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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Review Article

Comprehensive Review on the Genus Haloxylon: Pharmacological and Phytochemical Properties

Author(s): Smail Amtaghri and Mohamed Eddouks*

Volume 24, Issue 10, 2024

Published on: 15 January, 2024

Page: [1146 - 1160] Pages: 15

DOI: 10.2174/0118715303270345231121112049

Price: $65

Abstract

Aims: This review aimed to review the biological, pharmacological, and phytochemical aspects of the genus Haloxylon.

Background: Plants of the genus Haloxylon have been used for a long time in traditional medicine, and they are distributed in the western Mediterranean region to the Middle East, Iran, Mongolia, Burma, and southwest China. The studied parts of Haloxylon species include aerial parts, leaves, branches, seeds, roots, rhizosphere, soil, and whole plants, used to treat several diseases, including sexual disorders, hepatobiliary disorders, eye disorders, skin diseases and hemorrhoids, diarrhea, and effective in the treatment of various ailments such as snake bite, stomach ache, diabetes, wounds, earache and sciatica pain, windbreak dune fixation, feeding of livestock and firewood.

Objectives: Till now, no review on the genus Haloxylon has been conducted. This review aimed to provide updated information on the genus Haloxylon, including traditional medicinal uses, valorization and exploitation of medicinal plants, phytochemistry, botanical characterization, pharmacological and toxicological research focusing on the medicinal properties of several Haloxylon species, especially their antioxidant, antibacterial, anti-inflammatory, cytotoxic and antifungal activities, as well as the effect of each bioactive molecule isolated from these species and their pharmacological use, including the preclinical evaluation of new drugs.

Materials and Methods: The present work was conducted using various scientific databases, including Science Direct, Scopus, PubMed, Google Scholar, etc. Correct plant names were verified from plantlist.org. The results of this search were interpreted, analyzed, and documented based on the obtained bibliographic information.

Results: Among all species of the Chenopodiaceae family, 6 species of the Haloxylon genus have approved antioxidant activity, 5 species have antibacterial activity, 3 species have anti-inflammatory activity, 2 species have cytotoxic activity, and 3 species have antifungal activity. The majority of the chemical constituents of this plant include flavonoids, alkaloids, phenols, saponins, glycosides, and tannins. Among them, the main bioactive constituents would be present in the alkaloid fraction. The study of more than 9 Haloxylon plants has identified more than 46 compounds. Pharmacological research proved that crude extracts and some pure compounds obtained from Haloxylon had activities for the treatment of different diseases. The objective of the present study was focused on antioxidant, antibacterial, anti-inflammatory, cytotoxic and antifungal diseases. From the study of the phytochemistry of the Haloxylon family, it was concluded that all studied plants had active compounds. Among them, 11 isolated molecules have medicinal activities with antioxidant properties, 10 molecules showed antibacterial effects, more than 6 molecules have anti-inflammatory properties, more than 9 isolated molecules have medicinal activities against cytotoxic diseases, and more than 28 molecules have antifungal effects. Therefore, the safety of Haloxylon herbal medicine should be considered a top priority in the early stages of development and clinical trials.

Conclusion: Several previously conducted studies have validated multiple traditional uses of Haloxylon species. Further research is needed on Haloxylon plants before they can be fully utilized in the clinic as a potent drug candidate, as researchers are mainly focusing on alkaloids, diterpenoids, and triterpenoids, whereas there are many other types of compounds that may possess novel biological activities.

