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Current Topics in Medicinal Chemistry

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ISSN (Online): 1873-4294

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Review Article

The Neurobiology of Formal Thought Disorder

Author(s): Erik Dornelles* and Diogo Telles Correia

Volume 24, Issue 20, 2024

Published on: 18 January, 2024

Page: [1773 - 1783] Pages: 11

DOI: 10.2174/0115680266272521240108102354

Price: $65

Abstract

The concept of Formal Thought Disorder (FTD) is an ambiguous and disputed one, even though it has endured as a core psychopathological construct in clinical Psychiatry. FTD can be summarized as a multidimensional construct, reflecting difficulties or idiosyncrasies in thinking, language, and communication in general and is usually subdivided into positive versus negative. In this article, we aim to explore the putative neurobiology of FTD, ranging from changes in neurotransmitter systems to alterations in the functional anatomy of the brain. We also discuss recent critiques of the operationalist view of FTD and how they might fit in its biological underpinnings.

We conclude that FTD might be the observable phenotype of many distinct underlying alterations in different proportions.

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[1]
Jerónimo, J.; Queirós, T.; Cheniaux, E.; Telles-Correia, D. Formal thought disorders-historical roots. Front. Psychiatry, 2018, 9, 572.
[http://dx.doi.org/10.3389/fpsyt.2018.00572] [PMID: 30473667]
[2]
Berrios, G.E. The History of Mental Symptoms: Descriptive Psychopathology since the Nineteenth Century. Cambridge University Press, 1996.
[3]
Kircher, T.; Bröhl, H.; Meier, F.; Engelen, J. Formal thought disorders: From phenomenology to neurobiology. Lancet Psychiatry, 2018, 5(6), 515-526.
[http://dx.doi.org/10.1016/S2215-0366(18)30059-2] [PMID: 29678679]
[4]
Andreasen, N.C. Thought, language, and communication disorders. II. Diagnostic significance. Arch. Gen. Psychiatry, 1979, 36(12), 1325-1330.
[http://dx.doi.org/10.1001/archpsyc.1979.01780120055007] [PMID: 496552]
[5]
Holzman, P.S.; Shenton, M.E.; Solovay, M.R. Quality of thought disorder in differential diagnosis. Schizophr. Bull., 1986, 12(3), 360-372.
[http://dx.doi.org/10.1093/schbul/12.3.360] [PMID: 3764357]
[6]
Docherty, N.M.; DeRosa, M.; Andreasen, N.C. Communication disturbances in schizophrenia and mania. Arch. Gen. Psychiatry, 1996, 53(4), 358-364.
[http://dx.doi.org/10.1001/archpsyc.1996.01830040094014] [PMID: 8634014]
[7]
Yalincetin, B.; Bora, E.; Binbay, T.; Ulas, H.; Akdede, B.B.; Alptekin, K. Formal thought disorder in schizophrenia and bipolar disorder: A systematic review and meta-analysis. Schizophr. Res., 2017, 185, 2-8.
[http://dx.doi.org/10.1016/j.schres.2016.12.015] [PMID: 28017494]
[8]
Burbridge, J.A.; Larsen, R.J.; Barch, D.M. Affective reactivity in language: The role of psychophysiological arousal. Emotion, 2005, 5(2), 145-153.
[http://dx.doi.org/10.1037/1528-3542.5.2.145] [PMID: 15982080]
[9]
Andreasen, N.C. Scale for the assessment of thought, language, and communication (TLC). Schizophr. Bull., 1986, 12(3), 473-482.
[http://dx.doi.org/10.1093/schbul/12.3.473] [PMID: 3764363]
[10]
Kircher, T.; Krug, A.; Stratmann, M.; Ghazi, S.; Schales, C.; Frauenheim, M.; Turner, L.; Fährmann, P.; Hornig, T.; Katzev, M.; Grosvald, M.; Müller-Isberner, R.; Nagels, A. A rating scale for the assessment of objective and subjective formal Thought and Language Disorder (TALD). Schizophr. Res., 2014, 160(1-3), 216-221.
[http://dx.doi.org/10.1016/j.schres.2014.10.024] [PMID: 25458572]
[11]
Hart, M.; Lewine, R.R.J. Rethinking thought disorder. Schizophr. Bull., 2017, 43(3), 514-522.
[http://dx.doi.org/10.1093/schbul/sbx003] [PMID: 28204762]
[12]
Andreasen, N.C.; Grove, W.M. Thought, language, and communication in schizophrenia: diagnosis and prognosis. Schizophr. Bull., 1986, 12(3), 348-359.
