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Current Traditional Medicine

Editor-in-Chief

ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

Review Article

Immunomodulator Drugs in Unani Medicine: Evidence from Preclinical and Clinical Research

In Press, (this is not the final "Version of Record"). Available online 26 February, 2024
Author(s): Hamiduddin*, Sabeena Shah, Malik Itrat, Zaigham and Uzair Ahmed
Published on: 26 February, 2024

Article ID: e260224227412

DOI: 10.2174/0122150838272561240204134021

Price: $95

Abstract

The immune system is one of our most intricate biological systems, maintaining bodily homeostasis. Substances that modulate the immune responses are called immunomodulators. In Unani system of medicine (USM), immunity is referred to as Quwate-Mudafia, which is part of Quwa and is maintained by Tabiyat. In Unani literature, many single drugs and formulations have been used for their immunomodulatory effect, apart from other therapeutic properties. Single Unani drugs with established immunomodulatory activity are Gilo (Tinospora cordifolia), Sibr (Aloe vera), Asgandh (Withania somnifera), Aamla (Emblica officinalis) etc. Compound formulations are Jawarish Amla sada, Iksir-e-badan, etc. We are living in the age of evermutating influenza viruses giving challenges to mankind (such as the recently prevailed SARSCoV- 2 pandemic); many Unani medicinal plants are still unexplored and need to be evaluated for their immunomodulatory property, which can act as substitutes for conventional drugs. To compile Unani immunomodulatory drugs under one heading, important critical texts of traditional Unani medicine, indexed peer-reviewed journals, and authentic literature from online sources were reviewed along with their reported in vivo/in vitro activities and clinical trials. Unani drugs explored in this review are time-tested remedies and can be utilized in these rapidly changing immunological challenges.


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