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Abstract
Background: During the Covid-19 pandemic, people's lives worldwide have undergone extensive changes. The pandemic has worsened the condition of patients with chronic diseases like women with endometriosis. Objective: This study aims to summarize available evidence on the impact of the COVID-19 pandemic on physical symptoms, mental health, and medical care of patients with endometriosis.
Methods: In the present integrative review using PRISMA guidelines, related articles published from December 2019 to July 2023 in databases including MEDLINE, Science Direct, Scopus, and Google Scholar in the English language were extracted.
Results: After evaluating the criteria for inclusion and exclusion, a total of 23 articles were chosen and examined. This study represents an open window to investigate the impact of COVID-19 on women with endometriosis. The COVID-19 pandemic has affected the symptoms, mental well-being, and medical care of women with endometriosis.
Conclusions: There is a perceived necessity to provide supportive care for patients during pandemic restrictions. Remote work has had an unanticipated advantage, and it is recommended that women with endometriosis continue to work from home after COVID-19 to maintain their workplace effectiveness.
[1]
Schwab, R.; Anić, K.; Stewen, K.; Schmidt, M.W.; Kalb, S.R.; Kottmann, T.; Brenner, W.; Domidian, J.S.; Krajnak, S.; Battista, M.J.; Hasenburg, A. Pain experience and social support of endometriosis patients during the COVID-19 pandemic in Germany-results of a web-based cross-sectional survey. PLoS One, 2021, 16(8), e0256433.
[http://dx.doi.org/10.1371/journal.pone.0256433] [PMID: 34432847]
[http://dx.doi.org/10.1371/journal.pone.0256433] [PMID: 34432847]
[2]
Spinelli, A.; Pellino, G. COVID-19 pandemic: Perspectives on an unfolding crisis. Br. J. Surg., 2020, 107(7), 785-787.
[http://dx.doi.org/10.1002/bjs.11627] [PMID: 32191340]
[http://dx.doi.org/10.1002/bjs.11627] [PMID: 32191340]
[3]
Mulita, F.; Vailas, M.; Tchabashvili, L.; Liolis, E.; Iliopoulos, F.; Drakos, N The impact of the COVID-19 outbreak on emergency surgery: A Greek emergency department experience. Prz Gastroenterol., 2021, 16(1), 95.
[4]
Mulita, F.; Sotiropoulou, M.; Vailas, M. A multifaceted virus. Non-reducible and strangulated effects of COVID-19. J. Trauma Acute Care Surg., 2021, 91(1), e34.
[http://dx.doi.org/10.1097/TA.0000000000003219] [PMID: 33797481]
[http://dx.doi.org/10.1097/TA.0000000000003219] [PMID: 33797481]
[5]
Demetriou, L.; Cox, E.; Lunde, CE.; Becker, CM.; Invitti, AL.; Martínez-Burgo, B The global impact of COVID-19 on the care of people with endometriosis. Frontiers in global women' s health, 2021, 65.
[6]
Yalçın Bahat, P.; Kaya, C.; Selçuki, N.F.T.; Polat, İ.; Usta, T.; Oral, E. The COVID-19 pandemic and patients with endometriosis: A survey-based study conducted in Turkey. Int. J. Gynaecol. Obstet., 2020, 151(2), 249-252.
[http://dx.doi.org/10.1002/ijgo.13339] [PMID: 32750726]
[http://dx.doi.org/10.1002/ijgo.13339] [PMID: 32750726]
[7]
Namazi, M.; Zareiyan, A.; Jafarabadi, M.; Behboodi Moghadam, Z. Endometriosis reproductive health questionnaire (ERHQ): A self-administered questionnaire to measure the reproductive health in women with endometriosis. J. Gynecol. Obstet. Hum. Reprod., 2021, 50(3), 101860.
[http://dx.doi.org/10.1016/j.jogoh.2020.101860] [PMID: 32652304]
[http://dx.doi.org/10.1016/j.jogoh.2020.101860] [PMID: 32652304]
[8]
Namazi, M.; Behboodi Moghadam, Z.; Zareiyan, A.; Jafarabadi, M. Impact of endometriosis on reproductive health: An integrative review. J. Obstet. Gynaecol., 2021, 41(8), 1183-1191.
[http://dx.doi.org/10.1080/01443615.2020.1862772] [PMID: 33645413]
[http://dx.doi.org/10.1080/01443615.2020.1862772] [PMID: 33645413]
[9]
Namazi, M.; Behboodi Moghadam, Z.; Zareiyan, A.; Jafarabadi, M. Exploring the impact of endometriosis on women’s lives: A qualitative study in Iran. Nurs. Open, 2021, 8(3), 1275-1282.
