CircRNAs as a Novel Class of Potential Diagnostic Biomarkers in Bipolar Disorders

McIntyre, R.S.; Berk, M.; Brietzke, E.; Goldstein, B.I.; López-Jaramillo, C.; Kessing, L.V.; Malhi, G.S.; Nierenberg, A.A.; Rosenblat, J.D.; Majeed, A.; Vieta, E.; Vinberg, M.; Young, A.H.; Mansur, R.B. Bipolar disorders. Lancet, 2020, 396(10265), 1841-1856.
[http://dx.doi.org/10.1016/S0140-6736(20)31544-0] [PMID: 33278937]

Shao, L.; Vawter, M.P. Shared gene expression alterations in schizophrenia and bipolar disorder. Biol. Psychiatry, 2008, 64(2), 89-97.
[http://dx.doi.org/10.1016/j.biopsych.2007.11.010] [PMID: 18191109]

Craddock, N.; Sklar, P. Genetics of bipolar disorder. Lancet, 2013, 381(9878), 1654-1662.
[http://dx.doi.org/10.1016/S0140-6736(13)60855-7] [PMID: 23663951]

Psychiatric GWAS Consortium Bipolar Disorder Working Group.. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat. Genet., 2011, 43(10), 977-983.
[http://dx.doi.org/10.1038/ng.943] [PMID: 21926972]

