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ISSN (Online): 2666-8637

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Clinical Trial

Effects of Probiotics and Magnesium Co-supplementation on Stress Levels and Quality of Life in Obese Patients with Depressed Mood: A Randomized, Double-Blinded Placebo-Controlled Clinical Trial

In Press, (this is not the final "Version of Record"). Available online 22 October, 2023
Author(s): Marzieh Ghasvarian, Sepideh Mahboobi, Reza Sadeghi, Haleh Ghaem, Arvin Hedayati, Shohre Alipour, Neda Valisoltani, Asma Rajabi Harsini and Mohammad Hassan Eftekhari*
Published on: 22 October, 2023

Article ID: e221023222518

DOI: 10.2174/0126668629257875230920091340

Price: $95

Abstract

Background and objectives: Obesity is strongly associated with mood disorders. There is evidence that obesity and mood disorders may be related pathologically. Depression and manic episodes are more common among overweight or obese individuals. Human subjects have reported the restorative effects of probiotic supplementation on neuroendocrine functions. Gut microbiota, neuroendocrine status, and obesity are related. Magnesium enriches the gut microbiota. Based on the association between gut microbiota, magnesium levels, obesity, and neuropsychiatric disorders, we examined the possibility of co-supplementation of probiotics and magnesium in humans.

Methods: For 74 individuals, demographic data, quality of life scores (SF -12), depression, anxiety, and stress scores (DASS-21) were collected, along with body mass index (BMI), waist circumfer-ence, and serum cortisol levels. An SPSS analysis was performed.

Results: Both the intervention and control groups experienced significant reductions in depression, anxiety, and stress. A significant improvement in mental health, role-emotional function, and vital-ity was observed in the probiotic and magnesium supplement group.

Conclusion: Magnesium supplements and probiotics increased vitality (VT) and mental health (MH) and reduced functional impairment from emotional stress (RE). They experienced fewer functional limitations because of physical conditions.

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