[http://dx.doi.org/10.1002/nop2.744] [PMID: 33354928]
[http://dx.doi.org/10.1002/nop2.744] [PMID: 33354928]
[10]
Kvaskoff, M.; Mahamat-Saleh, Y.; Farland, L.V.; Shigesi, N.; Terry, K.L.; Harris, H.R.; Roman, H.; Becker, C.M.; As-Sanie, S.; Zondervan, K.T.; Horne, A.W.; Missmer, S.A. Endometriosis and cancer: A systematic review and meta-analysis. Hum. Reprod. Update, 2021, 27(2), 393-420.
[http://dx.doi.org/10.1093/humupd/dmaa045] [PMID: 33202017]
[http://dx.doi.org/10.1093/humupd/dmaa045] [PMID: 33202017]
[11]
Zandi, N.; Behboodi Moghadam, Z.; Hossein Rashidi, B.; Namazi, M.; Haghani, S. Reproductive health of women with endometriosis: An improving educational intervention based on the planned behavior theory. Middle East Fertil. Soc. J., 2023, 28(1), 4.
[http://dx.doi.org/10.1186/s43043-023-00129-7] [PMID: 36852092]
[http://dx.doi.org/10.1186/s43043-023-00129-7] [PMID: 36852092]
[12]
Ashkenazi, S.; Huseby, O.L.; Kroken, G.; Soto-Mota, A.; Pents, M.; Loschiavo, A. COVID-19 compromises in the medical practice and the consequential effect on endometriosis patients. medRxiv, 2021, 2021.05.
[http://dx.doi.org/10.1101/2021.05.04.21255000]
[http://dx.doi.org/10.1101/2021.05.04.21255000]
[13]
Evans, S.; Dowding, C.; Druitt, M.; Mikocka-Walus, A. “I’m in iso all the time anyway”: A mixed methods study on the impact of COVID-19 on women with endometriosis. J. Psychosom. Res., 2021, 146, 110508.
[http://dx.doi.org/10.1016/j.jpsychores.2021.110508] [PMID: 33993063]
[http://dx.doi.org/10.1016/j.jpsychores.2021.110508] [PMID: 33993063]
[14]
Kontoangelos, K.; Economou, M.; Papageorgiou, C. Mental health effects of COVID-19 pandemia: A review of clinical and psychological traits. Psychiatry Investig., 2020, 17(6), 491-505.
[http://dx.doi.org/10.30773/pi.2020.0161] [PMID: 32570296]
[http://dx.doi.org/10.30773/pi.2020.0161] [PMID: 32570296]
[15]
Akat, M.; Karataş, K. Psychological effects of COVID-19 pandemic on society and ıts reflections on education; Electronic Turkish Studies, 2020.
[16]
Lewin, J.; Saridogan, E.; Byrne, D.; Clark, T.J.; Vashisht, A. Impact of the COVID-19 pandemic on surgery for severe endometriosis in the UK: A national database study. Facts Views Vis. ObGyn, 2022, 14(4), 309-315.
[http://dx.doi.org/10.52054/FVVO.14.4.043] [PMID: 36724422]
[http://dx.doi.org/10.52054/FVVO.14.4.043] [PMID: 36724422]
[17]
Page, M.J.; McKenzie, J.E.; Bossuyt, P.M.; Boutron, I.; Hoffmann, T.C.; Mulrow, C.D.; Shamseer, L.; Tetzlaff, J.M.; Moher, D. Updating guidance for reporting systematic reviews: Development of the PRISMA 2020 statement. J. Clin. Epidemiol., 2021, 134, 103-112.
[http://dx.doi.org/10.1016/j.jclinepi.2021.02.003] [PMID: 33577987]
[http://dx.doi.org/10.1016/j.jclinepi.2021.02.003] [PMID: 33577987]
[20]
Arena, A.; Orsini, B.; Degli Esposti, E.; Raimondo, D.; Lenzi, J.; Verrelli, L.; Iodice, R.; Casadio, P.; Seracchioli, R. Effects of the SARS-CoV-2 pandemic on women affected by endometriosis: A large cross-sectional online survey. Ann. Med., 2021, 53(1), 1924-1934.
[http://dx.doi.org/10.1080/07853890.2021.1991589] [PMID: 34714186]
[http://dx.doi.org/10.1080/07853890.2021.1991589] [PMID: 34714186]
[21]
Armour, M.; Ciccia, D.; Stoikos, C.; Wardle, J. Endometriosis and the workplace: Lessons from Australia’s response to COVID-19. Aust. N. Z. J. Obstet. Gynaecol., 2022, 62(1), 164-167.
