Beyond the Genome: Deciphering the Role of MALAT1 in Breast Cancer Progression

Sung, H.; Ferlay, J.; Siegel, R.L.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin., 2021, 71(3), 209-249.
[http://dx.doi.org/10.3322/caac.21660] [PMID: 33538338]

Tiwary, S.; Hussain, M.S. Functional foods for prevention and treatment of cancer. Asian J. Pharm. Clin. Res., 2021, 14(3), 4-10.
[http://dx.doi.org/10.22159/ajpcr.2021.v14i3.40426]

Hussain, M.S.; Altamimi, A.S.A.; Afzal, M.; Almalki, W.H.; Kazmi, I.; Alzarea, S.I.; Gupta, G.; Shahwan, M.; Kukreti, N.; Wong, L.S.; Kumarasamy, V.; Subramaniyan, V. Kaempferol: Paving the path for advanced treatments in aging-related diseases. Exp. Gerontol., 2024, 188, 112389.
[http://dx.doi.org/10.1016/j.exger.2024.112389] [PMID: 38432575]

Lee, A; Mavaddat, N; Wilcox, AN; Cunningham, AP; Carver, T; Hartley, S BOADICEA: A comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors. Genetics in Medicine, 2019, 21, 1708-1718.

Grimaldi, A.M.; Incoronato, M. Clinical Translatability of “Identified” Circulating miRNAs for Diagnosing Breast Cancer: Overview and Update. Cancers, 2019, 11(7), 901.
[http://dx.doi.org/10.3390/cancers11070901] [PMID: 31252695]

Hussain, M.S.; Gupta, G.; Afzal, M.; Alqahtani, S.M.; Samuel, V.P.; Almalki, H.W.; Kazmi, I.; Alzarea, S.I.; Saleem, S.; Dureja, H.; Singh, S.K.; Dua, K.; Thangavelu, L. Exploring the role of lncrna neat1 knockdown in regulating apoptosis across multiple cancer types: A review. Pathol. Res. Pract., 2023, 252, 154908.
[http://dx.doi.org/10.1016/j.prp.2023.154908] [PMID: 37950931]

Li, K.; Tian, Y.; Yuan, Y.; Fan, X.; Yang, M.; He, Z.; Yang, D. Insights into the Functions of LncRNAs in Drosophila. Int. J. Mol. Sci., 2019, 20(18), 4646.
[http://dx.doi.org/10.3390/ijms20184646] [PMID: 31546813]

Hussain, M.S.; Majami, A.A.; Ali, H.; Gupta, G.; Almalki, W.H.; Alzarea, S.I.; Kazmi, I.; Syed, R.U.; Khalifa, N.E.; Break, B.M.K.; Khan, R.; Altwaijry, N.; Sharma, R. The complex role of MEG3: An emerging long non-coding RNA in breast cancer. Pathol. Res. Pract., 2023, 251, 154850.
[http://dx.doi.org/10.1016/j.prp.2023.154850] [PMID: 37839358]

Wang, Y.; Liu, Z.; Xu, Z.; Shao, W.; Hu, D.; Zhong, H.; Zhang, J. Introduction of long non-coding RNAs to regulate autophagy-associated therapy resistance in cancer. Mol. Biol. Rep., 2022, 49(11), 10761-10773.
[http://dx.doi.org/10.1007/s11033-022-07669-7] [PMID: 35810239]

Hussain, M.S.; Afzal, O.; Gupta, G.; Altamimi, A.S.A.; Almalki, W.H.; Alzarea, S.I.; Kazmi, I.; Fuloria, N.K.; Sekar, M.; Meenakshi, D.U.; Thangavelu, L.; Sharma, A. Long non-coding RNAs in lung cancer: Unraveling the molecular modulators of MAPK signaling. Pathol. Res. Pract., 2023, 249, 154738.
[http://dx.doi.org/10.1016/j.prp.2023.154738] [PMID: 37595448]

Zhou, Z.; Qi, D.; Gan, Q.; Wang, F.; Qin, B.; Li, J.; Wang, H.; Wang, D. Studies on the Regulatory Roles and Related Mechanisms of lncRNAs in the Nervous System. Oxid. Med. Cell. Longev., 2021, 2021, 1-12.
[http://dx.doi.org/10.1155/2021/6657944] [PMID: 33791072]

Cao, H.; Li, D.; Lu, H.; Sun, J.; Li, H. Uncovering potential lncRNAs and nearby mRNAs in systemic lupus erythematosus from the Gene Expression Omnibus dataset. Epigenomics, 2019, 11(16), 1795-1809.
[http://dx.doi.org/10.2217/epi-2019-0145] [PMID: 31755746]

Bian, B.; Li, L.; Ke, X.; Chen, H.; Liu, Y.; Zheng, N.; Zheng, Y.; Ma, Y.; Zhou, Y.; Yang, J.; Xiao, L.; Shen, L. Urinary exosomal long non-coding RNAs as noninvasive biomarkers for diagnosis of bladder cancer by RNA sequencing. Front. Oncol., 2022, 12, 976329.
[http://dx.doi.org/10.3389/fonc.2022.976329] [PMID: 36119544]

Zhou, Q.; Yu, Q.; Gong, Y.; Liu, Z.; Xu, H.; Wang, Y.; Shi, Y. Construction of a lncRNA-miRNA-mRNA network to determine the regulatory roles of lncRNAs in psoriasis. Exp. Ther. Med., 2019, 18(5), 4011-4021.
[http://dx.doi.org/10.3892/etm.2019.8035] [PMID: 31611939]

Hussain, M.S.; Afzal, O.; Gupta, G.; Altamimi, A.S.A.; Almalki, W.H.; Alzarea, S.I.; Kazmi, I.; Kukreti, N.; Gupta, S.; Sulakhiya, K.; Singh, S.K.; Dua, K. Probing the links: Long non-coding RNAs and NF-κB signalling in atherosclerosis. Pathol. Res. Pract., 2023, 249, 154773.
[http://dx.doi.org/10.1016/j.prp.2023.154773] [PMID: 37647827]

Hussain, M.S.; Afzal, O.; Gupta, G.; Goyal, A.; Almalki, W.H.; Kazmi, I.; Alzarea, S.I.; Altamimi, A.A.S.; Kukreti, N.; Chakraborty, A.; Singh, S.K.; Dua, K. Unraveling NEAT1's complex role in lung cancer biology: A comprehensive review. EXCLI J., 2024, 23, 34-52.
[PMID: 38343745]

Zhou, Q.; Liu, L.; Zhou, J.; Chen, Y.; Xie, D.; Yao, Y.; Cui, D. Novel Insights Into MALAT1 Function as a MicroRNA Sponge in NSCLC. Front. Oncol., 2021, 11, 758653.
[http://dx.doi.org/10.3389/fonc.2021.758653] [PMID: 34778078]

Syllaios, A.; Moris, D.; Karachaliou, G.; Sakellariou, S.; Karavokyros, I.; Gazouli, M.; Schizas, D. Pathways and role of MALAT1 in esophageal and gastric cancer (Review). Oncol. Lett., 2021, 21(5), 343.
[http://dx.doi.org/10.3892/ol.2021.12604] [PMID: 33747200]

Su, K; Wang, N; Shao, Q; Liu, H; Zhao, B; Ma, S The role of a ceRNA regulatory network based on lncRNA MALAT1 site in cancer progression. Biomed Pharmacother, 2021, 137, 111389.
[http://dx.doi.org/10.1016/j.biopha.2021.111389]

Ma, Z.; Zhang, J.; Xu, X.; Qu, Y.; Dong, H.; Dang, J.; Huo, Z.; Xu, G. LncRNA expression profile during autophagy and Malat1 function in macrophages. PLoS One, 2019, 14(8), e0221104.
[http://dx.doi.org/10.1371/journal.pone.0221104] [PMID: 31425535]

Hussain, M.S.; Shaikh, N.K.; Agrawal, M.; Tufail, M.; Bisht, A.S.; Khurana, N.; Kumar, R. Osteomyelitis and non-coding RNAS: A new dimension in disease understanding. Pathol. Res. Pract., 2024, 255, 155186.
[http://dx.doi.org/10.1016/j.prp.2024.155186] [PMID: 38350169]

Farooqi, A.A.; Legaki, E.; Gazouli, M.; Rinaldi, S.; Berardi, R. MALAT1 as a Versatile Regulator of Cancer: Overview of the updates from Predatory role as Competitive Endogenous RNA to Mechanistic Insights. Curr. Cancer Drug Targets, 2020.
[PMID: 32748748]

