Formulation and Antimicrobial Screening of Tea Tree Oil Gel

Karan      Agrawal; Vibha      Kumari; Talever      Singh; Devender      Pathak; Mayank      Kulshreshtha

doi:10.2174/0126668629261287231002101556

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Abstract

Objective: An acne is a frequent form of skin condition brought on by an overproduction of the particular oil “sebum”, which is produced by the sebaceous gland. This oil accumulates in the fol-licles and causes the swelling of pores. Many microbial species such as Staphylococcus aureus, Bacillus subtills, Escherichia coli, Pseudomonas aeruginosa, Aspergillus tubingensis etc. are responsible for acne directly or indirectly. The aim of this study was to synthesise the herbal gel of tea tree oil obtained from the plant M.alternifolia.

Material and Methods: The gel was prepared using Carbopol-940 as a gelling agent using the swelling method and parameters like spreadability, extrudability, pH, etc were also determined. Zone of inhibi-tion (ZOI) was estimated with renowned standards (Ciprofloxacin and fluconazole).

Results: Studies revealed that the gel was highly effective against the selected species except fungal strains. ZIC was observed ranging from 1.6±0.01mm to 14.9±0.43mm. The maximum ZOI was ob-served (14.9±0.43) against Staphylococcus aureus. The physical properties of the gel satisfied the stand-ard parameters.

Conclusion: The herbal gel was found to be highly promising activity against bacterial species associ-ated with acne in a concentration-dependent manner, but more research is needed.

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DOI https://dx.doi.org/10.2174/0126668629261287231002101556	Print ISSN 2666-8629
Publisher Name Bentham Science Publisher	Online ISSN 2666-8637

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