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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Review Article

Recent Advances in Trifluoromethylation of Olefins, Aldehydes, and Ketones

Author(s): Mengran Bai, Liyuan Zhang, Lu Liu, Chenyu Jia, Yuting Zheng, Huijian Shang, Hui Sun* and Bin Cui*

Volume 28, Issue 16, 2024

Published on: 21 May, 2024

Page: [1229 - 1243] Pages: 15

DOI: 10.2174/0113852728305885240506155446

Price: $65

Abstract

Due to the robust electrophilic properties of the trifluoromethyl group (-CF3), its incorporation into organic compounds can markedly alter their ester affinity, stability, bioavailability, and other properties. The trifluoromethylation reaction is currently experiencing rapid advancement, with an expanding array of substrates and the emergence of novel methodologies. Consequently, compounds containing the -CF3 moiety find extensive utility across diverse fields. This article aims to comprehensively review the latest advancements in trifluoromethylation reaction of olefins, aldehydes, and ketones, encompassing nucleophilic trifluoromethylation, electrophilic trifluoromethylation, and radical trifluoromethylation. The discussion includes an exploration of the types and broadening scope of applicable substrates. Furthermore, this article addresses the associated challenges and delineates prospective directions for future developments in trifluoromethyl reaction.

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