Li, Z.; Hou, P.; Fan, D.; Dong, M.; Ma, M.; Li, H.; Yao, R.; Li, Y.; Wang, G.; Geng, P.; Mihretab, A.; Liu, D.; Zhang, Y.; Huang, B.; Lu, J. The degradation of EZH2 mediated by lncRNA ANCR attenuated the invasion and metastasis of breast cancer. Cell Death Differ., 2017, 24(1), 59-71.
[http://dx.doi.org/10.1038/cdd.2016.95] [PMID: 27716745]

Yang, F.; Shen, Y.; Zhang, W.; Jin, J.; Huang, D.; Fang, H.; Ji, W.; Shi, Y.; Tang, L.; Chen, W.; Zhou, G.; Guan, X. An androgen receptor negatively induced long non-coding RNA ARNILA binding to miR-204 promotes the invasion and metastasis of triple-negative breast cancer. Cell Death Differ., 2018, 25(12), 2209-2220.
[http://dx.doi.org/10.1038/s41418-018-0123-6] [PMID: 29844570]

Li, R.H.; Chen, M.; Liu, J.; Shao, C.C.; Guo, C.P.; Wei, X.L.; Li, Y.C.; Huang, W.H.; Zhang, G.J. Long noncoding RNA ATB promotes the epithelial−mesenchymal transition by upregulating the miR-200c/Twist1 axe and predicts poor prognosis in breast cancer. Cell Death Dis., 2018, 9(12), 1171.
[http://dx.doi.org/10.1038/s41419-018-1210-9] [PMID: 30518916]

Song, R.; Zhang, J.; Huang, J.; Hai, T. Long non-coding RNA GHET1 promotes human breast cancer cell proliferation, invasion and migration via affecting epithelial mesenchymal transition. Cancer Biomark., 2018, 22(3), 565-573.
[http://dx.doi.org/10.3233/CBM-181250] [PMID: 29843220]

