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ISSN (Online): 2665-9794

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Research Article

Preparation and Evaluation of Nutraceutical Capsules of Sunflower Seed Extracts for the Treatment of Anemia

Author(s): Salome Amarachi Chime* and Chinenye Justy Okoye

Volume 5, 2024

Published on: 19 March, 2024

Article ID: e190324228140 Pages: 10

DOI: 10.2174/0126659786291061240228074957

Price: $65

Abstract

Aims: The study aimed to develop pharmaceutical nutraceutical capsules containing extracts from sunflower seeds to treat anemia and associated diseases. Sunflower seed extract (SFSE) was obtained from Helianthus annuus L, and the phytochemicals, antioxidant vitamins and mineral compositions were evaluated.

Methods: Pharmaceutics evaluations were analyzed using the dried extracts to determine their flowability. The extracts were further formulated into capsule dosage forms and evaluated. The phytochemical screening of sunflower seed extract and powdered crude indicated the presence of tannin, flavonoid, phenol, saponins, phytate, oxalate, alkaloids and steroids. The quantitative phytochemical composition of sunflower seed extract revealed a high alkaloid content of 11.80 ± 0.02%, steroid composition of 2.80 ± 0.01% and a phenolic compound of 0.02 ± 0.00%. SFSE also showed different amounts of antioxidants, vitamins A, C, and E. Vitamin C (1924.20 μg/mg) was significantly the highest (p<0.05), followed by vitamin E (42.01±1.02 μg/mg), and the least was vitamin A (18.01 μg/mg). The micromeritics studies of the dried powdered extract revealed an excellent flow. The extracts were adequately formulated in capsules using hard-shell gelatin capsules in combination with compatible pharmaceutical-grade excipients. The uniformity of capsule weight showed an average weight of 488 mg ± 0.7377% and 492 mg ± 0.3252%.

Results: The data obtained from the extracts' content analysis showed that the extracts and all their constituents were neither affected by formulation procedures nor excipients. Hence, they exhibited an average content of 98 ± 0.07%. Zinc, iron, copper, manganese, and selenium in sunflower seeds could provide antioxidants, which can safely interact with free radicals and terminate the chain reaction, improving health status and the blood's red blood cell composition.

Conclusion: SFSE capsules were stable and could be used to mask the taste and odor of this extract to enhance patient compliance.

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