[http://dx.doi.org/10.1111/ajo.13458] [PMID: 34811735]
[http://dx.doi.org/10.1111/ajo.13458] [PMID: 34811735]
[22]
Barra, F.; La Rosa, V.L.; Vitale, S.G.; Commodari, E.; Altieri, M.; Scala, C.; Ferrero, S. Psychological status of infertile patients who had in vitro fertilization treatment interrupted or postponed due to COVID-19 pandemic: A cross-sectional study. J. Psychosom. Obstet. Gynaecol., 2022, 43(2), 145-152.
[http://dx.doi.org/10.1080/0167482X.2020.1853095] [PMID: 33252292]
[http://dx.doi.org/10.1080/0167482X.2020.1853095] [PMID: 33252292]
[23]
Crispi, CP.; de Almeida Nogueira, E.; Balthar, PC.; Guerra, CGS; de Freitas Fonseca, M. Endometriosis surgery during the first wave of the COVID-19 pandemic: A Brazilian single institution experience. Case Rep. Obstet. Gynecol., 2021, 2021, 5040873.
[http://dx.doi.org/10.1155/2021/5040873]
[http://dx.doi.org/10.1155/2021/5040873]
[24]
Gupta, S.; Maghsoudlou, P.; Ajao, M.; Ivar Einarsson, J.; Perkins King, L. Analysis of COVID-19 response and impact on gynecologic surgery at a large academic hospital system. JSLS, 2021, 25(4), e2021.00056.
[http://dx.doi.org/10.4293/JSLS.2021.00056] [PMID: 34803367]
[http://dx.doi.org/10.4293/JSLS.2021.00056] [PMID: 34803367]
[25]
Ramos-Echevarría, P.M.; Soto-Soto, D.M.; Torres-Reverón, A.; Appleyard, C.B.; Akkawi, T.; Barros-Cartagena, B.D.; López-Rodríguez, V.; Castro-Figueroa, E.M.; Flores-Caldera, I. Impact of the early COVID-19 era on endometriosis patients: Symptoms, stress, and access to care. J. Endometr. Pelvic Pain Disord., 2021, 13(2), 111-121.
[http://dx.doi.org/10.1177/22840265211009634]
[http://dx.doi.org/10.1177/22840265211009634]
[26]
Rosielle, K.; Bergwerff, J.; Schreurs, A.M.F.; Knijnenburg, J.; De Bie, B.; Maas, J.W.M.; Nap, A.W.; van Wely, M.; Lambalk, C.B.; Goddijn, M.; Custers, I.M.; van Loendersloot, L.L.; Mijatovic, V. The impact of the COVID-19 pandemic on infertility patients and endometriosis patients in the Netherlands. Reprod. Biomed. Online, 2021, 43(4), 747-755.
[http://dx.doi.org/10.1016/j.rbmo.2021.06.001] [PMID: 34404622]
[http://dx.doi.org/10.1016/j.rbmo.2021.06.001] [PMID: 34404622]
[27]
Armour, M.; Sinclair, J.; Cheng, J.; Davis, P.; Hameed, A.; Meegahapola, H.; Rajashekar, K.; Suresh, S.; Proudfoot, A.; Leonardi, M. Endometriosis and cannabis consumption during the COVID-19 pandemic: An international cross-sectional survey. Cannabis Cannabinoid Res., 2022, 7(4), 473-481.
[http://dx.doi.org/10.1089/can.2021.0162] [PMID: 35089093]
[http://dx.doi.org/10.1089/can.2021.0162] [PMID: 35089093]
[28]
Ashkenazi, M.S.; Huseby, O.L.; Kroken, G.; Soto-Mota, A.; Pents, M.; Loschiavo, A.; Lewandowska, R.; Tran, G.; Kwiatkowski, S. COVID-19 pandemic and the consequential effect on patients with endometriosis. Hum. Reprod. Open, 2022, 2022(2), hoac013.
[http://dx.doi.org/10.1093/hropen/hoac013] [PMID: 35386120]
[http://dx.doi.org/10.1093/hropen/hoac013] [PMID: 35386120]
[29]
Demetriou, L.; Becker, C.M.; Martínez-Burgo, B.; Invitti, A.L.; Kvaskoff, M.; Shah, R.; Evans, E.; Lunde, C.E.; Cox, E.; Garbutt, K.; Zondervan, K.T.; Fox, E.; Vincent, K. Stressful experiences impact clinical symptoms in people with endometriosis. Reproduction and Fertility, 2022, 3(4), 262-272.