Wang, Z.; Yang, B.; Zhang, M.; Guo, W.; Wu, Z.; Wang, Y.; Jia, L.; Li, S.; Xie, W.; Yang, D.; Johnson, C.S.J.; Demchok, J.A.; Felau, I.; Kasapi, M.; Ferguson, M.L.; Hutter, C.M.; Sofia, H.J.; Tarnuzzer, R.; Wang, Z.; Yang, L.; Zenklusen, J.C.; Zhang, J.J.; Chudamani, S.; Liu, J.; Lolla, L.; Naresh, R.; Pihl, T.; Sun, Q.; Wan, Y.; Wu, Y.; Cho, J.; DeFreitas, T.; Frazer, S.; Gehlenborg, N.; Getz, G.; Heiman, D.I.; Kim, J.; Lawrence, M.S.; Lin, P.; Meier, S.; Noble, M.S.; Saksena, G.; Voet, D.; Zhang, H.; Bernard, B.; Chambwe, N.; Dhankani, V.; Knijnenburg, T.; Kramer, R.; Leinonen, K.; Liu, Y.; Miller, M.; Reynolds, S.; Shmulevich, I.; Thorsson, V.; Zhang, W.; Akbani, R.; Broom, B.M.; Hegde, A.M.; Ju, Z.; Kanchi, R.S.; Korkut, A.; Li, J.; Liang, H.; Ling, S.; Liu, W.; Lu, Y.; Mills, G.B.; Ng, K-S.; Rao, A.; Ryan, M.; Wang, J.; Weinstein, J.N.; Zhang, J.; Abeshouse, A.; Armenia, J.; Chakravarty, D.; Chatila, W.K.; Bruijn, I.; Gao, J.; Gross, B.E.; Heins, Z.J.; Kundra, R.; La, K.; Ladanyi, M.; Luna, A.; Nissan, M.G.; Ochoa, A.; Phillips, S.M.; Reznik, E.; Vega, S.F.; Sander, C.; Schultz, N.; Sheridan, R.; Sumer, S.O.; Sun, Y.; Taylor, B.S.; Wang, J.; Zhang, H.; Anur, P.; Peto, M.; Spellman, P.; Benz, C.; Stuart, J.M.; Wong, C.K.; Yau, C.; Hayes, D.N.; Parker, J.S.; Wilkerson, M.D.; Ally, A.; Balasundaram, M.; Bowlby, R.; Brooks, D.; Carlsen, R.; Chuah, E.; Dhalla, N.; Holt, R.; Jones, S.J.M.; Kasaian, K.; Lee, D.; Ma, Y.; Marra, M.A.; Mayo, M.; Moore, R.A.; Mungall, A.J.; Mungall, K.; Robertson, A.G.; Sadeghi, S.; Schein, J.E.; Sipahimalani, P.; Tam, A.; Thiessen, N.; Tse, K.; Wong, T.; Berger, A.C.; Beroukhim, R.; Cherniack, A.D.; Cibulskis, C.; Gabriel, S.B.; Gao, G.F.; Ha, G.; Meyerson, M.; Schumacher, S.E.; Shih, J.; Kucherlapati, M.H.; Kucherlapati, R.S.; Baylin, S.; Cope, L.; Danilova, L.; Bootwalla, M.S.; Lai, P.H.; Maglinte, D.T.; Van Den Berg, D.J.; Weisenberger, D.J.; Auman, J.T.; Balu, S.; Bodenheimer, T.; Fan, C.; Hoadley, K.A.; Hoyle, A.P.; Jefferys, S.R.; Jones, C.D.; Meng, S.; Mieczkowski, P.A.; Mose, L.E.; Perou, A.H.; Perou, C.M.; Roach, J.; Shi, Y.; Simons, J.V.; Skelly, T.; Soloway, M.G.; Tan, D.; Veluvolu, U.; Fan, H.; Hinoue, T.; Laird, P.W.; Shen, H.; Zhou, W.; Bellair, M.; Chang, K.; Covington, K.; Creighton, C.J.; Dinh, H.; Doddapaneni, H.V.; Donehower, L.A.; Drummond, J.; Gibbs, R.A.; Glenn, R.; Hale, W.; Han, Y.; Hu, J.; Korchina, V.; Lee, S.; Lewis, L.; Li, W.; Liu, X.; Morgan, M.; Morton, D.; Muzny, D.; Santibanez, J.; Sheth, M.; Shinbrot, E.; Wang, L.; Wang, M.; Wheeler, D.A.; Xi, L.; Zhao, F.; Hess, J.; Appelbaum, E.L.; Bailey, M.; Cordes, M.G.; Ding, L.; Fronick, C.C.; Fulton, L.A.; Fulton, R.S.; Kandoth, C.; Mardis, E.R.; McLellan, M.D.; Miller, C.A.; Schmidt, H.K.; Wilson, R.K.; Crain, D.; Curley, E.; Gardner, J.; Lau, K.; Mallery, D.; Morris, S.; Paulauskis, J.; Penny, R.; Shelton, C.; Shelton, T.; Sherman, M.; Thompson, E.; Yena, P.; Bowen, J.; Foster, G.J.M.; Gerken, M.; Leraas, K.M.; Lichtenberg, T.M.; Ramirez, N.C.; Wise, L.; Zmuda, E.; Corcoran, N.; Costello, T.; Hovens, C.; Carvalho, A.L.; de Carvalho, A.C.; Fregnani, J.H.; Filho, L.A.; Reis, R.M.; Neto, S.C.; Silveira, H.C.S.; Vidal, D.O.; Burnette, A.; Eschbacher, J.; Hermes, B.; Noss, A.; Singh, R.; Anderson, M.L.; Castro, P.D.; Ittmann, M.; Huntsman, D.; Kohl, B.; Le, X.; Thorp, R.; Andry, C.; Duffy, E.R.; Lyadov, V.; Paklina, O.; Setdikova, G.; Shabunin, A.; Tavobilov, M.; McPherson, C.; Warnick, R.; Berkowitz, R.; Cramer, D.; Feltmate, C.; Horowitz, N.; Kibel, A.; Muto, M.; Raut, C.P.; Malykh, A.; Sloan, B.J.S.; Barrett, W.; Devine, K.; Fulop, J.; Ostrom, Q.T.; Shimmel, K.; Wolinsky, Y.; Sloan, A.E.; De Rose, A.; Giuliante, F.; Goodman, M.; Karlan, B.Y.; Hagedorn, C.H.; Eckman, J.; Harr, J.; Myers, J.; Tucker, K.; Zach, L.A.; Deyarmin, B.; Hu, H.; Kvecher, L.; Larson, C.; Mural, R.J.; Somiari, S.; Vicha, A.; Zelinka, T.; Bennett, J.; Iacocca, M.; Rabeno, B.; Swanson, P.; Latour, M.; Lacombe, L.; Têtu, B.; Bergeron, A.; McGraw, M.; Staugaitis, S.M.; Chabot, J.; Hibshoosh, H.; Sepulveda, A.; Su, T.; Wang, T.; Potapova, O.; Voronina, O.; Desjardins, L.; Mariani, O.; Roman, R.S.; Sastre, X.; Stern, M-H.; Cheng, F.; Signoretti, S.; Berchuck, A.; Bigner, D.; Lipp, E.; Marks, J.; McCall, S.; McLendon, R.; Secord, A.; Sharp, A.; Behera, M.; Brat, D.J.; Chen, A.; Delman, K.; Force, S.; Khuri, F.; Magliocca, K.; Maithel, S.; Olson, J.J.; Owonikoko, T.; Pickens, A.; Ramalingam, S.; Shin, D.M.; Sica, G.; Van Meir, E.G.; Zhang, H.; Eijckenboom, W.; Gillis, A.; Korpershoek, E.; Looijenga, L.; Oosterhuis, W.; Stoop, H.; van Kessel, K.E.; Zwarthoff, E.C.; Calatozzolo, C.; Cuppini, L.; Cuzzubbo, S.; DiMeco, F.; Finocchiaro, G.; Mattei, L.; Perin, A.; Pollo, B.; Chen, C.; Houck, J.; Lohavanichbutr, P.; Hartmann, A.; Stoehr, C.; Stoehr, R.; Taubert, H.; Wach, S.; Wullich, B.; Kycler, W.; Murawa, D.; Wiznerowicz, M.; Chung, K.; Edenfield, W.J.; Martin, J.; Baudin, E.; Bubley, G.; Bueno, R.; De Rienzo, A.; Richards, W.G.; Kalkanis, S.; Mikkelsen, T.; Noushmehr, H.; Scarpace, L.; Girard, N.; Aymerich, M.; Campo, E.; Giné, E.; Guillermo, A.L.; Van Bang, N.; Hanh, P.T.; Phu, B.D.; Tang, Y.; Colman, H.; Evason, K.; Dottino, P.R.; Martignetti, J.A.; Gabra, H.; Juhl, H.; Akeredolu, T.; Stepa, S.; Hoon, D.; Ahn, K.; Kang, K.J.; Beuschlein, F.; Breggia, A.; Birrer, M.; Bell, D.; Borad, M.; Bryce, A.H.; Castle, E.; Chandan, V.; Cheville, J.; Copland, J.A.; Farnell, M.; Flotte, T.; Giama, N.; Ho, T.; Kendrick, M.; Kocher, J-P.; Kopp, K.; Moser, C.; Nagorney, D.; O’Brien, D.; O’Neill, B.P.; Patel, T.; Petersen, G.; Que, F.; Rivera, M.; Roberts, L.; Smallridge, R.; Smyrk, T.; Stanton, M.; Thompson, R.H.; Torbenson, M.; Yang, J.D.; Zhang, L.; Brimo, F.; Ajani, J.A.; Gonzalez, A.M.A.; Behrens, C.; Bondaruk, J.; Broaddus, R.; Czerniak, B.; Esmaeli, B.; Fujimoto, J.; Gershenwald, J.; Guo, C.; Lazar, A.J.; Logothetis, C.; Bernstam, M.F.; Moran, C.; Ramondetta, L.; Rice, D.; Sood, A.; Tamboli, P.; Thompson, T.; Troncoso, P.; Tsao, A.; Wistuba, I.; Carter, C.; Haydu, L.; Hersey, P.; Jakrot, V.; Kakavand, H.; Kefford, R.; Lee, K.; Long, G.; Mann, G.; Quinn, M.; Saw, R.; Scolyer, R.; Shannon, K.; Spillane, A.; Stretch, J.; Synott, M.; Thompson, J.; Wilmott, J.; Al-Ahmadie, H.; Chan, T.A.; Ghossein, R.; Gopalan, A.; Levine, D.A.; Reuter, V.; Singer, S.; Singh, B.; Tien, N.V.; Broudy, T.; Mirsaidi, C.; Nair, P.; Drwiega, P.; Miller, J.; Smith, J.; Zaren, H.; Park, J-W.; Hung, N.P.; Kebebew, E.; Linehan, W.M.; Metwalli, A.R.; Pacak, K.; Pinto, P.A.; Schiffman, M.; Schmidt, L.S.; Vocke, C.D.; Wentzensen, N.; Worrell, R.; Yang, H.; Moncrieff, M.; Goparaju, C.; Melamed, J.; Pass, H.; Botnariuc, N.; Caraman, I.; Cernat, M.; Chemencedji, I.; Clipca, A.; Doruc, S.; Gorincioi, G.; Mura, S.; Pirtac, M.; Stancul, I.; Tcaciuc, D.; Albert, M.; Alexopoulou, I.; Arnaout, A.; Bartlett, J.; Engel, J.; Gilbert, S.; Parfitt, J.; Sekhon, H.; Thomas, G.; Rassl, D.M.; Rintoul, R.C.; Bifulco, C.; Tamakawa, R.; Urba, W.; Hayward, N.; Timmers, H.; Antenucci, A.; Facciolo, F.; Grazi, G.; Marino, M.; Merola, R.; de Krijger, R.; Roqueplo, G.A-P.; Piché, A.; Chevalier, S.; McKercher, G.; Birsoy, K.; Barnett, G.; Brewer, C.; Farver, C.; Naska, T.; Pennell, N.A.; Raymond, D.; Schilero, C.; Smolenski, K.; Williams, F.; Morrison, C.; Borgia, J.A.; Liptay, M.J.; Pool, M.; Seder, C.W.; Junker, K.; Omberg, L.; Dinkin, M.; Manikhas, G.; Alvaro, D.; Bragazzi, M.C.; Cardinale, V.; Carpino, G.; Gaudio, E.; Chesla, D.; Cottingham, S.; Dubina, M.; Moiseenko, F.; Dhanasekaran, R.; Becker, K-F.; Janssen, K-P.; Huspenina, S.J.; Rahman, A.M.H.; Aziz, D.; Bell, S.; Cebulla, C.M.; Davis, A.; Duell, R.; Elder, J.B.; Hilty, J.; Kumar, B.; Lang, J.; Lehman, N.L.; Mandt, R.; Nguyen, P.; Pilarski, R.; Rai, K.; Schoenfield, L.; Senecal, K.; Wakely, P.; Hansen, P.; Lechan, R.; Powers, J.; Tischler, A.; Grizzle, W.E.; Sexton, K.C.; Kastl, A.; Henderson, J.; Porten, S.; Waldmann, J.; Fassnacht, M.; Asa, S.L.; Schadendorf, D.; Couce, M.; Graefen, M.; Huland, H.; Sauter, G.; Schlomm, T.; Simon, R.; Tennstedt, P.; Olabode, O.; Nelson, M.; Bathe, O.; Carroll, P.R.; Chan, J.M.; Disaia, P.; Glenn, P.; Kelley, R.K.; Landen, C.N.; Phillips, J.; Prados, M.; Simko, J.; McCune, S.K.; VandenBerg, S.; Roggin, K.; Fehrenbach, A.; Kendler, A.; Sifri, S.; Steele, R.; Jimeno, A.; Carey, F.; Forgie, I.; Mannelli, M.; Carney, M.; Hernandez, B.; Campos, B.; Mende, H.C.; Jungk, C.; Unterberg, A.; von Deimling, A.; Bossler, A.; Galbraith, J.; Jacobus, L.; Knudson, M.; Knutson, T.; Ma, D.; Milhem, M.; Sigmund, R.; Godwin, A.K.; Madan, R.; Rosenthal, H.G.; Adebamowo, C.; Adebamowo, S.N.; Boussioutas, A.; Beer, D.; Giordano, T.; Mes-Masson, A-M.; Saad, F.; Bocklage, T.; Landrum, L.; Mannel, R.; Moore, K.; Moxley, K.; Postier, R.; Walker, J.; Zuna, R.; Feldman, M.; Valdivieso, F.; Dhir, R.; Luketich, J.; Pinero, E.M.M.; Aguilo, Q.M.; Carlotti, C.G., Jr; Dos Santos, J.S.; Kemp, R.; Sankarankuty, A.; Tirapelli, D.; Catto, J.; Agnew, K.; Swisher, E.; Creaney, J.; Robinson, B.; Shelley, C.S.; Godwin, E.M.; Kendall, S.; Shipman, C.; Bradford, C.; Carey, T.; Haddad, A.; Moyer, J.; Peterson, L.; Prince, M.; Rozek, L.; Wolf, G.; Bowman, R.; Fong, K.M.; Yang, I.; Korst, R.; Rathmell, W.K.; Campbell, F.J.L.; Hooke, J.A.; Kovatich, A.J.; Shriver, C.D.; DiPersio, J.; Drake, B.; Govindan, R.; Heath, S.; Ley, T.; Van Tine, B.; Westervelt, P.; Rubin, M.A.; Lee, J.I.; Aredes, N.D.; Mariamidze, A. lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell- Cycle Progression in Cancer. Cancer Cell, 2018, 33(4), 706-720.e9.
[http://dx.doi.org/10.1016/j.ccell.2018.03.006] [PMID: 29622465]

