Login Register Cart 0
Generic placeholder image

Current Functional Foods

Editor-in-Chief

ISSN (Print): 2666-8629
ISSN (Online): 2666-8637

Back
Journal Home About Journal Editorial Board Current Issue Volumes/Issues
Subscribe
Research Article

In-vitro Antioxidant and Antimicrobial Effects of Mimusops elengi (Linn.) Stem Bark Extract

In Press, (this is not the final "Version of Record"). Available online 18 October, 2023
Author(s): Maneesh Mohan, Anayat Ullah Mir, Nadeem Khan, Thakur Gurjeet Singh and Manish Kumar*
Published on: 18 October, 2023

Article ID: e181023222315

DOI: 10.2174/0126668629265151231005050302

Price: $95

Abstract

Background: Mimusops elengi (Linn.) has high medicinal value and is a native plant of India. In the traditional system of medicine, the bark of M. elengi was used as cardiotonic, alexipharmic, stomachic, anthelmintic, tonic, and tooth-protectant that might be associated with antioxidant and antimicrobial effects. Microorganisms are an integral part of our buccal cavity and intestines, however, a change in normal microflora can result in pathological manifestations.

Objective: The current study attempts to evaluate the antioxidant activity of M. elengi (Linn.) stem bark extracts using in-vitro methods and the efficacy of M. elengi (Linn.) stem bark extracts against Gram-negative bacteria and fungal strains.

Methods: Extracts (aqueous and ethanolic) were prepared using a Soxhlet assembly and rotavapor. The extracts were subjected to phytochemical screening and in-vitro antioxidant and antimicrobial tests.

Results: The ethanolic and aqueous extracts of M. elengi stem bark showed appreciable DPPH free radical scavenging, reducing power, and nitric oxide inhibitory activities with a concentration-dependent increase in their effects. The ethanolic extract showed better antioxidant activity relative to the aqueous extract. Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, and Salmonella typhi growth were suppressed by the M. elengi extracts. Both extracts showed maximum activity against S. typhi, while the ethanolic extract had better antibacterial and antifungal (S. cerevisiae, P. chrysogenum, and A. fumigatus) activity relative to the aqueous extract.

Conclusions: The findings of the present study conclude that aqueous and ethanolic extracts of M. elengi (L.) stem bark showed potent antioxidant and antimicrobial activity.

