Post-Translational Modifications in Tau and Their Roles in Alzheimer's
Pathology

Subha      Kalyaanamoorthy; Stanley Kojo      Opare; Xiaoxiao      Xu; Aravindhan      Ganesan; Praveen   P.N.   Rao
doi:10.2174/0115672050301407240408033046
Abstract

Microtubule-Associated Protein Tau (also known as tau) has been shown to accumulate into paired helical filaments and neurofibrillary tangles, which are known hallmarks of Alzheimer’s disease (AD) pathology. Decades of research have shown that tau protein undergoes extensive post-translational modifications (PTMs), which can alter the protein's structure, function, and dynamics and impact the various properties such as solubility, aggregation, localization, and homeostasis. There is a vast amount of information describing the impact and role of different PTMs in AD pathology and neuroprotection. However, the complex interplay between these PTMs remains elusive. Therefore, in this review, we aim to comprehend the key post-translational modifications occurring in tau and summarize potential connections to clarify their impact on the physiology and pathophysiology of tau. Further, we describe how different computational modeling methods have helped in understanding the impact of PTMs on the structure and functions of the tau protein. Finally, we highlight the tau PTM-related therapeutics strategies that are explored for the development of AD therapy.
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DOI https://dx.doi.org/10.2174/0115672050301407240408033046	Print ISSN 1567-2050
Publisher Name Bentham Science Publisher	Online ISSN 1875-5828
Current Alzheimer Research

Post-Translational Modifications in Tau and Their Roles in Alzheimer's Pathology

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