Bai, Y.; Zhou, X.; Huang, L.; Wan, Y.; Li, X.; Wang, Y. Long noncoding RNA EZR-AS1 promotes tumor growth and metastasis by modulating Wnt/β-catenin pathway in breast cancer. Exp. Ther. Med., 2018, 16(3), 2235-2242.
[http://dx.doi.org/10.3892/etm.2018.6461] [PMID: 30186463]

Zhong, H.; Yang, J.; Zhang, B.; Wang, X.; Pei, L.; Zhang, L.; Lin, Z.; Wang, Y.; Wang, C. LncRNA GACAT3 predicts poor prognosis and promotes cell proliferation in breast cancer through regulation of miR-497/CCND2. Cancer Biomark., 2018, 22(4), 787-797.
[http://dx.doi.org/10.3233/CBM-181354] [PMID: 29945347]

Liu, M.; Gou, L.; Xia, J.; Wan, Q.; Jiang, Y.; Sun, S.; Tang, M.; He, T.; Zhang, Y. LncRNA ITGB2-AS1 Could Promote the Migration and Invasion of Breast Cancer Cells through Up-Regulating ITGB2. Int. J. Mol. Sci., 2018, 19(7), 1866.
[http://dx.doi.org/10.3390/ijms19071866] [PMID: 29941860]

Lu, G.; Li, Y.; Ma, Y.; Lu, J.; Chen, Y.; Jiang, Q. Long noncoding RNA LINC00511 contributes to breast cancer tumourigenesis and stemness by inducing the miR-185-3p/E2F1/Nanog axis. Journal of experimental & clinical cancer research. CR (East Lansing Mich.), 2018, 37(1), 289.

Huang, X.; Xie, X.; Liu, P.; Yang, L.; Chen, B.; Song, C.; Tang, H.; Xie, X. Adam12 and lnc015192 act as ceRNAs in breast cancer by regulating miR-34a. Oncogene, 2018, 37(49), 6316-6326.
[http://dx.doi.org/10.1038/s41388-018-0410-1] [PMID: 30042416]

Yang, Y.; Yang, H.; Xu, M.; Zhang, H.; Sun, M.; Mu, P.; Dong, T.; Du, S.; Liu, K. Long non-coding RNA (lncRNA) MAGI2-AS3 inhibits breast cancer cell growth by targeting the Fas/FasL signalling pathway. Hum. Cell, 2018, 31(3), 232-241.
[http://dx.doi.org/10.1007/s13577-018-0206-1] [PMID: 29679339]

Zhang, W; Shi, S; Jiang, J; Li, X; Lu, H; Ren, F. LncRNA MEG3 inhibits cell epithelial-mesenchymal transition by sponging miR-421 targeting E-cadherin in breast cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, 91, 312-9.

Wang, S.; Ke, H.; Zhang, H.; Ma, Y.; Ao, L.; Zou, L.; Yang, Q.; Zhu, H.; Nie, J.; Wu, C.; Jiao, B. LncRNA MIR100HG promotes cell proliferation in triple-negative breast cancer through triplex formation with p27 loci. Cell Death Dis., 2018, 9(8), 805.
[http://dx.doi.org/10.1038/s41419-018-0869-2] [PMID: 30042378]

Li, W.; Zhang, Z.; Liu, X.; Cheng, X.; Zhang, Y.; Han, X.; Zhang, Y.; Liu, S.; Yang, J.; Xu, B.; He, L.; Sun, L.; Liang, J.; Shang, Y. The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer. J. Clin. Invest., 2017, 127(9), 3421-3440.
[http://dx.doi.org/10.1172/JCI94233] [PMID: 28805661]

Wu, W.; Chen, F.; Cui, X.; Yang, L.; Chen, J.; Zhao, J.; Huang, D.; Liu, J.; Yang, L.; Zeng, J.; Zeng, Z.; Pan, Y.; Su, F.; Cai, J.; Ying, Z.; Zhao, Q.; Song, E.; Su, S. LncRNA NKILA suppresses TGF-β-induced epithelial–mesenchymal transition by blocking NF-κB signaling in breast cancer. Int. J. Cancer, 2018, 143(9), 2213-2224.
[http://dx.doi.org/10.1002/ijc.31605] [PMID: 29761481]

Li, Y; Lv, M; Song, Z; Lou, Z; Wang, R; Zhuang, M. Long non-coding RNA NNT-AS1 affects progression of breast cancer through miR-142-3p/ZEB1 axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie., 2018, 103, 939-46.

Yang, Y.X.; Wei, L.; Zhang, Y.J.; Hayano, T.; Pereda, P.M.P.; Nakaoka, H.; Li, Q.; Mallofret, B.I.; Lu, Y.Z.; Tamagnone, L.; Inoue, I.; Li, X.; Luo, J.Y.; Zheng, K.; You, H. Long non-coding RNA p10247, high expressed in breast cancer (lncRNA-BCHE), is correlated with metastasis. Clin. Exp. Metastasis, 2018, 35(3), 109-121.
[http://dx.doi.org/10.1007/s10585-018-9901-2] [PMID: 29948648]

Jadaliha, M.; Gholamalamdari, O.; Tang, W.; Zhang, Y.; Petracovici, A.; Hao, Q.; Tariq, A.; Kim, T.G.; Holton, S.E.; Singh, D.K.; Li, X.L.; Freier, S.M.; Ambs, S.; Bhargava, R.; Lal, A.; Prasanth, S.G.; Ma, J.; Prasanth, K.V. A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability. PLoS Genet., 2018, 14(11), e1007802.
[http://dx.doi.org/10.1371/journal.pgen.1007802] [PMID: 30496290]

Liang, Y.; Song, X.; Li, Y.; Sang, Y.; Zhang, N.; Zhang, H.; Liu, Y.; Duan, Y.; Chen, B.; Guo, R.; Zhao, W.; Wang, L.; Yang, Q. A novel long non-coding RNA-PRLB acts as a tumor promoter through regulating miR-4766-5p/SIRT1 axis in breast cancer. Cell Death Dis., 2018, 9(5), 563.
[http://dx.doi.org/10.1038/s41419-018-0582-1] [PMID: 29752439]

Shi, X.; Tang, X.; Su, L. Overexpression of Long Noncoding RNA PTENP1 Inhibits Cell Proliferation and Migration via Suppression of miR-19b in Breast Cancer Cells. Oncol. Res., 2018, 26(6), 869-878.
[http://dx.doi.org/10.3727/096504017X15123838050075] [PMID: 29212574]

Tang, J.; Li, Y.; Sang, Y.; Yu, B.; Lv, D.; Zhang, W.; Feng, H. LncRNA PVT1 regulates triple-negative breast cancer through KLF5/beta-catenin signaling. Oncogene, 2018, 37(34), 4723-4734.
[http://dx.doi.org/10.1038/s41388-018-0310-4] [PMID: 29760406]

Li, T.; Liu, Y.; Xiao, H.; Xu, G. Long non-coding RNA TUG1 promotes cell proliferation and metastasis in human breast cancer. Breast Cancer, 2017, 24(4), 535-543.
[http://dx.doi.org/10.1007/s12282-016-0736-x] [PMID: 27848085]

Li, G.Y.; Wang, W.; Sun, J.Y.; Xin, B.; Zhang, X.; Wang, T.; Zhang, Q.F.; Yao, L.B.; Han, H.; Fan, D.M.; Yang, A.G.; Jia, L.T.; Wang, L. Long non-coding RNAs AC026904.1 and UCA1: A “one-two punch” for TGF-β-induced SNAI2 activation and epithelial-mesenchymal transition in breast cancer. Theranostics, 2018, 8(10), 2846-2861.
[http://dx.doi.org/10.7150/thno.23463] [PMID: 29774079]

Marx, S.J. Molecular genetics of multiple endocrine neoplasia types 1 and 2. Nat. Rev. Cancer, 2005, 5(5), 367-375.
[http://dx.doi.org/10.1038/nrc1610] [PMID: 15864278]