[http://dx.doi.org/10.1093/schbul/12.3.348] [PMID: 3764356]
[13]
Morgan, C.J.; Coleman, M.J.; Ulgen, A.; Boling, L.; Cole, J.O.; Johnson, F.V.; Lerbinger, J.; Bodkin, J.A.; Holzman, P.S.; Levy, D.L. Thought disorder in schizophrenia and bipolar disorder probands, their relatives, and nonpsychiatric controls. Schizophr. Bull., 2017, 43(3), 523-535.
[http://dx.doi.org/10.1093/schbul/sbx016] [PMID: 28338967]
[14]
Harvey, P.D.; Docherty, N.M.; Serper, M.R.; Rasmussen, M. Cognitive deficits and thought disorder: II. An 8-month followup study. Schizophr. Bull., 1990, 16(1), 147-156.
[http://dx.doi.org/10.1093/schbul/16.1.147] [PMID: 2333475]
[15]
Ott, S.; Roberts, S.; Rock, D.; Allen, J.; Erlenmeyerkimling, L. Positive and negative thought disorder and psychopathology in childhood among subjects with adulthood schizophrenia. Schizophr. Res., 2002, 58(2-3), 231-239.
[http://dx.doi.org/10.1016/S0920-9964(01)00339-5] [PMID: 12409163]
[16]
Strik, W.; Dierks, T. Neurophysiological mechanisms of psychotic symptoms. Eur. Arch. Psychiatry Clin. Neurosci., 2008, 258(S5)(Suppl. 5), 66-70.
[http://dx.doi.org/10.1007/s00406-008-5016-0] [PMID: 18985298]
[17]
Palaniyappan, L. Dissecting the neurobiology of linguistic disorganisation and impoverishment in schizophrenia. Semin. Cell Dev. Biol., 2022, 129, 47-60.
[http://dx.doi.org/10.1016/j.semcdb.2021.08.015] [PMID: 34507903]
[18]
Strik, W.; Dierks, T.; Hubl, D.; Horn, H. Hallucinations, thought disorders, and the language domain in schizophrenia. Clin. EEG Neurosci., 2008, 39(2), 91-94.
[http://dx.doi.org/10.1177/155005940803900214] [PMID: 18450176]
[19]
Chang, X.; Zhao, W.; Kang, J.; Xiang, S.; Xie, C.; Corona-Hernández, H.; Palaniyappan, L.; Feng, J. Language abnormalities in schizophrenia: Binding core symptoms through contemporary empirical evidence. Schizophrenia, 2022, 8(1), 95.
[http://dx.doi.org/10.1038/s41537-022-00308-x] [PMID: 36371445]
[20]
Sommer, I.E.; Derwort, A.M.C.; Daalman, K.; de Weijer, A.D.; Liddle, P.F.; Boks, M.P.M. Formal thought disorder in non-clinical individuals with auditory verbal hallucinations. Schizophr. Res., 2010, 118(1-3), 140-145.
[http://dx.doi.org/10.1016/j.schres.2010.01.024] [PMID: 20171058]
[21]
Sass, L.; Parnas, J. Thought disorder, subjectivity, and the self. Schizophr. Bull., 2017, 43(3), 497-502.
[http://dx.doi.org/10.1093/schbul/sbx032]
[22]
Nordgaard, J.; Gravesen-Jensen, M.; Buch-Pedersen, M.; Parnas, J. Formal thought disorder and self-disorder: An empirical study. Front. Psychiatry, 2021, 12, 640921.
[http://dx.doi.org/10.3389/fpsyt.2021.640921] [PMID: 33897496]
[23]
Northoff, G. Resting state activity and the “stream of consciousness” in schizophrenia--neurophenomenal hypotheses. Schizophr. Bull., 2015, 41(1), 280-290.
[http://dx.doi.org/10.1093/schbul/sbu116] [PMID: 25150784]
[24]
Sass, L.; Pienkos, E. Beyond words: linguistic experience in melancholia, mania, and schizophrenia. Phenomenol. Cogn. Sci., 2015, 14(3), 475-495.
[http://dx.doi.org/10.1007/s11097-013-9340-0]
[25]
Moreau, J.J. Du hachisch et de l’aliénation mentale : Etudes psychologiques; Fortin, Masson and Co., 1845.
[26]
Paparelli, A.; Di Forti, M.; Morrison, P.D.; Murray, R.M. Drug-induced psychosis: How to avoid star gazing in schizophrenia research by looking at more obvious sources of light. Front. Behav. Neurosci., 2011, 5, 1.
