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Current Cardiology Reviews

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ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

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Meta-Analysis

Pro- and Anti-inflammatory Biomarkers Responses after Aerobic Training in Heart Transplant Recipients: A Systematic Review and Meta-analysis

Author(s): Leandro Tolfo Franzoni*, Stephanie Bastos da Motta, Gabriel Carvalho, Rochelle Rocha Costa, Mabel Marciela Ahner, Marco Aurélio Lumertz Saffi, Alexandre Araújo Pereira, Adamastor Humberto Pereira, Anderson Donelli da Silveira and Ricardo Stein

Volume 20, Issue 5, 2024

Published on: 02 April, 2024

Article ID: e020424228544 Pages: 8

DOI: 10.2174/011573403X269909240320061952

Price: $65

Abstract

Background: Physical exercise (PE) may improve plasma concentration of interleukin- 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and adiponectin (adpN) in heart transplant (HT) patients. However, no consistent data is available on this population.

Aim: Thus, we aimed to conduct a systematic review and meta-analysis on the effects of PE over these pro- and anti-inflammatory biomarkers in HT patients.

Methods: Following the guidelines established by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement, we conducted a systematic literature search in the PubMed, Cochrane, and Scopus databases. Outcomes included IL-6, TNF-alpha, and adpN. Effect size (ES) was calculated using the standardized mean difference with a 95% confidence interval (CI).

Results: The PE group (aerobic modality) was associated with reduced IL-6 compared to the control group (ES: −0.53; 95% CI: −0.99 to −0.06 pg/mL; P = 0.026). However, the PE group did not show a significant effect on TNF-alpha and adpN levels (ES: −0.33; 95% CI: −0.79 to 0.13; P = 0.16 and ES: −0.20; 95% CI: −0.70 to 0.30 pg/mL; P = 0.444, respectively).

Conclusion: PE is associated with IL-6 reductions, although TNF alpha and adpN did not change after this intervention in HT patients. Therefore, PE is an effective intervention to downregulate IL-6 in post-HT patients.

Graphical Abstract

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