Marsh, D.J.; Gimm, O. Multiple endocrine neoplasia: Types 1 and 2. Adv. Otorhinolaryngol., 2011, 70, 84-90.
[http://dx.doi.org/10.1159/000322479] [PMID: 21358189]

Ji, P.; Diederichs, S.; Wang, W.; Böing, S.; Metzger, R.; Schneider, P.M.; Tidow, N.; Brandt, B.; Buerger, H.; Bulk, E.; Thomas, M.; Berdel, W.E.; Serve, H.; Tidow, M.C. MALAT-1, a novel noncoding RNA, and thymosin β4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene, 2003, 22(39), 8031-8041.
[http://dx.doi.org/10.1038/sj.onc.1206928] [PMID: 12970751]

Hutchinson, J.N.; Ensminger, A.W.; Clemson, C.M.; Lynch, C.R.; Lawrence, J.B.; Chess, A. A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains. BMC Genomics, 2007, 8(1), 39.
[http://dx.doi.org/10.1186/1471-2164-8-39] [PMID: 17270048]

Faber, G.P.; Eliyahu, N.S.; Tal, S.Y. Nuclear speckles – A driving force in gene expression. J. Cell Sci., 2022, 135(13), jcs259594.
[http://dx.doi.org/10.1242/jcs.259594] [PMID: 35788677]

Ulitsky, I.; Shkumatava, A.; Jan, C.H.; Sive, H.; Bartel, D.P. Conserved function of lincRNAs in vertebrate embryonic development despite rapid sequence evolution. Cell, 2011, 147(7), 1537-1550.
[http://dx.doi.org/10.1016/j.cell.2011.11.055] [PMID: 22196729]

Wilusz, J.E.; JnBaptiste, C.K.; Lu, L.Y.; Kuhn, C.D.; Tor, J.L.; Sharp, P.A. A triple helix stabilizes the 3′ ends of long noncoding RNAs that lack poly(A) tails. Genes Dev., 2012, 26(21), 2392-2407.
[http://dx.doi.org/10.1101/gad.204438.112] [PMID: 23073843]

Brown, J.A.; Valenstein, M.L.; Yario, T.A.; Tycowski, K.T.; Steitz, J.A. Formation of triple-helical structures by the 3′-end sequences of MALAT1 and MENβ noncoding RNAs. Proc. Natl. Acad. Sci., 2012, 109(47), 19202-19207.
[http://dx.doi.org/10.1073/pnas.1217338109] [PMID: 23129630]

Brown, J.A.; Bulkley, D.; Wang, J.; Valenstein, M.L.; Yario, T.A.; Steitz, T.A.; Steitz, J.A. Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix. Nat. Struct. Mol. Biol., 2014, 21(7), 633-640.
[http://dx.doi.org/10.1038/nsmb.2844] [PMID: 24952594]

Tani, H.; Mizutani, R.; Salam, K.A.; Tano, K.; Ijiri, K.; Wakamatsu, A.; Isogai, T.; Suzuki, Y.; Akimitsu, N. Genome-wide determination of RNA stability reveals hundreds of short-lived noncoding transcripts in mammals. Genome Res., 2012, 22(5), 947-956.
[http://dx.doi.org/10.1101/gr.130559.111] [PMID: 22369889]

Tani, H.; Nakamura, Y.; Ijiri, K.; Akimitsu, N. Stability of MALAT-1, a nuclear long non-coding RNA in mammalian cells, varies in various cancer cells. Drug Discov. Ther., 2010, 4(4), 235-239.
[PMID: 22491206]

Simon, M.D.; Wang, C.I.; Kharchenko, P.V.; West, J.A.; Chapman, B.A.; Alekseyenko, A.A.; Borowsky, M.L.; Kuroda, M.I.; Kingston, R.E. The genomic binding sites of a noncoding RNA. Proc. Natl. Acad. Sci. USA, 2011, 108(51), 20497-20502.
[http://dx.doi.org/10.1073/pnas.1113536108] [PMID: 22143764]

Geng, X.; Zou, Y.; Li, S.; Qi, R.; Yu, H.; Li, J. MALAT1 Mediates α-Synuclein Expression through miR-23b-3p to Induce Autophagic Impairment and the Inflammatory Response in Microglia to Promote Apoptosis in Dopaminergic Neuronal Cells. Mediators Inflamm., 2023, 2023, 1-17.
[http://dx.doi.org/10.1155/2023/4477492] [PMID: 37064502]

Zhang, Y.; Gao, L.; Ma, S.; Ma, J.; Wang, Y.; Li, S.; Hu, X.; Han, S.; Zhou, M.; Zhou, L.; Ding, Z. MALAT1-KTN1-EGFR regulatory axis promotes the development of cutaneous squamous cell carcinoma. Cell Death Differ., 2019, 26(10), 2061-2073.
[http://dx.doi.org/10.1038/s41418-019-0288-7] [PMID: 30683916]

Stone, J.K.; Kim, J.H.; Vukadin, L.; Richard, A.; Giannini, H.K.; Lim, S.T.S.; Tan, M.; Ahn, E.Y.E. Hypoxia induces cancer cell-specific chromatin interactions and increases MALAT1 expression in breast cancer cells. J. Biol. Chem., 2019, 294(29), 11213-11224.
[http://dx.doi.org/10.1074/jbc.RA118.006889] [PMID: 31167784]

Zhou, J.; Wang, M.; Mao, A.; Zhao, Y.; Wang, L.; Xu, Y.; Jia, H.; Wang, L. Long noncoding RNA MALAT1 sponging miR-26a-5p to modulate Smad1 contributes to colorectal cancer progression by regulating autophagy. Carcinogenesis, 2021, 42(11), 1370-1379.
[http://dx.doi.org/10.1093/carcin/bgab069] [PMID: 34313719]

Bamodu, O.A.; Huang, W.C.; Lee, W.H.; Wu, A.; Wang, L.S.; Hsiao, M.; Yeh, C.T.; Chao, T.Y. Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448. BMC Cancer, 2016, 16(1), 160.
[http://dx.doi.org/10.1186/s12885-016-2108-5] [PMID: 26917489]

Li, X. lncRNA MALAT1 promotes diabetic retinopathy by upregulating PDE6G via miR-378a-3p. Arch. Physiol. Biochem., 2021, 130(2), 119-127.
[PMID: 34674599]

Xie, J.J.; Li, W.H.; Li, X.; Ye, W.; Shao, C.F. LncRNA MALAT1 promotes colorectal cancer development by sponging miR-363-3p to regulate EZH2 expression. J. Biol. Regul. Homeost. Agents, 2019, 33(2), 331-343.
[PMID: 30972996]

Xu, W.W.; Jin, J.; Wu, X.; Ren, Q.L.; Farzaneh, M. MALAT1-related signaling pathways in colorectal cancer. Cancer Cell Int., 2022, 22(1), 126.
[http://dx.doi.org/10.1186/s12935-022-02540-y] [PMID: 35305641]

Jiang, X.; Li, D.; Wang, G.; Liu, J.; Su, X.; Yu, W.; Wang, Y.; Zhai, C.; Liu, Y.; Zhao, Z. Thapsigargin promotes colorectal cancer cell migration through upregulation of lncRNA MALAT1. Oncol. Rep., 2020, 43(4), 1245-1255.
[http://dx.doi.org/10.3892/or.2020.7502] [PMID: 32323831]

Ferri, C.; Di Biase, A.; Bocchetti, M.; Zappavigna, S.; Wagner, S.; Le Vu, P. MiR-423-5p prevents MALAT1-mediated proliferation and metastasis in prostate cancer. J. Experimental Clinical Cancer Res. CR , 2022, 41(1), 20.

