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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Perspective

The Intra- and Intermolecular Friedel-Crafts Acylation of Amino Acid Derivatives in Stereo-retarded Manner

Author(s): Zetryana Puteri Tachrim* and Makoto Hashimoto*

Volume 28, Issue 16, 2024

Published on: 14 May, 2024

Page: [1225 - 1228] Pages: 4

DOI: 10.2174/0113852728317263240510114622

Price: $65

Abstract

The Friedel-Crafts acylation of natural or unnatural amino acids in stereoretarded manner is willing to prescribed here. Depending on its main skeleton, the typical intra- and intermolecular Friedel-Crafts reaction of amino acids can be differentiated. The unique amino acid’s general structure can contribute to the reaction between its carboxyl group and the side chain. Depending on the Friedel-Crafts reaction condition, the amino acid’s optical retention can be retarded. This perspective can contribute to the development of this one-century reaction in the field of organic chemistry.

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Graphical Abstract

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