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[1]
Rathore, V.S.; Singh, J.P.; Roy, M.M. Haloxylon stocksii (Boiss.) Benth. et Hook. f., a promising halophyte: Distribution, cultivation and utilization. Genet. Resour. Crop Evol., 2012, 59(6), 1213-1221.
[http://dx.doi.org/10.1007/s10722-012-9843-5]
[2]
Qasim, M.; Gulzar, S.; Shinwari, Z.K.; Aziz, I.; Khan, M.A. Traditional ethnobotanical uses of halophytes from Hub, Balochistan. Pak. J. Bot., 2010, 42(3), 1543-1551.
[3]
Ahmed, E.; Malik, A.; Riaz, N.; Sharif, A. Phytochemical studies of Haloxylon recurvum. J. Chem. Soc. Pak., 2004, 26, 389-391.
[4]
Akhtar, M.F.; Saleem, A. Alamgeer; Saleem, M. A Comprehensive review on ethnomedicinal, pharmacological and phytochemical basis of anticancer medicinal plants of pakistan. Curr. Cancer Drug Targets, 2019, 19(2), 120-151.
[http://dx.doi.org/10.2174/1568009618666180706164536] [PMID: 29984657]
[5]
Saleem, A.; Saleem, M.; Akhtar, M.F.; Shahzad, M.; Jahan, S. Moringa rivae leaf extracts attenuate Complete Freund’s adjuvant-induced arthritis in Wistar rats via modulation of inflammatory and oxidative stress biomarkers. Inflammopharmacology, 2020, 28(1), 139-151.
[http://dx.doi.org/10.1007/s10787-019-00596-3] [PMID: 31037575]
[6]
Baber, A.; Ahamd, S.; Rehman, T. A review on phytochemical analysis and ethnobotanical uses of Haloxylon stocksii. RADS J. Pharm. Pharm. Sci., 2018, 6(2), 162-167.
[7]
Dong, W.; Xu, C.; Li, D.; Jin, X.; Li, R.; Lu, Q.; Suo, Z. Comparative analysis of the complete chloroplast genome sequences in psammophytic Haloxylon species (Amaranthaceae). PeerJ, 2016, 4, e2699.
[http://dx.doi.org/10.7717/peerj.2699] [PMID: 27867769]
[8]
Boulos, L. Flora of Egypt; Al Hadara Publishing: Cairo, Egypt, 1999, p. 123.
[9]
Ahmad, M. Qualitative and quantitative determination of phytochemicals in Convolvulus leiocalycinus and Haloxylon griffithii. Pure Appl. Biol., 2019, 8(1), 733-741.
[http://dx.doi.org/10.19045/bspab.2019.80015]
[10]
Kamal, S.; Bibi, I.; Rehman, K.; Zahoor, A.F.; Kamal, A.; Aslam, F.; Alasmary, F.A.; Almutairi, T.M.; Alhajri, H.M.; Alissa, S.A.; Iqbal, H.M.N. Biological activities of in-house developed Haloxylon griffithii plant extract formulations. Plants, 2021, 10(7), 1427.
[http://dx.doi.org/10.3390/plants10071427] [PMID: 34371630]
[11]
Soliman, G.A.; Donia, A.E.R.M.; Awaad, A.S.; Alqasoumi, S.I.; Yusufoglu, H. Effect of Emex spinosa, Leptadenia pyrotechnica, Haloxylon salicornicum and Ochradenus baccatus extracts on the reproductive organs of adult male rats. Pharm. Biol., 2012, 50(1), 105-112.
[http://dx.doi.org/10.3109/13880209.2011.601465] [PMID: 22196585]
[12]
Ferheen, S.; Ahmed, E.; Afza, N.; Malik, A.; Shah, M.R.; Nawaz, S.A.; Choudhary, M.I. Haloxylines A and B, antifungal and cholinesterase inhibiting piperidine alkaloids from Haloxylon salicornicum. Chem. Pharm. Bull. (Tokyo), 2005, 53(5), 570-572.
[http://dx.doi.org/10.1248/cpb.53.570] [PMID: 15863932]
[13]
Peerzada, S.; Khan, M.T.; Akhtar, M.F.; Saleem, A.; Hamid, I.; Sharif, A.; Akhtar, B.; Ali, S.; Ahmed, S.; Raza, M. Phytochemical, anti-inflammatory, anti-nociceptive and cytotoxic basis for the use of Haloxylon stocksii. Pak. J. Pharm. Sci., 2020, 33(2)(Suppl.), 887-894.
[PMID: 32863266]
[14]
Eddouks, M.; Ajebli, M.; Hebi, M. Ethnopharmacological survey of medicinal plants used in Daraa-Tafilalet region (Province of Errachidia), Morocco. J. Ethnopharmacol., 2017, 198, 516-530.
[http://dx.doi.org/10.1016/j.jep.2016.12.017] [PMID: 28003130]
[15]
Elachouri, M. Ethnobotany/Ethnopharmacology, and bioprospecting: Issues on knowledge and uses of medicinal plants by Moroccan people. In: In natural products and drug discovery; Elsevier: Amsterdam, 2018; pp. 105-118.
[16]