Hao, L.; Wu, W.; Xu, Y.; Chen, Y.; Meng, C.; Yun, J.; Wang, X. LncRNA-MALAT1: A Key Participant in the Occurrence and Development of Cancer. Molecules, 2023, 28(5), 2126.
[http://dx.doi.org/10.3390/molecules28052126] [PMID: 36903369]

Hussain, M.S.; Altamimi, A.S.A.; Afzal, M.; almalki, W.H.; Kazmi, I.; Alzarea, S.I.; Saleem, S.; Prasher, P.; Oliver, B.; Singh, S.K.; MacLoughlin, R.; Dua, K.; Gupta, G. From carcinogenesis to therapeutic avenues: lncRNAs and mTOR crosstalk in lung cancer. Pathol. Res. Pract., 2024, 253, 155015.
[http://dx.doi.org/10.1016/j.prp.2023.155015] [PMID: 38103364]

Song, Z.; Wang, X.; Chen, F.; Chen, Q.; Liu, W.; Yang, X.; Zhu, X.; Liu, X.; Wang, P. LncRNA MALAT1 regulates METTL3-mediated PD-L1 expression and immune infiltrates in pancreatic cancer. Front. Oncol., 2022, 12, 1004212.
[http://dx.doi.org/10.3389/fonc.2022.1004212] [PMID: 36212476]

Tee, A.E.; Ling, D.; Nelson, C.; Atmadibrata, B.; Dinger, M.E.; Xu, N.; Mizukami, T.; Liu, P.Y.; Liu, B.; Cheung, B.; Pasquier, E.; Haber, M.; Norris, M.D.; Suzuki, T.; Marshall, G.M.; Liu, T. The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1. Oncotarget, 2014, 5(7), 1793-1804.
[http://dx.doi.org/10.18632/oncotarget.1785] [PMID: 24742640]

Yao, Y.; Fan, Y.; Wu, J.; Wan, H.; Wang, J.; Lam, S.; Lam, W.L.; Girard, L.; Gazdar, A.F.; Wu, Z.; Zhou, Q. Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis. Biochem. Biophys. Res. Commun., 2012, 423(3), 613-619.
[http://dx.doi.org/10.1016/j.bbrc.2012.06.050] [PMID: 22713465]

Zhao, Z.; Chen, C.; Liu, Y.; Wu, C. 17β-Estradiol treatment inhibits breast cell proliferation, migration and invasion by decreasing MALAT-1 RNA level. Biochem. Biophys. Res. Commun., 2014, 445(2), 388-393.
[http://dx.doi.org/10.1016/j.bbrc.2014.02.006] [PMID: 24525122]

Jiang, Y.; Li, Y.; Fang, S.; Jiang, B.; Qin, C.; Xie, P.; Zhou, G.; Li, G. The role of MALAT1 correlates with HPV in cervical cancer. Oncol. Lett., 2014, 7(6), 2135-2141.
[http://dx.doi.org/10.3892/ol.2014.1996] [PMID: 24932303]

Guo, F.; Li, Y.; Liu, Y.; Wang, J.; Li, Y.; Li, G. Inhibition of metastasis-associated lung adenocarcinoma transcript 1 in CaSki human cervical cancer cells suppresses cell proliferation and invasion. Acta Biochim. Biophys. Sin., 2010, 42(3), 224-229.
[http://dx.doi.org/10.1093/abbs/gmq008] [PMID: 20213048]

Kan, J.Y.; Wu, D.C.; Yu, F.J.; Wu, C.Y.; Ho, Y.W.; Chiu, Y.J.; Jian, S.F.; Hung, J.Y.; Wang, J.Y.; Kuo, P.L. Chemokine (C-C Motif) Ligand 5 is Involved in Tumor-Associated Dendritic Cell- Mediated Colon Cancer Progression Through Non-Coding RNA MALAT-1. J. Cell. Physiol., 2015, 230(8), 1883-1894.
[http://dx.doi.org/10.1002/jcp.24918] [PMID: 25546229]

Zheng, H.T.; Shi, D.B.; Wang, Y.W.; Li, X.X.; Xu, Y.; Tripathi, P.; Gu, W.L.; Cai, G.X.; Cai, S.J. High expression of lncRNA MALAT1 suggests a biomarker of poor prognosis in colorectal cancer. Int. J. Clin. Exp. Pathol., 2014, 7(6), 3174-3181.
[PMID: 25031737]

Ji, Q.; Zhang, L.; Liu, X.; Zhou, L.; Wang, W.; Han, Z.; Sui, H.; Tang, Y.; Wang, Y.; Liu, N.; Ren, J.; Hou, F.; Li, Q. Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex. Br. J. Cancer, 2014, 111(4), 736-748.
[http://dx.doi.org/10.1038/bjc.2014.383] [PMID: 25025966]

Ji, Q.; Liu, X.; Fu, X.; Zhang, L.; Sui, H.; Zhou, L.; Sun, J.; Cai, J.; Qin, J.; Ren, J.; Li, Q. Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/β- catenin signal pathway. PLoS One, 2013, 8(11), e78700.
[http://dx.doi.org/10.1371/journal.pone.0078700] [PMID: 24244343]

Zhao, Y.; Yang, Y.; Trovik, J.; Sun, K.; Zhou, L.; Jiang, P.; Lau, T.S.; Hoivik, E.A.; Salvesen, H.B.; Sun, H.; Wang, H. A novel wnt regulatory axis in endometrioid endometrial cancer. Cancer Res., 2014, 74(18), 5103-5117.
[http://dx.doi.org/10.1158/0008-5472.CAN-14-0427] [PMID: 25085246]

Kuo, I.Y.; Wu, C.C.; Chang, J.M.; Huang, Y.L.; Lin, C.H.; Yan, J.J.; Sheu, B.S.; Lu, P.J.; Chang, W.L.; Lai, W.W.; Wang, Y.C. Low SOX17 expression is a prognostic factor and drives transcriptional dysregulation and esophageal cancer progression. Int. J. Cancer, 2014, 135(3), 563-573.
[http://dx.doi.org/10.1002/ijc.28695] [PMID: 24407731]

Wang, X.; Li, M.; Wang, Z.; Han, S.; Tang, X.; Ge, Y.; Zhou, L.; Zhou, C.; Yuan, Q.; Yang, M. Silencing of long noncoding RNA MALAT1 by miR-101 and miR-217 inhibits proliferation, migration, and invasion of esophageal squamous cell carcinoma cells. J. Biol. Chem., 2015, 290(7), 3925-3935.
[http://dx.doi.org/10.1074/jbc.M114.596866] [PMID: 25538231]

Koshimizu, T.; Fujiwara, Y.; Sakai, N.; Shibata, K.; Tsuchiya, H. Oxytocin stimulates expression of a noncoding RNA tumor marker in a human neuroblastoma cell line. Life Sci., 2010, 86(11-12), 455-460.
[http://dx.doi.org/10.1016/j.lfs.2010.02.001] [PMID: 20149803]

Fang, D.; Yang, H.; Lin, J.; Teng, Y.; Jiang, Y.; Chen, J.; Li, Y. 17β-Estradiol regulates cell proliferation, colony formation, migration, invasion and promotes apoptosis by upregulating miR-9 and thus degrades MALAT-1 in osteosarcoma cell MG-63 in an estrogen receptor-independent manner. Biochem. Biophys. Res. Commun., 2015, 457(4), 500-506.
[http://dx.doi.org/10.1016/j.bbrc.2014.12.114] [PMID: 25592968]

Taniguchi, M.; Fujiwara, K.; Nakai, Y.; Ozaki, T.; Koshikawa, N.; Toshio, K.; Kataba, M.; Oguni, A.; Matsuda, H.; Yoshida, Y.; Tokuhashi, Y.; Fukuda, N.; Ueno, T.; Soma, M.; Nagase, H. Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole–imidazole polyamide, which targets an E-box motif. FEBS Open Bio, 2014, 4(1), 328-334.
[http://dx.doi.org/10.1016/j.fob.2014.03.004] [PMID: 24918046]

Ren, S.; Liu, Y.; Xu, W.; Sun, Y.; Lu, J.; Wang, F.; Wei, M.; Shen, J.; Hou, J.; Gao, X.; Xu, C.; Huang, J.; Zhao, Y.; Sun, Y. Long noncoding RNA MALAT-1 is a new potential therapeutic target for castration resistant prostate cancer. J. Urol., 2013, 190(6), 2278-2287.
[http://dx.doi.org/10.1016/j.juro.2013.07.001] [PMID: 23845456]

Sowalsky, A.G.; Xia, Z.; Wang, L.; Zhao, H.; Chen, S.; Bubley, G.J.; Balk, S.P.; Li, W. Whole transcriptome sequencing reveals extensive unspliced mRNA in metastatic castration-resistant prostate cancer. Mol. Cancer Res., 2015, 13(1), 98-106.
[http://dx.doi.org/10.1158/1541-7786.MCR-14-0273] [PMID: 25189356]

Hirata, H.; Hinoda, Y.; Shahryari, V.; Deng, G.; Nakajima, K.; Tabatabai, Z.L.; Ishii, N.; Dahiya, R. Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205. Cancer Res., 2015, 75(7), 1322-1331.
[http://dx.doi.org/10.1158/0008-5472.CAN-14-2931] [PMID: 25600645]