[http://dx.doi.org/10.3389/fnbeh.2011.00001] [PMID: 21267359]
[27]
Gouzoulis-Mayfrank, E.; Habermeyer, E.; Hermle, L.; Steinmeyer, A.M.; Kunert, H.J.; Sass, H. Hallucinogenic drug induced states resemble acute endogenous psychoses: Results of an empirical study. Eur. Psychiatry, 1998, 13(8), 399-406.
[http://dx.doi.org/10.1016/S0924-9338(99)80686-5] [PMID: 19698655]
[28]
Vollenweider, F.X.; Kometer, M. The neurobiology of psychedelic drugs: Implications for the treatment of mood disorders. Nat. Rev. Neurosci., 2010, 11(9), 642-651.
[http://dx.doi.org/10.1038/nrn2884] [PMID: 20717121]
[29]
Abi-Saab, W.; D’Souza, D.; Moghaddam, B.; Krystal, J. The NMDA antagonist model for schizophrenia: Promise and pitfalls. Pharmacopsychiatry, 1998, 31(S2), 104-109.
[http://dx.doi.org/10.1055/s-2007-979354]
[30]
Adler, C.M.; Malhotra, A.K.; Elman, I.; Goldberg, T.; Egan, M.; Pickar, D.; Breier, A. Comparison of ketamine-induced thought disorder in healthy volunteers and thought disorder in schizophrenia. Am. J. Psychiatry, 1999, 156(10), 1646-1649.
[http://dx.doi.org/10.1176/ajp.156.10.1646] [PMID: 10518181]
[31]
Javitt, D.C.; Zukin, S.R. Recent advances in the phencyclidine model of schizophrenia. Am. J. Psychiatry, 1991, 148(10), 1301-1308.
[http://dx.doi.org/10.1176/ajp.148.10.1301] [PMID: 1654746]
[32]
Adler, C.; Goldberg, T.; Malhotra, A.; Pickar, D.; Breier, A. Effects of ketamine on thought disorder, working memory, and semantic memory in healthy volunteers. Biol. Psychiatry, 1998, 43(11), 811-816.
[http://dx.doi.org/10.1016/S0006-3223(97)00556-8] [PMID: 9611670]
[33]
Nagels, A.; Kirner-Veselinovic, A.; Krach, S.; Kircher, T. Neural correlates of S-ketamine induced psychosis during overt continuous verbal fluency. Neuroimage, 2011, 54(2), 1307-1314.
[http://dx.doi.org/10.1016/j.neuroimage.2010.08.021] [PMID: 20727411]
[34]
Nagels, A.; Cabanis, M.; Oppel, A.; Kirner-Veselinovic, A.; Schales, C.; Kircher, T. S-ketamine-induced nmda receptor blockade during natural speech production and its implications for formal thought disorder in schizophrenia: A pharmaco-fMRI study. Neuropsychopharmacology, 2018, 43(6), 1324-1333.
[http://dx.doi.org/10.1038/npp.2017.270] [PMID: 29105665]
[35]
Liang, L.; Silva, A.M.; Jeon, P.; Ford, S.D.; MacKinley, M.; Théberge, J.; Palaniyappan, L. Widespread cortical thinning, excessive glutamate and impaired linguistic functioning in schizophrenia: A cluster analytic approach. Front. Hum. Neurosci., 2022, 16, 954898.
[http://dx.doi.org/10.3389/fnhum.2022.954898] [PMID: 35992940]
[36]
Krystal, J.H.; Perry, E.B., Jr; Gueorguieva, R.; Belger, A.; Madonick, S.H.; Abi-Dargham, A.; Cooper, T.B.; MacDougall, L.; Abi-Saab, W.; D’Souza, D.C. Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: Implications for glutamatergic and dopaminergic model psychoses and cognitive function. Arch. Gen. Psychiatry, 2005, 62(9), 985-994.
[http://dx.doi.org/10.1001/archpsyc.62.9.985] [PMID: 16143730]
[37]
McKetin, R.; Dawe, S.; Burns, R.A.; Hides, L.; Kavanagh, D.J.; Teesson, M.; McD Young, R.; Voce, A.; Saunders, J.B. The profile of psychiatric symptoms exacerbated by methamphetamine use. Drug Alcohol Depend., 2016, 161, 104-109.
[http://dx.doi.org/10.1016/j.drugalcdep.2016.01.018] [PMID: 26874915]
[38]
Vernaleken, I.; Klomp, M.; Moeller, O.; Raptis, M.; Nagels, A.; Rösch, F.; Schaefer, W.M.; Cumming, P.; Gründer, G. Vulnerability to psychotogenic effects of ketamine is associated with elevated D2/3-receptor availability. Int. J. Neuropsychopharmacol., 2013, 16(4), 745-754.
