoxylum alatum Roxb. Indian Perfumer.,  1981, 25, 1-3.

[141]
Ganguly, S.; Barkataki, S.; Sanga, P.; Boopathi, K.; Kanagasabai, K.; Devika, S.; Karmakar, S.; Chowdhury, P.; Sarkar, R.; Raj, D.; James, L.; Dutta, S.; Campbell, S.J.; Murhekar, M. Epidemiology of soil-transmitted helminth Infections among primary school children in the states of Chhattisgarh, Telangana, and Tripura, India, 2015-2016. Am. J. Trop. Med. Hyg.,  2022, 107(1), 122-129.
 [http://dx.doi.org/10.4269/ajtmh.21-1185] [PMID: 35576946]

[142]
Jamwal, S.; Kumar, P.; Kakkar, V.; Kumari, P.; Chahal, S.K. Protocols in apoptosis identification and affirmation. Clinical Perspectives and Targeted Therapies in Apoptosis.,  2021, 1, 127-152.
 [http://dx.doi.org/10.1016/B978-0-12-815762-6.00005-6]

[143]
Drudge, J.H.; Leland, S.J.; Wyant, Z.N. Strain variation in the response of sheep nematodes to the action of phenothiazine. I. Studies of mixed infections in experimental animals. Am. J. Vet. Res.,  1957, 18(66), 133-141.
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DOI https://dx.doi.org/10.2174/0122113525304411240528074154	Print ISSN 2211-3525
Publisher Name Bentham Science Publisher	Online ISSN 2211-3533
Anti-Infective Agents

A Review of Traditional Anthelmintic Approaches: Exploring Medicinal Plants and Polyherbal Formulations for Effective and Safe Gastrointestinal Parasite Treatment

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