Latorre, E.; Carelli, S.; Raimondi, I.; D’Agostino, V.; Castiglioni, I.; Zucal, C.; Moro, G.; Luciani, A.; Ghilardi, G.; Monti, E.; Inga, A.; Di Giulio, A.M.; Gorio, A.; Provenzani, A. The Ribonucleic Complex HuR-MALAT1 Represses CD133 Expression and Suppresses Epithelial–Mesenchymal Transition in Breast Cancer. Cancer Res., 2016, 76(9), 2626-2636.
[http://dx.doi.org/10.1158/0008-5472.CAN-15-2018] [PMID: 27197265]

Tufail, M. The MALAT1-breast cancer interplay: Insights and implications. Expert Rev. Mol. Diagn., 2023, 23(8), 665-678.
[http://dx.doi.org/10.1080/14737159.2023.2233902] [PMID: 37405385]

Yue, X.; Wu, W.; Dong, M.; Guo, M. LncRNA MALAT1 promotes breast cancer progression and doxorubicin resistance via regulating miR-570–3p. Biomed. J., 2021, 44(6), S296-S304.
[http://dx.doi.org/10.1016/j.bj.2020.11.002] [PMID: 35410813]

Chou, J.; Wang, B.; Zheng, T.; Li, X.; Zheng, L.; Hu, J.; Zhang, Y.; Xing, Y.; Xi, T. MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42. Biochem. Biophys. Res. Commun., 2016, 472(1), 262-269.
[http://dx.doi.org/10.1016/j.bbrc.2016.02.102] [PMID: 26926567]

Kim, J.; Piao, H.L.; Kim, B.J.; Yao, F.; Han, Z.; Wang, Y.; Xiao, Z.; Siverly, A.N.; Lawhon, S.E.; Ton, B.N.; Lee, H.; Zhou, Z.; Gan, B.; Nakagawa, S.; Ellis, M.J.; Liang, H.; Hung, M.C.; You, M.J.; Sun, Y.; Ma, L. Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nat. Genet., 2018, 50(12), 1705-1715.
[http://dx.doi.org/10.1038/s41588-018-0252-3] [PMID: 30349115]

Shao, J.; Zhang, Q.; Wang, P.; Wang, Z. LncRNA MALAT1 promotes breast cancer progression by sponging miR101-3p to mediate mTOR/PKM2 signal transmission. Am. J. Transl. Res., 2021, 13(9), 10262-10275.
[PMID: 34650695]

Dolatabadi, F.N.; Dehghani, A.; Shahand, E.; Yazdanshenas, M.; Tabatabaeian, H.; Zamani, A.; Azadeh, M.; Ghaedi, K. The interaction between MALAT1 target, miR-143-3p, and RALGAPA2 is affected by functional SNP rs3827693 in breast cancer. Hum. Cell, 2020, 33(4), 1229-1239.
[http://dx.doi.org/10.1007/s13577-020-00422-x] [PMID: 32880825]

Klopotowska, D.; Matuszyk, J. Downregulation of MALAT1 in triple-negative breast cancer cells. Biochem. Biophys. Rep., 2024, 37, 101592.
[http://dx.doi.org/10.1016/j.bbrep.2023.101592] [PMID: 38088951]

Yu, J.; Jin, T.; Zhang, T. Suppression of Long Non-Coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Potentiates Cell Apoptosis and Drug Sensitivity to Taxanes and Adriamycin in Breast Cancer. Med. Sci. Monit., 2020, 26, e922672.
[http://dx.doi.org/10.12659/MSM.922672] [PMID: 32623440]

Tsyganov, M.M.; Ibragimova, M.K. MALAT1 Long Non-coding RNA and Its Role in Breast Carcinogenesis. Acta Nat., 2023, 15(2), 32-41.
[PMID: 37538803]

Jadaliha, M.; Zong, X.; Malakar, P.; Ray, T.; Singh, D.K.; Freier, S.M.; Jensen, T.; Prasanth, S.G.; Karni, R.; Ray, P.S.; Prasanth, K.V. Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer. Oncotarget, 2016, 7(26), 40418-40436.
[http://dx.doi.org/10.18632/oncotarget.9622] [PMID: 27250026]

Zheng, L.; Zhang, Y.; Fu, Y.; Gong, H.; Guo, J.; Wu, K.; Jia, Q.; Ding, X. Long non-coding RNA MALAT1 regulates BLCAP mRNA expression through binding to miR-339-5p and promotes poor prognosis in breast cancer. Biosci. Rep., 2019, 39(2), BSR20181284.
[http://dx.doi.org/10.1042/BSR20181284] [PMID: 30683807]

Goyal, B.; Yadav, S.R.M.; Awasthee, N.; Gupta, S.; Kunnumakkara, A.B.; Gupta, S.C. Diagnostic, prognostic, and therapeutic significance of long non-coding RNA MALAT1 in cancer. Biochim. Biophys. Acta Rev. Cancer, 2021, 1875(2), 188502.
[http://dx.doi.org/10.1016/j.bbcan.2021.188502] [PMID: 33428963]

Li, J.; Cui, Z.; Li, H.; Lv, X.; Gao, M.; Yang, Z.; Bi, Y.; Zhang, Z.; Wang, S.; Zhou, B.; Yin, Z. Clinicopathological and prognostic significance of long noncoding RNA MALAT1 in human cancers: A review and meta-analysis. Cancer Cell Int., 2018, 18(1), 109.
[http://dx.doi.org/10.1186/s12935-018-0606-z] [PMID: 30093838]

Lin, Q.; Guan, W.; Ren, W.; Zhang, L.; Zhang, J.; Xu, G. MALAT1 affects ovarian cancer cell behavior and patient survival. Oncol. Rep., 2018, 39(6), 2644-2652.
[http://dx.doi.org/10.3892/or.2018.6384] [PMID: 29693187]

Huo, Y.; Li, Q.; Wang, X.; Jiao, X.; Zheng, J.; Li, Z.; Pan, X. MALAT1 predicts poor survival in osteosarcoma patients and promotes cell metastasis through associating with EZH2. Oncotarget, 2017, 8(29), 46993-47006.
[http://dx.doi.org/10.18632/oncotarget.16551] [PMID: 28388584]

Zhao, H.; Wang, Y.; Hou, W.; Ding, X.; Wang, W. Long non-coding RNA MALAT1 promotes cell proliferation, migration and invasion by targeting miR-590-3p in osteosarcoma. Exp. Ther. Med., 2022, 24(5), 672.
[http://dx.doi.org/10.3892/etm.2022.11608] [PMID: 36277152]

Miao, Y.; Fan, R.; Chen, L.; Qian, H. Clinical Significance of Long Non-coding RNA MALAT1 Expression in Tissue and Serum of Breast Cancer. Ann. Clin. Lab. Sci., 2016, 46(4), 418-424.
[PMID: 27466303]

Baloutaki, A.S.; Doosti, A.; Jaafarinia; Goudarzi, H. Editing of the MALAT1 Gene in MDA-MB-361 Breast Cancer Cell Line using the Novel CRISPR Method. Journal of ilam university of medical sciences, 2022, 30(2), 18-31.
[http://dx.doi.org/10.52547/sjimu.30.2.18]

Huang, Y.; Zhou, Z.; Zhang, J.; Hao, Z.; He, Y.; Wu, Z.; Song, Y.; Yuan, K.; Zheng, S.; Zhao, Q.; Li, T.; Wang, B. lncRNA MALAT1 participates in metformin inhibiting the proliferation of breast cancer cell. J. Cell. Mol. Med., 2021, 25(15), 7135-7145.
[http://dx.doi.org/10.1111/jcmm.16742] [PMID: 34164906]

Xie, H.; Liao, X.; Chen, Z.; Fang, Y.; He, A.; Zhong, Y.; Gao, Q.; Xiao, H.; Li, J.; Huang, W.; Liu, Y. LncRNA MALAT1 Inhibits Apoptosis and Promotes Invasion by Antagonizing miR-125b in Bladder Cancer Cells. J. Cancer, 2017, 8(18), 3803-3811.
[http://dx.doi.org/10.7150/jca.21228] [PMID: 29151968]

Sun, Z.; Ou, C.; Liu, J.; Chen, C.; Zhou, Q.; Yang, S.; Li, G.; Wang, G.; Song, J.; Li, Z.; Zhang, Z.; Yuan, W.; Li, X. RETRACTED ARTICLE: YAP1-induced MALAT1 promotes epithelial–mesenchymal transition and angiogenesis by sponging miR-126-5p in colorectal cancer. Oncogene, 2019, 38(14), 2627-2644.
[http://dx.doi.org/10.1038/s41388-018-0628-y] [PMID: 30531836]

