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Review Article

Role of Polyphenols to Attenuate Depressive Disorders and Cognitive Impairments Associated with Diabetes Mellitus – A Comprehensive Review

In Press, (this is not the final "Version of Record"). Available online 06 June, 2024
Author(s): Sejuti Ray Chowdhury, Sourav Ghosh*, Monosiz Rahaman and Srabona Dutta
Published on: 06 June, 2024

Article ID: e060624230792

DOI: 10.2174/0122103155295956240529155913

Price: $95

Abstract

Diabetes Mellitus and its associated brain disorders become more prevalent across the globe. Several comorbidity factors are associated with diabetic mellitus as well as the nervous system. Static molecular variations in the Central Nervous System (CNS) due to Hyperglycemia may be a major cause of psychiatric disorders. Carbohydrates and proteins imbalance as metabolic parameters impact the downregulation of neurotransmitters in the brain region. Glucose metabolism has a key role in brain physiology as well as in neuro-energetics, transmission, and defensive mechanisms of the brain. Several studies revealed that CNS-acting medications overstated the glucose homeostasis associated with brain functioning as well as pharmacological effects. Polyphenols are an assembly of plant-derived composites with anti-inflammatory properties working on the inflammatory markers as well as antioxidant possessions that decrease the oxidative stress that is accompanied by a low pervasiveness of metabolic conditions categorized by insulin resistance. Those Natural products influenced the molecular signaling pathway, which is directly related to depression, cognitive impairment and neurotransmission. Currently, there are not any exact pharmacotherapies accessible for CNS form-induced diabetes. However, around some prebiotics, probiotics with natural remedies show promise in treating these central nervous system difficulties. Consequently, proof-based research concluded the translational study with a clinical setting understanding the connotation among brain glucose homeostasis and central nervous system complications is warranted, and the progress of pharmacologically dynamic therapy for active treatment of comorbidities diseases related to diabetes mellitus.

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