Stahl, E.A.; Breen, G.; Forstner, A.J.; McQuillin, A.; Ripke, S.; Trubetskoy, V.; Mattheisen, M.; Wang, Y.; Coleman, J.R.I.; Gaspar, H.A.; de Leeuw, C.A.; Steinberg, S.; Pavlides, J.M.W.; Trzaskowski, M.; Byrne, E.M.; Pers, T.H.; Holmans, P.A.; Richards, A.L.; Abbott, L.; Agerbo, E.; Akil, H.; Albani, D.; Alliey-Rodriguez, N.; Als, T.D.; Anjorin, A.; Antilla, V.; Awasthi, S.; Badner, J.A.; Bækvad-Hansen, M.; Barchas, J.D.; Bass, N.; Bauer, M.; Belliveau, R.; Bergen, S.E.; Pedersen, C.B.; Bøen, E.; Boks, M.P.; Boocock, J.; Budde, M.; Bunney, W.; Burmeister, M.; Bybjerg-Grauholm, J.; Byerley, W.; Casas, M.; Cerrato, F.; Cervantes, P.; Chambert, K.; Charney, A.W.; Chen, D.; Churchhouse, C.; Clarke, T.K.; Coryell, W.; Craig, D.W.; Cruceanu, C.; Curtis, D.; Czerski, P.M.; Dale, A.M.; de Jong, S.; Degenhardt, F.; Del-Favero, J.; DePaulo, J.R.; Djurovic, S.; Dobbyn, A.L.; Dumont, A.; Elvsåshagen, T.; Escott-Price, V.; Fan, C.C.; Fischer, S.B.; Flickinger, M.; Foroud, T.M.; Forty, L.; Frank, J.; Fraser, C.; Freimer, N.B.; Frisén, L.; Gade, K.; Gage, D.; Garnham, J.; Giambartolomei, C.; Pedersen, M.G.; Goldstein, J.; Gordon, S.D.; Gordon-Smith, K.; Green, E.K.; Green, M.J.; Greenwood, T.A.; Grove, J.; Guan, W.; Guzman-Parra, J.; Hamshere, M.L.; Hautzinger, M.; Heilbronner, U.; Herms, S.; Hipolito, M.; Hoffmann, P.; Holland, D.; Huckins, L.; Jamain, S.; Johnson, J.S.; Juréus, A.; Kandaswamy, R.; Karlsson, R.; Kennedy, J.L.; Kittel-Schneider, S.; Knowles, J.A.; Kogevinas, M.; Koller, A.C.; Kupka, R.; Lavebratt, C.; Lawrence, J.; Lawson, W.B.; Leber, M.; Lee, P.H.; Levy, S.E.; Li, J.Z.; Liu, C.; Lucae, S.; Maaser, A.; MacIntyre, D.J.; Mahon, P.B.; Maier, W.; Martinsson, L.; McCarroll, S.; McGuffin, P.; McInnis, M.G.; McKay, J.D.; Medeiros, H.; Medland, S.E.; Meng, F.; Milani, L.; Montgomery, G.W.; Morris, D.W.; Mühleisen, T.W.; Mullins, N.; Nguyen, H.; Nievergelt, C.M.; Adolfsson, A.N.; Nwulia, E.A.; O’Donovan, C.; Loohuis, L.M.O.; Ori, A.P.S.; Oruc, L.; Ösby, U.; Perlis, R.H.; Perry, A.; Pfennig, A.; Potash, J.B.; Purcell, S.M.; Regeer, E.J.; Reif, A.; Reinbold, C.S.; Rice, J.P.; Rivas, F.; Rivera, M.; Roussos, P.; Ruderfer, D.M.; Ryu, E.; Sánchez-Mora, C.; Schatzberg, A.F.; Scheftner, W.A.; Schork, N.J.; Shannon Weickert, C.; Shehktman, T.; Shilling, P.D.; Sigurdsson, E.; Slaney, C.; Smeland, O.B.; Sobell, J.L.; Søholm Hansen, C.; Spijker, A.T.; St Clair, D.; Steffens, M.; Strauss, J.S.; Streit, F.; Strohmaier, J.; Szelinger, S.; Thompson, R.C.; Thorgeirsson, T.E.; Treutlein, J.; Vedder, H.; Wang, W.; Watson, S.J.; Weickert, T.W.; Witt, S.H.; Xi, S.; Xu, W.; Young, A.H.; Zandi, P.; Zhang, P.; Zöllner, S.; Adolfsson, R.; Agartz, I.; Alda, M.; Backlund, L.; Baune, B.T.; Bellivier, F.; Berrettini, W.H.; Biernacka, J.M.; Blackwood, D.H.R.; Boehnke, M.; Børglum, A.D.; Corvin, A.; Craddock, N.; Daly, M.J.; Dannlowski, U.; Esko, T.; Etain, B.; Frye, M.; Fullerton, J.M.; Gershon, E.S.; Gill, M.; Goes, F.; Grigoroiu-Serbanescu, M.; Hauser, J.; Hougaard, D.M.; Hultman, C.M.; Jones, I.; Jones, L.A.; Kahn, R.S.; Kirov, G.; Landén, M.; Leboyer, M.; Lewis, C.M.; Li, Q.S.; Lissowska, J.; Martin, N.G.; Mayoral, F.; McElroy, S.L.; McIntosh, A.M.; McMahon, F.J.; Melle, I.; Metspalu, A.; Mitchell, P.B.; Morken, G.; Mors, O.; Mortensen, P.B.; Müller-Myhsok, B.; Myers, R.M.; Neale, B.M.; Nimgaonkar, V.; Nordentoft, M.; Nöthen, M.M.; O’Donovan, M.C.; Oedegaard, K.J.; Owen, M.J.; Paciga, S.A.; Pato, C.; Pato, M.T.; Posthuma, D.; Ramos-Quiroga, J.A.; Ribasés, M.; Rietschel, M.; Rouleau, G.A.; Schalling, M.; Schofield, P.R.; Schulze, T.G.; Serretti, A.; Smoller, J.W.; Stefansson, H.; Stefansson, K.; Stordal, E.; Sullivan, P.F.; Turecki, G.; Vaaler, A.E.; Vieta, E.; Vincent, J.B.; Werge, T.; Nurnberger, J.I.; Wray, N.R.; Di Florio, A.; Edenberg, H.J.; Cichon, S.; Ophoff, R.A.; Scott, L.J.; Andreassen, O.A.; Kelsoe, J.; Sklar, P. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nat. Genet., 2019, 51(5), 793-803.
[http://dx.doi.org/10.1038/s41588-019-0397-8] [PMID: 31043756]

Cruceanu, C.; Ambalavanan, A.; Spiegelman, D.; Gauthier, J.; Lafrenière, R.G.; Dion, P.A.; Alda, M.; Turecki, G.; Rouleau, G.A. Family-based exome-sequencing approach identifies rare susceptibility variants for lithium-responsive bipolar disorder. Genome, 2013, 56(10), 634-640.
[http://dx.doi.org/10.1139/gen-2013-0081] [PMID: 24237345]

Goes, F.S.; Pirooznia, M.; Parla, J.S.; Kramer, M.; Ghiban, E.; Mavruk, S.; Chen, Y.C.; Monson, E.T.; Willour, V.L.; Karchin, R.; Flickinger, M.; Locke, A.E.; Levy, S.E.; Scott, L.J.; Boehnke, M.; Stahl, E.; Moran, J.L.; Hultman, C.M.; Landén, M.; Purcell, S.M.; Sklar, P.; Zandi, P.P.; McCombie, W.R.; Potash, J.B. Exome sequencing of familial bipolar disorder. JAMA Psychiatry, 2016, 73(6), 590-597.
[http://dx.doi.org/10.1001/jamapsychiatry.2016.0251] [PMID: 27120077]