Fakchich, J.; Elachouri, M. An overview on ethnobotanico-pharmacological studies carried out in Morocco, from 1991 to 2015: Systematic review (part 1). J. Ethnopharmacol., 2021, 267, 113200.
[http://dx.doi.org/10.1016/j.jep.2020.113200] [PMID: 32750461]
[17]
Jamila, F.; Mostafa, E. Ethnobotanical survey of medicinal plants used by people in Oriental Morocco to manage various ailments. J. Ethnopharmacol., 2014, 154(1), 76-87.
[http://dx.doi.org/10.1016/j.jep.2014.03.016] [PMID: 24685583]
[18]
Benkrief, R.; Brum-Bousquet, M.; Tillequin, F.; Koch, M. Alcaloïdes et flavonoïde des parties aériennes de Hammada articulata ssp. scoparia. Ann. Pharm. Fr., 1990, 48(4), 219-224.
[PMID: 2080838]
[19]
Mabberley, D.J. The plant-book: A portable dictionary of the vascular plants; Cambridge university press: Cambridge, England, 1997.
[20]
Roshier, D.A.; Böer, B.B.; Osborne, P.E. Vegetation of Abu Dhabi and a preliminary classification of its plant associations. Desert Ecology of Abu Dhabi; Pisces Publications, 1996, pp. 50-65.
[21]
Böer, B.; Sargeant, D. Desert perennials as plant and soil indicators in Eastern Arabia. Plant Soil, 1998, 199(2), 261-266.
[http://dx.doi.org/10.1023/A:1004318610230]
[22]
El-Wahab, R.H.; Al-Rashed, A.R.; Al-Hamad, Y. Conservation condition of Haloxylon salicornicum (Moq.) Bunge ex Boiss. in degraded desert habitats of northern Kuwait. Int. J. Curr. Microbiol. Appl. Sci., 2014, 3(10), 310-325.
[23]
Zaman, S.; Padmesh, S.; Bhat, N.R.; Tawfiq, H. Germination of some Kuwait’s native plants under saline conditions. Am.-Eurasian J. Agric. Environ. Sci., 2006, 1(2), 146-148.
[24]
Jafri, S.M.H. The flora of Karachi; The Book Corporation of Karachi: Khi, Pakistan, 1966.
[25]
Sastri, B.N. The Wealth of India: Council of Scientific and Industrial Research; New Delhi, 1, 1962.
[26]
Lamchouri, F.; Benali, T.; Bennani, B.; Toufik, H.; Hassani, L.I.M.; Bouachrine, B.; Lyoussi, B. Preliminary phytochemical and antimicrobial investigations of extracts of Haloxylon scoparium. J. Mater. Environ. Sci., 2012, 3, 754-759.
[27]
Zou, T.; Li, Y.; Xu, H.; Xu, G.Q. Responses to precipitation treatment for Haloxylon ammodendron growing on contrasting textured soils. Ecol. Res., 2010, 25(1), 185-194.
[http://dx.doi.org/10.1007/s11284-009-0642-1]
[28]
Butnik, A.A. Ecological anatomy of desert plants of middle asia. Trees, Shrubs, Semi-shrubs, 1991, 1, 266.
[29]
Mandaville, J.P. Plant life in the Rub’ al-Khali (the Empty Quarter), south-central Arabia. Proc. R. Soc. Edinb. Biol. Sci., 1986, 89, 147-157.
[http://dx.doi.org/10.1017/S0269727000008988]
[30]
Zohary, M. Geobotanical foundations of the middle east; Fischer, 1973.
[31]
Zaman, S. Effects of rainfall and grazing on vegetation yield and cover of two arid rangelands in Kuwait. Environ. Conserv., 1997, 24(4), 344-350.
[http://dx.doi.org/10.1017/S0376892997000453]
[32]
Kostecki, P. Assessments and remediation of oil contaminated soils; Taylor & Francis, 1999.
[33]
Hussain, S.; Ahmed, E.; Malik, A.; Jabbar, A.; Ashraf, M.; Lodhi, M.A.; Choudhary, M.I. Halosterols A and B, chymotrypsin inhibitory sterols from Haloxylon recurvum. Chem. Pharm. Bull. (Tokyo), 2006, 54(5), 623-625.
[http://dx.doi.org/10.1248/cpb.54.623] [PMID: 16651755]
[34]
Ahmad, H.; Bhatti, G.R.; Latif, A. Medicinal flora of the Thar Desert: An overview of problems and their feasible solutions. Zonas Áridas, 2006, 8(1), 73-84.
[35]
Khan, M.A.; Qaiser, M. Halophytes of Pakistan: Characteristics, distribution and potential economic usages.Sabkha ecosystems; Springer: Dordrecht, 2006, pp. 129-153.
[36]
Zohary, M.; Feinbrun-Dothan, N. Flora Palaestina, part 1; Israel Academy of Sciences and Humanities: Jerusalem, 1966, p. 76.
[37]
Tackholm, V.; Boulos, L. Students’ flora of Egypt; Brused Books: USA, 1974.
[38]