[http://dx.doi.org/10.1017/S1461145712000764] [PMID: 22906553]
[39]
Andreou, C.; Veith, K.; Bozikas, V.P.; Lincoln, T.M.; Moritz, S. Effects of dopaminergic modulation on automatic semantic priming: A double-blind study. J. Psychiatry Neurosci., 2014, 39(2), 110-117.
[http://dx.doi.org/10.1503/jpn.130035] [PMID: 24099637]
[40]
Servan-Schreiber, D.; Cohen, J. Stroop task, language, and neuromodulation. In: Fundamentals of Neural Network Modeling; The MIT Press, 1998.
[http://dx.doi.org/10.7551/mitpress/3163.003.0014]
[41]
Spitzer, M. A cognitive neuroscience view of schizophrenic thought disorder. Schizophr. Bull., 1997, 23(1), 29-50.
[http://dx.doi.org/10.1093/schbul/23.1.29] [PMID: 9050111]
[42]
Goldberg, T.E.; Weinberger, D.R. Thought disorder in schizophrenia: A reappraisal of older formulations and an overview of some recent studies. Cogn. Neuropsychiatry, 2000, 5(1), 1-19.
[http://dx.doi.org/10.1080/135468000395790]
[43]
Bilder, R. M.; Lieberman, J. A.; Kim, Y.; Alvir, J. M. Methylphenidate and neuroleptic effects on oral word production in schizophrenia. Neuropsychiatry Neuropsychol. Behav. Neurol., 1992, 5, 262-271.
[44]
Salomé, F.; Boyer, P.; Fayol, M. The effects of psychoactive drugs and neuroleptics on language in normal subjects and schizophrenic patients: A review. Eur. Psychiatry, 2000, 15(8), 461-469.
[http://dx.doi.org/10.1016/S0924-9338(00)00520-4] [PMID: 11175923]
[45]
Abi-Dargham, A. Do we still believe in the dopamine hypothesis? New data bring new evidence. Int. J. Neuropsychopharmacol., 2004, 7(5)(Suppl. 1), S1-S5.
[http://dx.doi.org/10.1017/S1461145704004110] [PMID: 14972078]
[46]
De Gregorio, D.; Comai, S.; Posa, L.; Gobbi, G. d-Lysergic Acid Diethylamide (LSD) as a model of psychosis: Mechanism of action and pharmacology. Int. J. Mol. Sci., 2016, 17(11), 1953.
[http://dx.doi.org/10.3390/ijms17111953] [PMID: 27886063]
[47]
Gouzoulis-Mayfrank, E.; Heekeren, K.; Neukirch, A.; Stoll, M.; Stock, C.; Obradovic, M.; Kovar, K.A. Psychological effects of (S)-ketamine and N,N-dimethyltryptamine (DMT): A double-blind, cross-over study in healthy volunteers. Pharmacopsychiatry, 2005, 38(6), 301-311.
[http://dx.doi.org/10.1055/s-2005-916185] [PMID: 16342002]
[48]
Benes, F.M.; Vincent, S.L.; Marie, A.; Khan, Y. Up-regulation of GABAA receptor binding on neurons of the prefrontal cortex in schizophrenic subjects. Neuroscience, 1996, 75(4), 1021-1031.
[http://dx.doi.org/10.1016/0306-4522(96)00328-4] [PMID: 8938738]
[49]
Keverne, E.B. GABA-ergic neurons and the neurobiology of schizophrenia and other psychoses. Brain Res. Bull., 1999, 48(5), 467-473.
[http://dx.doi.org/10.1016/S0361-9230(99)00025-8] [PMID: 10372507]
[50]
Busatto, G.F.; Pilowsky, L.S.; Costa, D.C.; Ell, P.J.; David, A.S.; Lucey, J.V.; Kerwin, R.W. Correlation between reduced in vivo benzodiazepine receptor binding and severity of psychotic symptoms in schizophrenia. Am. J. Psychiatry, 1997, 154(1), 56-63.
[http://dx.doi.org/10.1176/ajp.154.1.56] [PMID: 8988959]
[51]
Coyle, J.T. NMDA receptor and schizophrenia: A brief history. Schizophr. Bull., 2012, 38(5), 920-926.
[http://dx.doi.org/10.1093/schbul/sbs076] [PMID: 22987850]
[52]
Kondziella, D.; Brenner, E.; Eyjolfsson, E.M.; Sonnewald, U. How do glial-neuronal interactions fit into current neurotransmitter hypotheses of schizophrenia? Neurochem. Int., 2007, 50(2), 291-301.
[http://dx.doi.org/10.1016/j.neuint.2006.09.006] [PMID: 17084946]
[53]
Mei, Y.Y.; Wu, D.C.; Zhou, N. Astrocytic regulation of glutamate transmission in schizophrenia. Front. Psychiatry, 2018, 9, 544.