[http://dx.doi.org/10.1530/RAF-22-0028]
[http://dx.doi.org/10.1530/RAF-22-0028]
[30]
Nicolás, I.; Martínez-Zamora, M.Á.; Gracia, M.; Feixas, G.; Rius, M.; Carmona, F. Impact of SARS-COV2 pandemic on patients with endometriosis and their health care. J. Womens Health, 2022, 31(4), 480-486.
[http://dx.doi.org/10.1089/jwh.2021.0323] [PMID: 35148487]
[http://dx.doi.org/10.1089/jwh.2021.0323] [PMID: 35148487]
[31]
Schwab, R.; Stewen, K.; Ost, L.; Kottmann, T.; Theis, S.; Elger, T.; Schmidt, M.W.; Anic, K.; Kalb, S.R.; Brenner, W.; Hasenburg, A. Predictors of psychological distress in women with endometriosis during the COVID-19 pandemic. Int. J. Environ. Res. Public Health, 2022, 19(8), 4927.
[http://dx.doi.org/10.3390/ijerph19084927] [PMID: 35457794]
[http://dx.doi.org/10.3390/ijerph19084927] [PMID: 35457794]
[32]
Schwab, R.; Stewen, K.; Kottmann, T.; Theis, S.; Elger, T.; Hamoud, B.H.; Schmidt, M.W.; Anic, K.; Brenner, W.; Hasenburg, A. Determinants of pain-induced disability in German women with endometriosis during the COVID-19 pandemic. Int. J. Environ. Res. Public Health, 2022, 19(14), 8277.
[http://dx.doi.org/10.3390/ijerph19148277] [PMID: 35886130]
[http://dx.doi.org/10.3390/ijerph19148277] [PMID: 35886130]
[33]
Schwab, R.; Stewen, K.; Kottmann, T.; Schmidt, M.W.; Anic, K.; Theis, S.; Hamoud, B.H.; Elger, T.; Brenner, W.; Hasenburg, A. Factors associated with increased analgesic use in German women with endometriosis during the COVID-19 pandemic. J. Clin. Med., 2022, 11(19), 5520.
[http://dx.doi.org/10.3390/jcm11195520] [PMID: 36233387]
[http://dx.doi.org/10.3390/jcm11195520] [PMID: 36233387]
[34]
Spencer, J.I.; Mezquita, G.; Shakir, F. The ongoing impact of the COVID-19 pandemic on endometriosis patients: A survey of 1,089 UK patients. Facts Views Vis. ObGyn, 2022, 14(3), 257-264.
[http://dx.doi.org/10.52054/FVVO.14.3.037] [PMID: 36206800]
[http://dx.doi.org/10.52054/FVVO.14.3.037] [PMID: 36206800]
[35]
Waters, N.; Taffs, L.; Marino, J.L.; Rapsey, C.; Girling, J.E.; Peate, M. Unmet needs in endometriosis: Lessons from COVID-19. Women’s Health Reports, 2022, 3(1), 937-943.
[http://dx.doi.org/10.1089/whr.2022.0051] [PMID: 36479376]
[http://dx.doi.org/10.1089/whr.2022.0051] [PMID: 36479376]
[36]
Liu, S.; Hou, C.; Tang, S.; Bai, S.; Deng, Y. Patients with endometriosis may experience worse clinical manifestations and therapeutic outcomes during COVID-19 in western China-a case series comparative analysis. BMC Womens Health, 2023, 23(1), 1-9.
[http://dx.doi.org/10.1186/s12905-022-02134-w] [PMID: 36593459]
[http://dx.doi.org/10.1186/s12905-022-02134-w] [PMID: 36593459]
[37]
Baciu, I.; Irimie-Ana, A.; Panaitescu, A.; Peltecu, G.; Gica, C.; Gica, N. The social and the psychological impact of endometriosis on the Romanian urban population. J Mind Med Sci, 2021, 8(1), 120-126.
[http://dx.doi.org/10.22543/7674.81.P120126]
[http://dx.doi.org/10.22543/7674.81.P120126]
[38]
Facchin, F.; Buggio, L.; Vercellini, P.; Frassineti, A.; Beltrami, S.; Saita, E. Quality of intimate relationships, dyadic coping, and psychological health in women with endometriosis: Results from an online survey. J. Psychosom. Res., 2021, 146, 110502.
[http://dx.doi.org/10.1016/j.jpsychores.2021.110502] [PMID: 33932718]
[http://dx.doi.org/10.1016/j.jpsychores.2021.110502] [PMID: 33932718]
[39]
Missmer, S.A.; Tu, F.F.; Agarwal, S.K.; Chapron, C.; Soliman, A.M.; Chiuve, S.; Eichner, S.; Flores-Caldera, I.; Horne, A.W.; Kimball, A.B.; Laufer, M.R.; Leyland, N.; Singh, S.S.; Taylor, H.S.; As-Sanie, S. Impact of endometriosis on life-course potential: A narrative review. Int. J. Gen. Med., 2021, 14, 9-25.