El-Shazly, A.; Wink, M. Tetrahydroisoquinoline and beta-carboline alkaloids from Haloxylon articulatum (Cav.) Bunge (Chenopodiaceae). Z. Naturforsch. C J. Biosci., 2003, 58(7-8), 477-480.
[http://dx.doi.org/10.1515/znc-2003-7-805] [PMID: 12939030]
[39]
Li, Y.; Plitzko, I.; Zaugg, J.; Hering, S.; Hamburger, M. HPLC-based activity profiling for GABA(A) receptor modulators: A new dihydroisocoumarin from Haloxylon scoparium. J. Nat. Prod., 2010, 73(4), 768-770.
[http://dx.doi.org/10.1021/np900803w] [PMID: 20210326]
[40]
Kurup, S.S.; Thayale Purayil, F.; Alkhaili, M.M.S.; Tawfik, N.H.; Cheruth, A.J.; Kabshawi, M.; Subramaniam, S. Thidiazuron (TDZ) induced organogenesis and clonal fidelity studies in Haloxylon persicum (Bunge ex Boiss & Buhse): An endangered desert tree species. Physiol. Mol. Biol. Plants, 2018, 24(4), 683-692.
[http://dx.doi.org/10.1007/s12298-018-0532-5] [PMID: 30042622]
[41]
Song, J.; Feng, G.; Tian, C.; Zhang, F. Strategies for adaptation of Suaeda physophora, Haloxylon ammodendron and Haloxylon persicum to a saline environment during seed-germination stage. Ann. Bot. (Lond.), 2005, 96(3), 399-405.
[http://dx.doi.org/10.1093/aob/mci196] [PMID: 16002418]
[42]
Ruan, X.; Wang, Q.; Chen, Y.; Huang, J. Physio-ecological response of Haloxylon persicum photosynthetic shoots to drought stress. Front. For. China, 2006, 1(2), 176-181.
[http://dx.doi.org/10.1007/s11461-006-0021-9]
[43]
Ehsen, S.; Qasim, M.; Abideen, Z.; Rizvi, R.F.; Gul, B.; Ansari, R.; Khan, M.A. Secondary metabolites as anti-nutritional factors in locally used halophytic forage/fodder. Pak. J. Bot., 2016, 48(2), 629-636.
[44]
Bellakhdar, J. La pharmacopée traditionnelle marocaine; Le Fennec & Ibis press: France, 1997.
[45]
Cragg, G.M.; Boyd, M.R.; Khanna, R.; Newman, D.J.; Sausville, E.A. Natural product drug discovery and development. In: Phytochemicals in Human Health Protection, Nutrition, and Plant Defense; Springer: Berlin, Heidelberg, 1999; pp. 1-29.
[46]
Bourogaa, E.; Bertrand, J.; Despeaux, M.; Jarraya, R.; Fabre, N.; Payrastre, L.; Demur, C.; Fournié, J.J.; Damak, M.; Feki, A.E.; Racaud-Sultan, C. Hammada scoparia flavonoids and rutin kill adherent and chemoresistant leukemic cells. Leuk. Res., 2011, 35(8), 1093-1101.
[http://dx.doi.org/10.1016/j.leukres.2010.12.011] [PMID: 21216465]
[47]
Awaad, A.S.; Zain, M.E.; Al Othman, M.R.; Al-Dosary, S.K. Phytochemical analysis and antimicrobial activity of medicinal plants against pathogenic microorganisms. Life Sci., 2014, 11(7)
[48]
El-Shazly, A.M.; Dora, G.; Wink, M. Alkaloids of Haloxylon salicornicum (Moq.) Bunge ex Boiss. (Chenopodiaceae). Pharmazie, 2005, 60(12), 949-952.
[PMID: 16398274]
[49]
Ashraf, M.A.; Mahmood, K.; Wajid, A.; Qureshi, A.K.; Gharibreza, M. Chemical constituents of Haloxylon salicornicum plant from Cholistan desert, Bahawalpur, Pakistan. J. Food Agric. Environ., 2013, 11(3-4), 1176-1182.
[50]
Ullah, R.; Alsaid, M.S.; Alqahtani, A.S.; Shahat, A.A.; Naser, A.A.; Mahmood, H.M.; Ahamad, S.R.; Al-Mishari, A.A.; Ahmad, S. Anti-inflammatory, antipyretic, analgesic, and antioxidant activities of Haloxylon salicornicum aqueous fraction. Open Chem., 2019, 17(1), 1034-1042.
[http://dx.doi.org/10.1515/chem-2019-0113]
[51]
Kaur, P.; Bains, N.S. Extraction of flavonoids from in vivo and in vitro tissue culture of some important halophyes of western Rajasthan. Int. J. Pharm. Tech. Res., 2012, 4(3), 1167-1171.
[52]
Singh, J.P.; Rathore, V.S.; Roy, M.M. Notes about Haloxylon salicornicum (Moq.) Bunge ex Boiss., a promising shrub for arid regions. Genet. Resour. Crop Evol., 2015, 62(3), 451-463.
[http://dx.doi.org/10.1007/s10722-014-0212-4]
[53]
Bouaziz, A.; Mhalla, D.; Zouari, I.; Jlaiel, L.; Tounsi, S.; Jarraya, R.; Trigui, M. Antibacterial and antioxidant activities of Hammada scoparia extracts and its major purified alkaloids. S. Afr. J. Bot., 2016, 105, 89-96.