[http://dx.doi.org/10.3389/fpsyt.2018.00544] [PMID: 30459650]
[54]
Mitterauer, B.J. Possible role of glia in cognitive impairment in schizophrenia. CNS Neurosci. Ther., 2011, 17(5), 333-344.
[http://dx.doi.org/10.1111/j.1755-5949.2009.00113.x] [PMID: 21951367]
[55]
Takahashi, N.; Sakurai, T.; Davis, K.L.; Buxbaum, J.D. Linking oligodendrocyte and myelin dysfunction to neurocircuitry abnormalities in schizophrenia. Prog. Neurobiol., 2011, 93(1), 13-24.
[http://dx.doi.org/10.1016/j.pneurobio.2010.09.004] [PMID: 20950668]
[56]
Mighdoll, M.I.; Tao, R.; Kleinman, J.E.; Hyde, T.M. Myelin, myelin-related disorders, and psychosis. Schizophr. Res., 2015, 161(1), 85-93.
[http://dx.doi.org/10.1016/j.schres.2014.09.040] [PMID: 25449713]
[57]
Mitterauer, B.J.; Kofler-Westergren, B. Possible effects of synaptic imbalances on oligodendrocyte-axonic interactions in schizophrenia: A hypothetical model. Front. Psychiatry, 2011, 2, 15.
[http://dx.doi.org/10.3389/fpsyt.2011.00015] [PMID: 21647404]
[58]
Satran, R. Dejerine-Sottas disease revisited. Arch. Neurol., 1980, 37(2), 67-68.
[http://dx.doi.org/10.1001/archneur.1980.00500510025002] [PMID: 7356409]
[59]
Nakao, T.; Takahashi, K.; Okuma, T.; Matsushima, Y.; Nagami, M. A case of Déjerine-Sottas disease with schizophrenic symptoms. A clinical and pathological study. Psychiatry Clin. Neurosci., 1975, 29(1), 13-24.
[http://dx.doi.org/10.1111/j.1440-1819.1975.tb02319.x] [PMID: 1158314]
[60]
Shepherd, A.M.; Laurens, K.R.; Matheson, S.L.; Carr, V.J.; Green, M.J. Systematic meta-review and quality assessment of the structural brain alterations in schizophrenia. Neurosci. Biobehav. Rev., 2012, 36(4), 1342-1356.
[http://dx.doi.org/10.1016/j.neubiorev.2011.12.015] [PMID: 22244985]
[61]
Fusar-Poli, P.; Radua, J.; McGuire, P.; Borgwardt, S. Neuroanatomical maps of psychosis onset: Voxel-wise meta-analysis of antipsychotic-naive VBM studies. Schizophr. Bull., 2012, 38(6), 1297-1307.
[http://dx.doi.org/10.1093/schbul/sbr134] [PMID: 22080494]
[62]
Hu, M.; Li, J.; Eyler, L.; Guo, X.; Wei, Q.; Tang, J.; Liu, F.; He, Z.; Li, L.; Jin, H.; Liu, Z.; Wang, J.; Liu, F.; Chen, H.; Zhao, J. Decreased left middle temporal gyrus volume in antipsychotic drug-naive, first-episode schizophrenia patients and their healthy unaffected siblings. Schizophr. Res., 2013, 144(1-3), 37-42.
[http://dx.doi.org/10.1016/j.schres.2012.12.018] [PMID: 23360727]
[63]
Sans-Sansa, B.; McKenna, P.J.; Canales-Rodríguez, E.J.; Ortiz-Gil, J.; López-Araquistain, L.; Sarró, S.; Dueñas, R.M.; Blanch, J.; Salvador, R.; Pomarol-Clotet, E. Association of formal thought disorder in schizophrenia with structural brain abnormalities in language-related cortical regions. Schizophr. Res., 2013, 146(1-3), 308-313.
[http://dx.doi.org/10.1016/j.schres.2013.02.032] [PMID: 23522907]
[64]
Ocklenburg, S.; Güntürkün, O. Hemispheric asymmetries: The comparative view. Front. Psychol., 2012, 3, 5.
[http://dx.doi.org/10.3389/fpsyg.2012.00005] [PMID: 22303295]
[65]
Ocklenburg, S.; Güntürkün, O.; Hugdahl, K.; Hirnstein, M. Laterality and mental disorders in the postgenomic age - A closer look at schizophrenia and language lateralization. Neurosci. Biobehav. Rev., 2015, 59, 100-110.