[1]
Larsson DGJ, Flach CF. Antibiotic resistance in the environment. Nat Rev Microbiol 2022; 20(5): 257-69.
[http://dx.doi.org/10.1038/s41579-021-00649-x] [PMID: 34737424]
[2]
Huemer M, Mairpady Shambat S, Brugger SD, Zinkernagel AS. Antibiotic resistance and persistence-Implications for human health and treatment perspectives. EMBO Rep 2020; 21(12): e51034.
[http://dx.doi.org/10.15252/embr.202051034] [PMID: 33400359]
[3]
Salmerón-Manzano E, Garrido-Cardenas JA, Manzano-Agugliaro F. Worldwide research trends on medicinal plants. Int J Environ Res Public Health 2020; 17(10): 3376.
[http://dx.doi.org/10.3390/ijerph17103376] [PMID: 32408690]
[4]
Prasathkumar M, Anisha S, Dhrisya C, Becky R, Sadhasivam S. Therapeutic and pharmacological efficacy of selective Indian medicinal plants - A review. Phytomedicine Plus 2021; 1(2): 100029.
[http://dx.doi.org/10.1016/j.phyplu.2021.100029]
[5]
Riaz M, Khalid R, Afzal M, et al. Phytobioactive compounds as therapeutic agents for human diseases: A review. Food Sci Nutr 2023; 11(6): 2500-29.
[http://dx.doi.org/10.1002/fsn3.3308] [PMID: 37324906]
[6]
Tripathy A, Behera M, Rout AS, Biswal SK, Phule AD. Optical, structural, and antimicrobial study of gold nanoparticles synthesized using an aqueous extract of Mimusops elengi raw fruits. Biointerface Res Appl Chem 2020; 10(6): 7085-96.
[http://dx.doi.org/10.33263/BRIAC106.70857096]
[7]
Achar RR, Gowda NGS, Raju NR, Silina E, Stupin V. Mimusops elengi (Bakula) gelatinolytic protease and its plasmin-like action on the blood clot. Curr Protein Pept Sci 2022; 23(10): 706-12.
[http://dx.doi.org/10.2174/1389203723666220829114301] [PMID: 36043759]
[8]
Charlz Nithin J, Ranjani S, Hemalatha S. Mimusops elengi flower-mediated green silver nanoparticles control staphylococcus aureus and acinetobacter baumannii. Appl Biochem Biotechnol 2022; 194(7): 3066-81.
[http://dx.doi.org/10.1007/s12010-022-03882-z] [PMID: 35347673]
[9]
Arifin B, Nasution R, Desrianti N, Marianne M, Helwati H. Antimicrobial activity of hand lotion of flower Mimusops elengi. Open Access Maced J Med Sci 2019; 7(22): 3748-56.
[http://dx.doi.org/10.3889/oamjms.2019.496] [PMID: 32127968]
[10]
Bhavikatti SK, Karobari MI, Zainuddin SLA, et al. Investigating the antioxidant and cytocompatibility of Mimusops elengi Linn extract over human gingival fibroblast cells. Int J Environ Res Public Health 2021; 18(13): 7162.
[http://dx.doi.org/10.3390/ijerph18137162] [PMID: 34281099]
[11]
Sayed DF, Mohamed MA, Nada AS, Temraz A, Ahmed AH. Hepatoprotective role of myricitrin isolated from Mimusops elengi Linn. leaves extract on γ‐radiation‐induced liver damage in rats: Phyto‐biochemical investigations. Cell Biochem Funct 2023; 41(6): 642-57.
[http://dx.doi.org/10.1002/cbf.3820] [PMID: 37342005]
[12]
Bhavikatti SK, Alqahtani NA. Antimicrobial efficacy of a new Mimusops elengi (Linn) incorporated herbal product on selected oral and periodontal pathogens: An in vitro microbiological study. J Biol Regul Homeost Agents 2020; 34(2): 635-41.
[PMID: 32425016]
[13]
Bhavikatti SK, Alqahtani NA, Bhat KG, Aggarwal VP, Karobari MI. Evaluation of the anti-inflammatory activity of a Mimusops elengi (linn)-incorporated herbal product: A zymographic analysis. J Biol Regul Homeost Agents 2020; 34(1): 157-62.
[PMID: 32048499]
[14]
Gillani SS, Shahwar D. Investigation of antioxidant activity in Mimusops elengi. J Plant Biochem Physiol 2017; 5: 202.
[15]
Shaikh JR, Patil MK. Qualitative tests for preliminary phytochemical screening: An overview. Int J Chem Stud 2020; 8(2): 603-8.
[http://dx.doi.org/10.22271/chemi.2020.v8.i2i.8834]
[16]
Munteanu IG, Apetrei C. Analytical methods used in determining antioxidant activity: A review. Int J Mol Sci 2021; 22(7): 3380.
[http://dx.doi.org/10.3390/ijms22073380] [PMID: 33806141]
[17]
Sharma OP, Bhat TK. DPPH antioxidant assay revisited. Food Chem 2009; 113(4): 1202-5.
[http://dx.doi.org/10.1016/j.foodchem.2008.08.008]
[18]
Oyaizu M. Studies on product of browning reaction prepared from glucose amine. Jpn J Nutr 1986; 44: 307-15.
[http://dx.doi.org/10.5264/eiyogakuzashi.44.307]
[19]
Sreejayan N, Rao MNA. Nitric oxide scavenging by curcuminoids. J Pharm Pharmacol 2011; 49(1): 105-7.
[http://dx.doi.org/10.1111/j.2042-7158.1997.tb06761.x] [PMID: 9120760]
[20]
Wani A, Kumar M. Antimicrobial activity of Juglans regia root bark extracts. J Pharmaceut Technol. Res Manage 2020; 8(2): 59-65.
[http://dx.doi.org/10.15415/jptrm.2020.82007]
[21]
Behl T, Bungau S, Kumar K, et al. Pleotropic effects of polyphenols in cardiovascular system. Biomed Pharmacother 2020; 130: 110714.
[http://dx.doi.org/10.1016/j.biopha.2020.110714] [PMID: 34321158]
[22]
Behl T, Kumar K, Brisc C, et al. Exploring the multifocal role of phytochemicals as immunomodulators. Biomed Pharmacother 2021; 133: 110959.
[http://dx.doi.org/10.1016/j.biopha.2020.110959] [PMID: 33197758]
[23]
Radi R. Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine. Proc Natl Acad Sci 2018; 115(23): 5839-48.
[http://dx.doi.org/10.1073/pnas.1804932115] [PMID: 29802228]
[24]
Chassagne F, Samarakoon T, Porras G, et al. A systematic review of plants with antibacterial activities: A taxonomic and phylogenetic perspective. Front Pharmacol 2021; 11: 586548.
[http://dx.doi.org/10.3389/fphar.2020.586548] [PMID: 33488385]
[25]
Parham S, Kharazi AZ, Bakhsheshi-Rad HR, et al. Antioxidant, antimicrobial and antiviral properties of herbal materials. Antioxidants 2020; 9(12): 1309.
[http://dx.doi.org/10.3390/antiox9121309] [PMID: 33371338]

Rights & Permissions Print Cite
© 2025 Bentham Science Publishers | Privacy Policy