[http://dx.doi.org/10.2147/IJGM.S261139] [PMID: 33442286]
[http://dx.doi.org/10.2147/IJGM.S261139] [PMID: 33442286]
[40]
Sharp, G.C.; Fraser, A.; Sawyer, G.; Kountourides, G.; Easey, K.E.; Ford, G.; Olszewska, Z.; Howe, L.D.; Lawlor, D.A.; Alvergne, A.; Maybin, J.A. The COVID-19 pandemic and the menstrual cycle: research gaps and opportunities. Int. J. Epidemiol., 2022, 51(3), 691-700.
[http://dx.doi.org/10.1093/ije/dyab239] [PMID: 34865021]
[http://dx.doi.org/10.1093/ije/dyab239] [PMID: 34865021]
[41]
Bernays, V.; Schwartz, A.K.; Geraedts, K.; Rauchfuss, M.; Wölfler, M.M.; Haeberlin, F.; von Orelli, S.; Eberhard, M.; Imthurn, B.; Fink, D.; Imesch, P.; Leeners, B. Qualitative and quantitative aspects of sex life in the context of endometriosis: A multicentre case control study. Reprod. Biomed. Online, 2020, 40(2), 296-304.
[http://dx.doi.org/10.1016/j.rbmo.2019.10.015] [PMID: 31954612]
[http://dx.doi.org/10.1016/j.rbmo.2019.10.015] [PMID: 31954612]
[42]
Shum, L.K.; Bedaiwy, M.A.; Allaire, C.; Williams, C.; Noga, H.; Albert, A.; Lisonkova, S.; Yong, P.J. Deep dyspareunia and sexual quality of life in women with endometriosis. Sex. Med., 2018, 6(3), 224-233.
[http://dx.doi.org/10.1016/j.esxm.2018.04.006] [PMID: 29801714]
[http://dx.doi.org/10.1016/j.esxm.2018.04.006] [PMID: 29801714]
[43]
Pérez-López, F.R.; Ornat, L.; Pérez-Roncero, G.R.; López-Baena, M.T.; Sánchez-Prieto, M.; Chedraui, P. The effect of endometriosis on sexual function as assessed with the female sexual function index: systematic review and meta-analysis. Gynecol. Endocrinol., 2020, 36(11), 1015-1023.
[http://dx.doi.org/10.1080/09513590.2020.1812570] [PMID: 32880200]
[http://dx.doi.org/10.1080/09513590.2020.1812570] [PMID: 32880200]
[44]
Leonardi, M.; Horne, A.W.; Vincent, K.; Sinclair, J.; Sherman, K.A.; Ciccia, D.; Condous, G.; Johnson, N.P.; Armour, M. Self-management strategies to consider to combat endometriosis symptoms during the COVID-19 pandemic. Hum. Reprod. Open, 2020, 2020(2), hoaa028.
[http://dx.doi.org/10.1093/hropen/hoaa028] [PMID: 32509977]
[http://dx.doi.org/10.1093/hropen/hoaa028] [PMID: 32509977]
[45]
Agarwal, SK.; Chapron, C.; Giudice, LC.; Laufer, MR.; Leyland, N.; Missmer, SA Clinical diagnosis of endometriosis: A call to action. Am. J. Obstet. Gynecol., 2019, 220(4), 354.e1-354.e12.
[http://dx.doi.org/10.1016/j.ajog.2018.12.039]
[http://dx.doi.org/10.1016/j.ajog.2018.12.039]
[46]
Chapron, C.; Marcellin, L.; Borghese, B.; Santulli, P. Rethinking mechanisms, diagnosis and management of endometriosis. Nat. Rev. Endocrinol., 2019, 15(11), 666-682.
[http://dx.doi.org/10.1038/s41574-019-0245-z] [PMID: 31488888]
[http://dx.doi.org/10.1038/s41574-019-0245-z] [PMID: 31488888]
[47]
Ghai, V.; Jan, H.; Shakir, F.; Haines, P.; Kent, A. Diagnostic delay for superficial and deep endometriosis in the United Kingdom. J. Obstet. Gynaecol., 2020, 40(1), 83-89.
[http://dx.doi.org/10.1080/01443615.2019.1603217] [PMID: 31328629]
[http://dx.doi.org/10.1080/01443615.2019.1603217] [PMID: 31328629]