[http://dx.doi.org/10.1016/j.neubiorev.2015.08.019] [PMID: 26598216]
[66]
Sommer, I.; Aleman, A.; Ramsey, N.; Bouma, A.; Kahn, R. Handedness, language lateralisation and anatomical asymmetry in schizophrenia. Br. J. Psychiatry, 2001, 178(4), 344-351.
[http://dx.doi.org/10.1192/bjp.178.4.344] [PMID: 11282814]
[67]
Dragovic, M.; Hammond, G. Handedness in schizophrenia: A quantitative review of evidence. Acta Psychiatr. Scand., 2005, 111(6), 410-419.
[http://dx.doi.org/10.1111/j.1600-0447.2005.00519.x] [PMID: 15877707]
[68]
Sun, J.; Maller, J.J.; Guo, L.; Fitzgerald, P.B. Superior temporal gyrus volume change in schizophrenia: A review on Region of Interest volumetric studies. Brain Res. Brain Res. Rev., 2009, 61(1), 14-32.
[http://dx.doi.org/10.1016/j.brainresrev.2009.03.004] [PMID: 19348859]
[69]
Oertel-Knochel, V.; Knochel, C.; Stablein, M.; Linden, D.E.J. Abnormal functional and structural asymmetry as biomarker for schizophrenia. Curr. Top. Med. Chem., 2012, 12(21), 2434-2451.
[http://dx.doi.org/10.2174/156802612805289926] [PMID: 23279182]
[70]
Crow, T.J. Is schizophrenia the price that Homo sapiens pays for language? Schizophr. Res., 1997, 28(2-3), 127-141.
[http://dx.doi.org/10.1016/S0920-9964(97)00110-2] [PMID: 9468348]
[71]
Shenton, M.E.; Kikinis, R.; Jolesz, F.A.; Pollak, S.D.; LeMay, M.; Wible, C.G.; Hokama, H.; Martin, J.; Metcalf, D.; Coleman, M.; McCarley, R.W. Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. N. Engl. J. Med., 1992, 327(9), 604-612.
[http://dx.doi.org/10.1056/NEJM199208273270905] [PMID: 1640954]
[72]
Horn, H.; Federspiel, A.; Wirth, M.; Müller, T.J.; Wiest, R.; Wang, J.J.; Strik, W. Structural and metabolic changes in language areas linked to formal thought disorder. Br. J. Psychiatry, 2009, 194(2), 130-138.
[http://dx.doi.org/10.1192/bjp.bp.107.045633] [PMID: 19182174]
[73]
Horn, H.; Federspiel, A.; Wirth, M.; Müller, T.J.; Wiest, R.; Walther, S.; Strik, W. Gray matter volume differences specific to formal thought disorder in schizophrenia. Psychiatry Res. Neuroimaging, 2010, 182(2), 183-186.
[http://dx.doi.org/10.1016/j.pscychresns.2010.01.016] [PMID: 20418073]
[74]
Nakamura, M.; Nestor, P.G.; Levitt, J.J.; Cohen, A.S.; Kawashima, T.; Shenton, M.E.; McCarley, R.W. Orbitofrontal volume deficit in schizophrenia and thought disorder. Brain, 2007, 131(1), 180-195.
[http://dx.doi.org/10.1093/brain/awm265] [PMID: 18056163]
[75]
Sallet, P.C.; Elkis, H.; Alves, T.M.; Oliveira, J.R.; Sassi, E.; de Castro, C.C.; Busatto, G.F.; Gattaz, W.F. Reduced cortical folding in schizophrenia: An MRI morphometric study. Am. J. Psychiatry, 2003, 160(9), 1606-1613.
[http://dx.doi.org/10.1176/appi.ajp.160.9.1606] [PMID: 12944334]
[76]
Spalletta, G.; Spoletini, I.; Cherubini, A.; Rubino, I.A.; Siracusano, A.; Piras, F.; Caltagirone, C.; Marini, A. Cortico-subcortical underpinnings of narrative processing impairment in schizophrenia. Psychiatry Res. Neuroimaging, 2010, 182(1), 77-80.
[http://dx.doi.org/10.1016/j.pscychresns.2009.11.001] [PMID: 20189359]
[77]
Ballmaier, M.; Toga, A.W.; Siddarth, P.; Blanton, R.E.; Levitt, J.G.; Lee, M.; Caplan, R. Thought disorder and nucleus accumbens in childhood: A structural MRI study. Psychiatry Res. Neuroimaging, 2004, 130(1), 43-55.
[http://dx.doi.org/10.1016/j.pscychresns.2003.10.001] [PMID: 14972367]
[78]
Sandyk, R.; Kay, S.R.; Merriam, A.E. Atrophy of the cerebellar vermis: Relevance to the symptoms of schizophrenia. Int. J. Neurosci., 1991, 57(3-4), 205-212.