[http://dx.doi.org/10.1016/j.sajb.2016.03.012]
[54]
Azhar, M.F.; Aziz, A.; Haider, M.S.; Nawaz, M.F.; Zulfiqar, M.A. Exploring the ethnobotany of Haloxylon recurvum (Khar) and Haloxylon salicornicum (Lana) in Cholistan desert, Pakistan. Pak. J. Agric. Sci., 2015, 52(4), 1085-1090.
[55]
Ahmad, M.; Eram, S. Hepatoprotective studies on Haloxylon Salicornicum: A plant from Cholistan desert. Pak. J. Pharm. Sci., 2011, 24(3), 377-382.
[PMID: 21715272]
[56]
Kharchoufa, L.; Bouhrim, M.; Bencheikh, N.; El Assri, S.; Amirou, A.; Yamani, A.; Choukri, M.; Mekhfi, H.; Elachouri, M. Acute and subacute toxicity studies of the aqueous extract from Haloxylon scoparium pomel (Hammada scoparia (Pomel)) by oral administration in rodents. BioMed Res. Int., 2020, 2020, 1-11.
[http://dx.doi.org/10.1155/2020/4020647] [PMID: 33123573]
[57]
Wang, F.; Zhuo, B.; Wang, S.; Lou, J.; Zhang, Y.; Chen, Q.; Shi, Z.; Song, Y.; Tu, P. Atriplex canescens: A new host for Cistanche deserticola. Heliyon, 2021, 7(6), e07368.
[http://dx.doi.org/10.1016/j.heliyon.2021.e07368] [PMID: 34235285]
[58]
Zehra, A.; Saeed, R. Germination response of potential halophyte Haloxylon stocksii in different salts and photoperiods. FUUAST J. Bio., 2015, 5(1), 99-105.
[59]
Agati, G.; Azzarello, E.; Pollastri, S.; Tattini, M. Flavonoids as antioxidants in plants: Location and functional significance. Plant Sci., 2012, 196, 67-76.
[http://dx.doi.org/10.1016/j.plantsci.2012.07.014] [PMID: 23017900]
[60]
Van Hung, P. Phenolic compounds of cereals and their antioxidant capacity. Crit. Rev. Food Sci. Nutr., 2016, 56(1), 25-35.
[http://dx.doi.org/10.1080/10408398.2012.708909] [PMID: 25075608]
[61]
Ghazanfar, S.A. Handbook of Arabian medicinal plants; CRC press, 1994.
[http://dx.doi.org/10.1201/b14834]
[62]
Al-Shawi, A.A.A.; Yousif, A.A.; Hameed, M. Antioxidant, antibacterial, and anticancer properties of Haloxylon salicornicum extracted by microwave-assisted extraction. Egyp. Pharm. J., 2021, 20(3), 225.
[http://dx.doi.org/10.4103/epj.epj_23_21]
[63]
Alshamsi, M.M.A.; Alnuaimi, A.K.H.; Alshamsi, R.M.S.; Senthilkumar, A.; Karthishwaran, K.; Al-Zayadneh, W.A.W.; Cheruth, A.J. Phytochemical analysis and antioxidant activity of Haloxylon salicarnicum, Ochradenus arabicus and Tamarix nilotica. J. Phytol., 2019, 11, 47-50.
[http://dx.doi.org/10.25081/jp.2019.v11.6149]
[64]
Alqasoumi, S.I.; Soliman, G.A.E.H.; Awaad, A.S.; Donia, A.E.R.M. Anti-inflammatory activity, safety and protective effects of Leptadenia pyrotechnica, Haloxylon salicornicum and Ochradenus baccatus in ulcerative colitis. Phytopharmacology, 2012, 2(1), 58-71.
[65]
Saeed, N.; Khan, M.R.; Shabbir, M. Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L. BMC Complement. Altern. Med., 2012, 12(1), 221.
[http://dx.doi.org/10.1186/1472-6882-12-221] [PMID: 23153304]
[66]
Messaouda, A.; Abdelkrim, C.; Elyacout, C.; Belkhir, D.; Nouredine, G. Comparative study of the antioxidant activity and phenols and flavonoids contents of the ethyl acetate extracts from two saharan chenopodacea. Algerian J. Arid. Environ., 2016, 6(1)
[67]
Bourogaa, E.; Nciri, R.; Mezghani-Jarraya, R.; Racaud-Sultan, C.; Damak, M.; El Feki, A. Antioxidant activity and hepatoprotective potential of Hammada scoparia against ethanol-induced liver injury in rats. J. Physiol. Biochem., 2013, 69(2), 227-237.
[http://dx.doi.org/10.1007/s13105-012-0206-7] [PMID: 22893526]
[68]
Wahab, A.; Ahmed, E.; Nawaz, S.A.; Sharif, A.; Haq, R.U.; Malik, A.; Choudhary, M.I.; Raza, M. A pharmacological and toxicological evaluation of Haloxylon recurvum. Nat. Prod. Res., 2008, 22(15), 1317-1326.
[http://dx.doi.org/10.1080/14786410701824882] [PMID: 19023788]
[69]
Lorke, D. A new approach to practical acute toxicity testing. Arch. Toxicol., 1983, 54(4), 275-287.
