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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Review Article

Deleterious Biological Effects of Endocrine Disruptors: An Insight into Human Health Risks

Author(s): Abdullah Al Lawati, Lubna Al Hashmi, Husain Al Aswami, Abdulrahman Al Hadhrami, Kok-Yong Chin, Srinivasa Rao Sirasanagandla and Srijit Das*

Volume 24, Issue 13, 2024

Published on: 30 January, 2024

Page: [1471 - 1479] Pages: 9

DOI: 10.2174/0118715303279298231228074222

Price: $65

Abstract

Endocrine-disrupting chemicals (EDCs) are environmental pollutants. Since EDCs are present in various consumer products, contamination of human beings is very common. EDCs have deleterious effects on various systems of the body, especially the endocrine and reproductive systems. EDCs interfere with the synthesis, metabolism, binding, or cellular responses of natural estrogens and alter various pathways. Biological samples such as blood, saliva, milk, placental tissue, and hair are frequently used for biomonitoring and the detection of EDCs. Early detection and intervention may help in preventing congenital anomalies and birth defects. The common methods for determining the presence of EDCs in body fluids include gas chromatography, high-performance liquid chromatography, and mass spectrometry. Understanding the health effects and dangers of EDC is important, given their widespread use. This mini-review aims to summarize the adverse biological effects of several important classes of EDCs and highlights future perspectives for appropriate control.

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Graphical Abstract

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