Lu, X.; Chen, D.; Yang, F.; Xing, N. Quercetin Inhibits Epithelial-to-Mesenchymal Transition (EMT) Process and Promotes Apoptosis in Prostate Cancer via Downregulating lncRNA MALAT1. Cancer Manag. Res., 2020, 12, 1741-1750.
[http://dx.doi.org/10.2147/CMAR.S241093] [PMID: 32210615]

Chen, M.; Xia, Z.; Chen, C.; Hu, W.; Yuan, Y. LncRNA MALAT1 promotes epithelial-to-mesenchymal transition of esophageal cancer through Ezh2-Notch1 signaling pathway. Anticancer Drugs, 2018, 29(8), 767-773.
[http://dx.doi.org/10.1097/CAD.0000000000000645] [PMID: 29916899]

Shen, L.; Chen, L.; Wang, Y.; Jiang, X.; Xia, H.; Zhuang, Z. Long noncoding RNA MALAT1 promotes brain metastasis by inducing epithelial-mesenchymal transition in lung cancer. J. Neurooncol., 2015, 121(1), 101-108.
[http://dx.doi.org/10.1007/s11060-014-1613-0] [PMID: 25217850]

Zhao, C.; Ling, X.; Xia, Y.; Yan, B.; Guan, Q. The m6A methyltransferase METTL3 controls epithelial-mesenchymal transition, migration and invasion of breast cancer through the MALAT1/miR-26b/HMGA2 axis. Cancer Cell Int., 2021, 21(1), 441.
[http://dx.doi.org/10.1186/s12935-021-02113-5] [PMID: 34419065]

Wang, Y.; Zhou, Y.; Yang, Z.; Chen, B.; Huang, W.; Liu, Y.; Zhang, Y. MiR-204/ZEB2 axis functions as key mediator for MALAT1-induced epithelial–mesenchymal transition in breast cancer. Tumour Biol., 2017, 39(7), 1010428317690998.
[http://dx.doi.org/10.1177/1010428317690998] [PMID: 28675122]

Xu, S.; Sui, S.; Zhang, J.; Bai, N.; Shi, Q.; Zhang, G.; Gao, S.; You, Z.; Zhan, C.; Liu, F.; Pang, D. Downregulation of long noncoding RNA MALAT1 induces epithelial-to-mesenchymal transition via the PI3K-AKT pathway in breast cancer. Int. J. Clin. Exp. Pathol., 2015, 8(5), 4881-4891.
[PMID: 26191181]

Gupta, S.C.; Mo, Y.Y. Abstract 168: MALAT1 is crucial for epithelial-mesenchymal transition of breast cancer cells in acidic microenvironment. Cancer Res., 2015, 75(S15), 168.
[http://dx.doi.org/10.1158/1538-7445.AM2015-168]

Chen, B.; Luo, L.; Wei, X.; Gong, D.; Li, Z.; Li, S.; Tang, W.; Jin, L. M1 Bone Marrow-Derived Macrophage-Derived Extracellular Vesicles Inhibit Angiogenesis and Myocardial Regeneration Following Myocardial Infarction via the MALAT1/MicroRNA-25-3p/CDC42 Axis. Oxid. Med. Cell. Longev., 2021, 2021, 1-26.
[http://dx.doi.org/10.1155/2021/9959746] [PMID: 34745428]

Tao, S.; Bai, Z.; Liu, Y.; Gao, Y.; Zhou, J.; Zhang, Y.; Li, J. Exosomes Derived from Tumor Cells Initiate Breast Cancer Cell Metastasis and Chemoresistance through a MALAT1-Dependent Mechanism. J. Oncol., 2022, 2022, 1-16.
[http://dx.doi.org/10.1155/2022/5483523] [PMID: 35813865]

Li, J.; Heravi, M.F.; Wu, X.; He, K. Mechanism of METTL14 and m6A modification of lncRNA MALAT1 in the proliferation of oral squamous cell carcinoma cells. Oral Dis., 2023, 29(5), 2012-2026.
[http://dx.doi.org/10.1111/odi.14220] [PMID: 35467063]

Liu, J.; Shi, Y.; Wu, M.; Zhang, F.; Xu, M.; He, Z.; Tang, M. JAG1 enhances angiogenesis in triple-negative breast cancer through promoting the secretion of exosomal lncRNA MALAT1. Genes Dis., 2023, 10(5), 2167-2178.
[http://dx.doi.org/10.1016/j.gendis.2022.07.006] [PMID: 37492742]

Huang, X.J.; Xia, Y.; He, G.F.; Zheng, L.L.; Cai, Y.P.; Yin, Y.; Wu, Q. MALAT1 promotes angiogenesis of breast cancer. Oncol. Rep., 2018, 40(5), 2683-2689.
[PMID: 30226550]

Geng, Q.; Xian, R.; Yu, Y.; Chen, F.; Li, R. SHP-1 acts as a tumor suppressor by interacting with EGFR and predicts the prognosis of human breast cancer. Cancer Biol. Med., 2021, 19(4), 468-485.
[http://dx.doi.org/10.20892/j.issn.2095-3941.2020.0501] [PMID: 34591414]

Toraih, E.A.; Wazir, E.A.; Ageeli, E.A.; Hussein, M.H.; Eltoukhy, M.M.; Killackey, M.T.; Kandil, E.; Fawzy, M.S. Unleash multifunctional role of long noncoding RNAs biomarker panel in breast cancer: A predictor classification model. Epigenomics, 2020, 12(14), 1215-1237.
[http://dx.doi.org/10.2217/epi-2019-0291] [PMID: 32812439]

Qin, Y.; Peng, F.; Ai, L.; Mu, S.; Li, Y.; Yang, C.; Hu, Y. Tumor-infiltrating B cells as a favorable prognostic biomarker in breast cancer: A systematic review and meta-analysis. Cancer Cell Int., 2021, 21(1), 310.
[http://dx.doi.org/10.1186/s12935-021-02004-9] [PMID: 34118931]

Berger, K.; Rhost, S.; Rafnsdóttir, S.; Hughes, É.; Magnusson, Y.; Ekholm, M.; Stål, O.; Rydén, L.; Landberg, G. Tumor co-expression of progranulin and sortilin as a prognostic biomarker in breast cancer. BMC Cancer, 2021, 21(1), 185.
[http://dx.doi.org/10.1186/s12885-021-07854-0] [PMID: 33618683]

Blockhuys, S.; Brady, D.C.; Stafshede, W.P. Evaluation of copper chaperone ATOX1 as prognostic biomarker in breast cancer. Breast Cancer, 2020, 27(3), 505-509.
[http://dx.doi.org/10.1007/s12282-019-01044-4] [PMID: 31898157]

Pickl, J.M.A.; Heckmann, D.; Ratz, L.; Klauck, S.M.; Sültmann, H. Novel RNA markers in prostate cancer: Functional considerations and clinical translation. BioMed Res. Int., 2014, 2014, 1-12.
[http://dx.doi.org/10.1155/2014/765207] [PMID: 25250334]

Chen, B.; Dragomir, M.P.; Yang, C.; Li, Q.; Horst, D.; Calin, G.A. Targeting non-coding RNAs to overcome cancer therapy resistance. Signal Transduct. Target. Ther., 2022, 7(1), 121.
[http://dx.doi.org/10.1038/s41392-022-00975-3] [PMID: 35418578]

Dashtaki, M.E.; Ghasemi, S. Anti-angiogenic Drug Resistance: Roles and Targeting of Non-coding RNAs (microRNAs and long non-coding RNAs). Curr. Mol. Pharmacol., 2023, 16(8), 855-869.
[PMID: 36475334]

Hussain, MS; Mohit, GK; Deb, A; Kataria, T Mini-review on personalized medicine: A revolution in health care. Precision Medicine Research, 2021, 3(4), 1-3.

Sharma, RK; Calderon, C; Mejia, V.PE Targeting Non-coding RNA for Glioblastoma Therapy: The Challenge of Overcomes the Blood-Brain Barrier. Frontiers in medical technology, 2021, 3, 678593.

Liao, Y.; Wu, X.; Wu, M.; Fang, Y.; Li, J.; Tang, W. Non-coding RNAs in lung cancer: Emerging regulators of angiogenesis. J. Transl. Med., 2022, 20(1), 349.
[http://dx.doi.org/10.1186/s12967-022-03553-x] [PMID: 35918758]

Shih, C.H.; Chuang, L.L.; Tsai, M.H.; Chen, L.H.; Chuang, E.Y.; Lu, T.P.; Lai, L.C. Hypoxia-Induced MALAT1 Promotes the Proliferation and Migration of Breast Cancer Cells by Sponging MiR-3064-5p. Front. Oncol., 2021, 11, 658151.
[http://dx.doi.org/10.3389/fonc.2021.658151] [PMID: 34012919]