[http://dx.doi.org/10.1007/BF01234480] [PMID: 6667118]
[70]
Coughenour, L.L.; McLean, J.R.; Parker, R.B. A new device for the rapid measurement of impaired motor function in mice. Pharmacol. Biochem. Behav., 1977, 6(3), 351-353.
[http://dx.doi.org/10.1016/0091-3057(77)90036-3] [PMID: 857257]
[71]
Palmer, G.C.; Murray, R.J.; Cramer, C.L.; Stagnitto, M.L.; Knowles, M.K.; Freedman, L.R.; Eismann, M.S.; Mahmood, N.; Balestra, M.; Borrelli, A.R.; Hudzik, T.J.; McCarthy, D.J. [S]-AR-R 15896AR-A novel anticonvulsant: Acute safety, pharmacokinetic and pharmacodynamic properties. J. Pharmacol. Exp. Ther., 1999, 288(1), 121-132.
[PMID: 9862762]
[72]
Alam, E.A. Phytochemical screening on different plant parts of some succulent plants of Egypt. New York Sci. J., 2011, 4, 15-18.
[73]
Ajabnoor, M.A.; Al-Yahya, M.A.; Tariq, M.; Jayyab, A.A. Antidiabetic activity of Hammada salicornica. Fitoterapia, 1984, 55(2), 107-109.
[74]
Al-Shanwani, M. Plants used in Saudi folk medicine; King Abdul Aziz City for Science and Technology: Riyadh, 1996.
[75]
Raish, M.; Ahmad, A.; Alkharfy, K.M.; Ahamad, S.R.; Mohsin, K.; Al-Jenoobi, F.I.; Al-Mohizea, A.M.; Ansari, M.A. Hepatoprotective activity of Lepidium sativum seeds against D-galactosamine/lipopolysaccharide induced hepatotoxicity in animal model. BMC Complement. Altern. Med., 2016, 16(1), 501.
[http://dx.doi.org/10.1186/s12906-016-1483-4] [PMID: 27912738]
[76]
Ahmed, E.; Malik, A.; Afza, N.; Riaz, N.; Anis, I.; Sharif, A.; Farheen, S.; Lodhi, M.; Choudhary, M. Chymotrypsin inhibitory constituents from Haloxylon recurvum. Nat. Prod. Res., 2007, 21(1), 69-75.
[http://dx.doi.org/10.1080/14786410500160850] [PMID: 17365691]
[77]
Ahmed, E.; Nawaz, S.A.; Malik, A.; Choudhary, M.I. Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum. Bioorg. Med. Chem. Lett., 2006, 16(3), 573-580.
[http://dx.doi.org/10.1016/j.bmcl.2005.10.042] [PMID: 16274989]
[78]
Ghimire, B.K.; Ghimire, B.; Yu, C.Y.; Chung, I.M. Allelopathic and autotoxic effects of Medicago sativa-derived allelochemicals. Plants, 2019, 8(7), 233.
[http://dx.doi.org/10.3390/plants8070233] [PMID: 31323838]
[79]
Abdel-Farid, I.; El-Sayed, M.; Mohamed, E. Allelopathic potential of Calotropis procera and Morettia philaeana. Int. J. Agric. Biol., 2013, 15(1)
[80]
Abdel-Farid, I.B.; Massoud, M.S.; Al-Enazy, Y.; Abdel Latef, A.A.H.; Jahangir, M.; Gomaa, N.H. Allelopathic potential of Haloxylon persicum against wheat and black mustard with special reference to its phytochemical composition and antioxidant activity. Agronomy (Basel), 2021, 11(2), 244.
[http://dx.doi.org/10.3390/agronomy11020244]
[81]
Brass, C.; Shainhouse, J.Z.; Stevens, D.A. Variability of agar dilution-replicator method of yeast susceptibility testing. Antimicrob. Agents Chemother., 1979, 15(6), 763-768.
[http://dx.doi.org/10.1128/AAC.15.6.763] [PMID: 573098]
[82]
Tougu, V. Acetylcholinesterase: Mechanism of catalysis and inhibition. Curr. Med. Chem. Cent. Nerv. Syst. Agents, 2001, 1(2), 155-170.
[http://dx.doi.org/10.2174/1568015013358536]
[83]
Yu, Q.; Holloway, H.W.; Utsuki, T.; Brossi, A.; Greig, N.H. Synthesis of novel phenserine-based-selective inhibitors of butyrylcholinesterase for Alzheimer’s disease. J. Med. Chem., 1999, 42(10), 1855-1861.
[http://dx.doi.org/10.1021/jm980459s] [PMID: 10346939]
[84]
Ellman, G.L.; Courtney, K.D.; Andres, V., Jr; Featherstone, R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol., 1961, 7(2), 88-95.
[http://dx.doi.org/10.1016/0006-2952(61)90145-9] [PMID: 13726518]
[85]
Riaz, N.; Malik, A. Aziz-ur-Rehman; Nawaz, S.A.; Muhammad, P.; Choudhary, M.I. Cholinesterase-inhibiting withanolides fromAjuga bracteosa. Chem. Biodivers., 2004, 1(9), 1289-1295.
[http://dx.doi.org/10.1002/cbdv.200490091] [PMID: 17191906]
[86]
