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Research Article

Sustainable Green Synthesis and Molecular Docking Study of a Bis-Fused System Incorporating Pyrido[2,3-d]pyrimidine using Nanocatalyst under Microwave Condition

Author(s): Elshimaa M. Eid*

Volume 4, 2024

Published on: 15 June, 2024

Article ID: e200624231074 Pages: 12

DOI: 10.2174/0126660016263316240610065901

Price: $65

Abstract

Aims: This study aimed to employ sustainable green methods in the synthesis of bisfused cycles incorporating pyrido[2,3-d]pyrimidine moiety using a green catalyst nano ZnO catalyst by one-pot, multicomponent reaction among 2,2'-(propane-1,3-diylbis(sulfanediyl)) bis(6-aminopyrimidin-4(3H)-one) 3, 1H-indene-1,3(2H)-dione 4, and aromatic aldehydes 5.

Method: The reactions proceeded with both conventional and microwave (MW) irradiation methods.

Result: The microwave-assisted method carried out the reaction in 10 min and had high yields (89-95%).

Conclusion: A molecular docking simulation study was conducted using human serum albumin (PDB: ID (2XVQ)). The study revealed that compounds strongly fit into the active sites of the target protein.

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