Advances of Oxidative Stress Impact in Periodontitis: Biomarkers
and Effective Targeting Options

Chrysi      Pouliou; Christina      Piperi
doi:10.2174/0109298673297545240507091410
Abstract

Periodontitis is the most common inflammatory oral disease that affects around 15% of adults and contributes to severe periodontal tissue destruction with subsequent tooth loosening and loss. Among the main pathogenic mechanisms underlying periodontitis, excessive reactive oxygen species production and oxidative stress play a predominant role in inducing both local and systemic damage. Current therapeutic approaches have expanded the conventional methods combined with herbal antioxidant compounds to free radical-scavenging nanomaterials and infrared laser therapy, offering promising pre-clinical evidence in periodontitis management. Herein, we review the pathogenic mechanisms of reactive oxygen species tissue damage, along with recent advances in oxidative stress biomarkers and novel targeting options.
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DOI https://dx.doi.org/10.2174/0109298673297545240507091410	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
Current Medicinal Chemistry

Advances of Oxidative Stress Impact in Periodontitis: Biomarkers and Effective Targeting Options

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