Bnouham, M.; Mekhfi, H.; Legssyer, A.; Ziyyat, A. Ethnopharmacology Forum Medicinal plants used in the treatment of diabetes in Morocco. Int. J. Diabetes Metab., 2002, 10(1), 33-50.
[87]
Eddouks, M.; Maghrani, M.; Lemhadri, A.; Ouahidi, M.L.; Jouad, H. Ethnopharmacological survey of medicinal plants used for the treatment of diabetes mellitus, hypertension and cardiac diseases in the south-east region of Morocco (Tafilalet). J. Ethnopharmacol., 2002, 82(2-3), 97-103.
[http://dx.doi.org/10.1016/S0378-8741(02)00164-2] [PMID: 12241983]
[88]
Bibi, N.; Tanoli, S.A.K.; Farheen, S.; Afza, N.; Siddiqi, S.; Zhang, Y.; Kazmi, S.U.; Malik, A. in vitro antituberculosis activities of the constituents isolated from Haloxylon salicornicum. Bioorg. Med. Chem. Lett., 2010, 20(14), 4173-4176.
[http://dx.doi.org/10.1016/j.bmcl.2010.05.061] [PMID: 20542692]
[89]
Ullah, R.; Alsaid, M.S.; Shahat, A.A.; Naser, A.A.; Al-Mishari, A.A.; Adnan, M.; Tariq, A. Antioxidant and hepatoprotective effects of methanolic extracts of Zilla spinosa and Hammada elegans against carbon tetrachlorideinduced hepatotoxicity in rats. Open Chem., 2018, 16(1), 133-140.
[http://dx.doi.org/10.1515/chem-2018-0021]
[90]
Choudhary, M.I. Azizuddin; Jalil, S.; Israr, M.; Attar-ur-Rahman, Inhibition of respiratory burst in human neutrophils and lipoxygenase enzyme by compounds from Haloxylon griffithii. Phytother. Res., 2006, 20(10), 840-843.
[http://dx.doi.org/10.1002/ptr.1914] [PMID: 16835879]
[91]
Sharif, A.; Ahmed, E.; Malik, A. Recurvosides A and B, antifungal novel steroidal glucosides from Haloxylon recurvum. Z. Naturforsch. B. J. Chem. Sci., 2006, 61(9), 1148-1152.
[http://dx.doi.org/10.1515/znb-2006-0915]
[92]
Ben Salah, H.; Jarraya, R.; Martin, M.T.; Veitch, N.C.; Grayer, R.J.; Simmonds, M.S.J.; Damak, M. Flavonol triglycosides from the leaves of Hammada scoparia (POMEL) ILJIN. Chem. Pharm. Bull. (Tokyo), 2002, 50(9), 1268-1270.
[http://dx.doi.org/10.1248/cpb.50.1268] [PMID: 12237550]
[93]
Chaouche, T.M.; Haddouchi, F.; Ksouri, R.; Atik-Bekkara, F. Evaluation of antioxidant activity of hydromethanolic extracts of some medicinal species from South Algeria. J. Chin. Med. Assoc., 2014, 77(6), 302-307.
[http://dx.doi.org/10.1016/j.jcma.2014.01.009] [PMID: 24613372]
[94]
Ebrahim, A.M.; Idris, A.M.; Alnajjar, A.O.; Michalke, B. Cr and Mn total, accessible species, and protein-fraction contents in plants used for traditional anti-diabetes treatment. J. Trace Elem. Med. Biol., 2020, 62, 126645.
[http://dx.doi.org/10.1016/j.jtemb.2020.126645] [PMID: 32937239]
[95]
Al-Saeed, A.H. Study the effect of some extracts of Haloxylon sp. on blood glucose level in normal and hyperglycemic rabbits induced by Alloxan. Diss. M. Sc. Thesis, College of Science- University of Basrah, 2002.
[96]
Yang, Y.F.; Zhou, H.F.; Xu, L.G. Dynamic variations of soil moisture in Haloxylon ammodendron root zone in Gurbantunggut Desert. Ying Yong Sheng Tai Xue Bao, 2011, 22(7), 1711-1716.
[PMID: 22007445]
[97]
Tobe, K.; Li, X.; Omasa, K. Effects of sodium chloride on seed germination and growth of two Chinese desert shrubs, Haloxylon ammodendron and H. persicum (Chenopodiaceae). Aust. J. Bot., 2000, 48(4), 455-460.
[http://dx.doi.org/10.1071/BT99013]
[98]
Arabzadeh, N. A study on the impact of drought stress on changes of free proline in two species of Haloxylon persicum and Haloxylon aphyllum. J. Plant Sci., 2011, 6(5), 190-201.
[http://dx.doi.org/10.3923/jps.2011.190.201]
[99]
Arabzadeh, N. The effect of drought stress on soluble carbohydrates (sugars) in two species of Haloxylon persicum and Haloxylon aphyllum. Asian J. Plant Sci., 2011, 11(1), 44-51.
[http://dx.doi.org/10.3923/ajps.2012.44.51]
[100]
Arabzadeh, N.; Khavari-Ne, R.A. Effect of drought stress on superoxide dismutase activity in two species of Haloxylon aphyllum and Haloxylon persicum. Pak. J. Biol. Sci., 2013, 16(8), 351-361.