[http://dx.doi.org/10.3109/00207459109150694] [PMID: 1938163]
[79]
Arnedo, J.; Mamah, D.; Baranger, D.A.; Harms, M.P.; Barch, D.M.; Svrakic, D.M.; de Erausquin, G.A.; Cloninger, C.R.; Zwir, I. Decomposition of brain diffusion imaging data uncovers latent schizophrenias with distinct patterns of white matter anisotropy. Neuroimage, 2015, 120, 43-54.
[http://dx.doi.org/10.1016/j.neuroimage.2015.06.083] [PMID: 26151103]
[80]
Stein, F.; Buckenmayer, E.; Brosch, K.; Meller, T.; Schmitt, S.; Ringwald, K.G.; Pfarr, J.K.; Steinsträter, O.; Enneking, V.; Grotegerd, D.; Heindel, W.; Meinert, S.; Leehr, E.J.; Lemke, H.; Thiel, K.; Waltemate, L.; Winter, A.; Hahn, T.; Dannlowski, U.; Jansen, A.; Nenadić, I.; Krug, A.; Kircher, T. Dimensions of formal thought disorder and their relation to gray- and white matter brain structure in affective and psychotic disorders. Schizophr. Bull., 2022, 48(4), 902-911.
[http://dx.doi.org/10.1093/schbul/sbac002] [PMID: 35064667]
[81]
Griesinger, W. Die Pathologie und Therapie der psychischen Krankheiten, für Aerzte und Studirende; Krabbe, 1861.
[82]
Bopp, M.H.A.; Zöllner, R.; Jansen, A.; Dietsche, B.; Krug, A.; Kircher, T.T.J. White matter integrity and symptom dimensions of schizophrenia: A diffusion tensor imaging study. Schizophr. Res., 2017, 184, 59-68.
[http://dx.doi.org/10.1016/j.schres.2016.11.045] [PMID: 28012640]
[83]
Asami, T.; Saito, Y.; Whitford, T.J.; Makris, N.; Niznikiewicz, M.; McCarley, R.W.; Shenton, M.E.; Kubicki, M. Abnormalities of middle longitudinal fascicle and disorganization in patients with schizophrenia. Schizophr. Res., 2013, 143(2-3), 253-259.
[http://dx.doi.org/10.1016/j.schres.2012.11.030] [PMID: 23290607]
[84]
McGuire, P.; Quested, D.; Spence, S.; Murray, R.; Frith, C.; Liddle, P. Pathophysiology of ‘positive’ thought disorder in schizophrenia. Br. J. Psychiatry, 1998, 173(3), 231-235.
[http://dx.doi.org/10.1192/bjp.173.3.231] [PMID: 9926099]
[85]
Kircher, T.T.J.; Bulimore, E.T.; Brammer, M.J.; Williams, S.C.R.; Broome, M.R.; Murray, R.M.; McGuire, P.K. Differential activation of temporal cortex during sentence completion in schizophrenic patients with and without formal thought disorder. Schizophr. Res., 2001, 50(1-2), 27-40.
[http://dx.doi.org/10.1016/S0920-9964(00)00042-6] [PMID: 11378312]
[86]
Kircher, T. Neuronale Korrelate von Sprach- und Denkprozessen bei Gesunden und Patienten mit Schizophrenie; Steinkopff, 2003.
[87]
Kircher, T.; Liddle, P.; Brammer, M.; Murray, R.; McGuire, P. Neuronale korrelate “negativer” formaler denkstörungen. Nervenarzt, 2003, 74(9), 748-754.
[http://dx.doi.org/10.1007/s00115-003-1497-2] [PMID: 14504772]
[88]
Wensing, T.; Cieslik, E.C.; Müller, V.I.; Hoffstaedter, F.; Eickhoff, S.B.; Nickl-Jockschat, T. Neural correlates of formal thought disorder: An activation likelihood estimation meta-analysis. Hum. Brain Mapp., 2017, 38(10), 4946-4965.
[http://dx.doi.org/10.1002/hbm.23706] [PMID: 28653797]
[89]
Rapp, A.M.; Steinhäuser, A.E. Functional MRI of sentence-level language comprehension in schizophrenia: A coordinate-based analysis. Schizophr. Res., 2013, 150(1), 107-113.
[http://dx.doi.org/10.1016/j.schres.2013.07.019] [PMID: 23911258]
[90]
Sumner, P.J.; Bell, I.H.; Rossell, S.L. A systematic review of task-based functional neuroimaging studies investigating language, semantic and executive processes in thought disorder. Neurosci. Biobehav. Rev., 2018, 94, 59-75.