[http://dx.doi.org/10.3923/pjbs.2013.351.361] [PMID: 24494516]
[101]
Hameed, M.; Ashraf, M.; Al-Quriany, F.; Nawaz, T.; Ahmad, M.S.A.; Younis, A.; Naz, N. Medicinal flora of the Cholistan desert: A review. Pak. J. Bot., 2011, 43(2), 39-50.
[102]
Boukef, M.K. Les plantes dans la médecine traditionnelle tunisienne, agence de coopération culturelle et technique; Société Française d'Ethnopharmacologie: Paris, France, 1986.
[103]
Taïr, K.; Kharoubi, O.; Taïr, O.A.; Hellal, N.; Benyettou, I.; Aoues, A. Aluminium-induced acute neurotoxicity in rats: Treatment with aqueous extract of Arthrophytum (Hammada scoparia). J. Acute Dis., 2016, 5(6), 470-482.
[http://dx.doi.org/10.1016/j.joad.2016.08.028]
[104]
Sathiyamoorthy, P.; Lugasi-Evgi, H.; Van-Damme, P.; Abu-Rabia, A.; Gopas, J.; Golan-Goldhirsh, A. Larvicidal activity in desert plants of the Negev and Bedouin market plant products. Intern. J. Pharmacog., 1997, 35(4), 265-273.
[http://dx.doi.org/10.1076/phbi.35.4.265.13314]
[105]
Sathiyamoorthy, P.; Lugasi-Evgi, H.; Schlesinger, P.; Kedar, I.; Gopas, J.; Pollack, Y.; Golan-Goldhirsh, A. Screening for cytotoxic and antimalarial activities in desert plants of the Negev and Bedouin market plant products. Pharm. Biol., 1999, 37(3), 188-195.
[http://dx.doi.org/10.1076/phbi.37.3.188.6298]
[106]
Mezghani-Jarraya, R.; Hammami, H.; Ayadi, A.; Damak, M. Molluscicidal activity of Hammada scoparia (Pomel) Iljin leaf extracts and the principal alkaloids isolated from them against Galba truncatula. Mem. Inst. Oswaldo Cruz, 2009, 104(7), 1035-1038.
[http://dx.doi.org/10.1590/S0074-02762009000700017] [PMID: 20027474]
[107]
Ramadan, S.A.; Kamel, E.M.; Ewais, M.A.; Khowailed, A.A.; Hassanein, E.H.M.; Mahmoud, A.M. Flavonoids of Haloxylon salicornicum (Rimth) prevent cisplatin-induced acute kidney injury by modulating oxidative stress, inflammation, Nrf2, and SIRT1. Environ. Sci. Pollut. Res. Int., 2023, 30(17), 49197-49214.
[http://dx.doi.org/10.1007/s11356-023-25694-2] [PMID: 36773264]
[108]
Eddouks, M.; Amtaghri, S. Study of the Antihypertensive and vasorelaxant activities of Haloxylon scoparium in rats. Cardiovasc. Hematol. Agents Med. Chem., 2023, 21(2), 139-153.
[http://dx.doi.org/10.2174/1871525720666220823163542] [PMID: 36017835]
[109]
Yang, F.; Lv, G.; Qie, Y. Hydraulic characteristics and carbon metabolism of Haloxylon ammodendron under different water–salt content. AoB Plants, 2022, 14(5), plac042.
[http://dx.doi.org/10.1093/aobpla/plac042] [PMID: 36285192]
[110]
Zhou, D.; Si, J.; He, X.; Jia, B.; Zhao, C.; Wang, C.; Qin, J.; Zhu, X.; Wang, C.; Qin, J.; Zhu, X. The Process of Soil Desiccation under Haloxylon ammodendron Plantations: A Case Study of the Alxa Legue Desert, China. Plants, 2022, 11(3), 235.
[http://dx.doi.org/10.3390/plants11030235] [PMID: 35161216]
[111]
Dang, H.; Zhao, W.; Zhang, T.; Cheng, Y.; Dong, J.; Zhuang, L. Great gerbil burrowing-induced microbial diversity shapes the rhizosphere soil microenvironments of Haloxylon ammodendron in temperate deserts. Front. Microbiol., 2022, 13, 960594.
[http://dx.doi.org/10.3389/fmicb.2022.960594] [PMID: 36051766]
[112]
Yang, F.; Lv, G. Metabolomic Analysis of the Response of Haloxylon ammodendron and Haloxylon persicum to Drought. Int. J. Mol. Sci., 2023, 24(10), 9099.
[http://dx.doi.org/10.3390/ijms24109099] [PMID: 37240446]
[113]
Najafi Zilaie, M.; Mosleh Arani, A.; Etesami, H.; Dinarvand, M. Improved salinity and dust stress tolerance in the desert halophyte Haloxylon aphyllum by halotolerant plant growth-promoting rhizobacteria. Front. Plant Sci., 2022, 13, 948260.
[http://dx.doi.org/10.3389/fpls.2022.948260] [PMID: 35991408]

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