[http://dx.doi.org/10.1016/j.neubiorev.2018.08.005] [PMID: 30142368]
[91]
Horn, H.; Jann, K.; Federspiel, A.; Walther, S.; Wiest, R.; Müller, T.; Strik, W. Semantic network disconnection in formal thought disorder. Neuropsychobiology, 2012, 66(1), 14-23.
[http://dx.doi.org/10.1159/000337133] [PMID: 22797273]
[92]
Fuentes-Claramonte, P.; López-Araquistain, L.; Sarró, S.; Sans-Sansa, B.; Ortiz-Gil, J.; Maristany, T.; Salvador, R.; McKenna, P.J.; Pomarol-Clotet, E. Brain functional correlates of formal thought disorder in schizophrenia: Examining the frontal/dysexecutive hypothesis. Psychol. Med., 2021, 51(14), 2446-2453.
[http://dx.doi.org/10.1017/S0033291720001063] [PMID: 32338241]
[93]
Kircher, T.T.J.; Liddle, P.F.; Brammer, M.J.; Williams, S.C.R.; Murray, R.M.; McGUIRE, P.K. Reversed lateralization of temporal activation during speech production in thought disordered patients with schizophrenia. Psychol. Med., 2002, 32(3), 439-449.
[http://dx.doi.org/10.1017/S0033291702005287] [PMID: 11989989]
[94]
Stegmayer, K.; Stettler, M.; Strik, W.; Federspiel, A.; Wiest, R.; Bohlhalter, S.; Walther, S. Resting state perfusion in the language network is linked to formal thought disorder and poor functional outcome in schizophrenia. Acta Psychiatr. Scand., 2017, 136(5), 506-516.
[http://dx.doi.org/10.1111/acps.12790] [PMID: 28865406]
[95]
Chen, J.; Wensing, T.; Hoffstaedter, F.; Cieslik, E.C.; Müller, V.I.; Patil, K.R.; Aleman, A.; Derntl, B.; Gruber, O.; Jardri, R.; Kogler, L.; Sommer, I.E.; Eickhoff, S.B.; Nickl-Jockschat, T. Neurobiological substrates of the positive formal thought disorder in schizophrenia revealed by seed connectome-based predictive modeling. Neuroimage Clin., 2021, 30, 102666.
[http://dx.doi.org/10.1016/j.nicl.2021.102666] [PMID: 34215141]
[96]
Parnas, J.; Henriksen, M.G. Disordered self in the schizophrenia spectrum: A clinical and research perspective. Harv. Rev. Psychiatry, 2014, 22(5), 251-265.
[http://dx.doi.org/10.1097/HRP.0000000000000040] [PMID: 25126763]
[97]
Nordgaard, J.; Revsbech, R.; Henriksen, M.G. Self-disorders, neurocognition and rationality in schizophrenia: A preliminary study. Psychopathology, 2015, 48(5), 310-316.
[http://dx.doi.org/10.1159/000435892] [PMID: 26346129]
[98]
Haug, E.; Øie, M.; Melle, I.; Andreassen, O.A.; Raballo, A.; Bratlien, U.; Lien, L.; Møller, P. The association between self-disorders and neurocognitive dysfunction in schizophrenia. Schizophr. Res., 2012, 135(1-3), 79-83.
[http://dx.doi.org/10.1016/j.schres.2011.11.015] [PMID: 22137461]
[99]
Sandsten, K.E.; Wainio-Theberge, S.; Nordgaard, J.; Kjaer, T.W.; Northoff, G.; Parnas, J. Relating self-disorders to neurocognitive and psychopathological measures in first-episode schizophrenia. Early Interv. Psychiatry, 2022, 16(11), 1202-1210.
[http://dx.doi.org/10.1111/eip.13269] [PMID: 35081668]
[100]
Howes, O.D.; Shatalina, E. Integrating the neurodevelopmental and dopamine hypotheses of schizophrenia and the role of cortical excitation-inhibition balance. Biol. Psychiatry, 2022, 92(6), 501-513.
[http://dx.doi.org/10.1016/j.biopsych.2022.06.017] [PMID: 36008036]
[101]
Ziermans, T.; Swaab, H.; Stockmann, A.; de Bruin, E.; van Rijn, S. Formal thought disorder and executive functioning in children and adolescents with autism spectrum disorder: old leads and new avenues. J. Autism Dev. Disord., 2017, 47(6), 1756-1768.
[http://dx.doi.org/10.1007/s10803-017-3104-6] [PMID: 28342165]
[102]
Sass, L. Madness and Modernism: Insanity in the Light of Modern Art, Literature and Thought, 2nd ed.; Oxford University Press, 2017, pp. 94-95.

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