Middleton, F.A.; Pato, C.N.; Gentile, K.L.; McGann, L.; Brown, A.M.; Trauzzi, M. Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches. Am. J. Med. Genet. B Neuropsychiatr. Genet., 2005, 136B(1), 12-25.
[http://dx.doi.org/10.1002/ajmg.b.30171] [PMID: 15892139]

Cardamone, G.; Paraboschi, E.M.; Soldà, G.; Liberatore, G.; Rimoldi, V.; Cibella, J.; Airi, F.; Tisato, V.; Cantoni, C.; Gallia, F.; Gemmati, D.; Piccio, L.; Duga, S.; Nobile-Orazio, E.; Asselta, R. The circular RNA landscape in multiple sclerosis: Disease-specific associated variants and exon methylation shape circular RNA expression profile. Mult. Scler. Relat. Disord., 2023, 69, 104426.
[http://dx.doi.org/10.1016/j.msard.2022.104426] [PMID: 36446168]

Mahmoudi, E.; Green, M.J.; Cairns, M.J. Dysregulation of circRNA expression in the peripheral blood of individuals with schizophrenia and bipolar disorder. J. Mol. Med., 2021, 99(7), 981-991.
[http://dx.doi.org/10.1007/s00109-021-02070-6] [PMID: 33782720]

Ren, Z.; Chu, C.; Pang, Y.; Cai, H.; Jia, L. A circular RNA blood panel that differentiates Alzheimer’s disease from other dementia types. Biomark. Res., 2022, 10(1), 63.
[http://dx.doi.org/10.1186/s40364-022-00405-0] [PMID: 35982472]

Dorostgou, Z.; Yadegar, N.; Dorostgou, Z.; Khorvash, F.; Vakili, O. Novel insights into the role of circular RNAS in Parkinson disease: An emerging renaissance in the management of neurodegenerative diseases. J. Neurosci. Res., 2022, 100(9), 1775-1790.
[http://dx.doi.org/10.1002/jnr.25094] [PMID: 35642104]

Mao, Q.; Tian, L.; Wei, J.; Zhou, X.; Cheng, H.; Zhu, X.; Li, X.; Gao, Z.; Zhang, X.; Liang, L. Transcriptome analysis of microRNAs, circRNAs, and mRNAs in the dorsal root ganglia of paclitaxel-induced mice with neuropathic pain. Front. Mol. Neurosci., 2022, 15, 990260.
[http://dx.doi.org/10.3389/fnmol.2022.990260] [PMID: 36117915]

Özerdem, A.; Ceylan, D.; Can, G. Neurobiology of risk for bipolar disorder. Curr. Treat. Options Psychiatry, 2016, 3(4), 315-329.
[http://dx.doi.org/10.1007/s40501-016-0093-6] [PMID: 27867834]

Ashwal-Fluss, R.; Meyer, M.; Pamudurti, N.R.; Ivanov, A.; Bartok, O.; Hanan, M.; Evantal, N.; Memczak, S.; Rajewsky, N.; Kadener, S. circRNA biogenesis competes with pre-mRNA splicing. Mol. Cell, 2014, 56(1), 55-66.
[http://dx.doi.org/10.1016/j.molcel.2014.08.019] [PMID: 25242144]

Li, Z.; Huang, C.; Bao, C.; Chen, L.; Lin, M.; Wang, X.; Zhong, G.; Yu, B.; Hu, W.; Dai, L.; Zhu, P.; Chang, Z.; Wu, Q.; Zhao, Y.; Jia, Y.; Xu, P.; Liu, H.; Shan, G. Exon-intron circular RNAs regulate transcription in the nucleus. Nat. Struct. Mol. Biol., 2015, 22(3), 256-264.
[http://dx.doi.org/10.1038/nsmb.2959] [PMID: 25664725]

Zhang, X.O.; Wang, H.B.; Zhang, Y.; Lu, X.; Chen, L.L.; Yang, L. Complementary sequence-mediated exon circularization. Cell, 2014, 159(1), 134-147.
[http://dx.doi.org/10.1016/j.cell.2014.09.001] [PMID: 25242744]

Starke, S.; Jost, I.; Rossbach, O.; Schneider, T.; Schreiner, S.; Hung, L.H.; Bindereif, A. Exon circularization requires canonical splice signals. Cell Rep., 2015, 10(1), 103-111.
[http://dx.doi.org/10.1016/j.celrep.2014.12.002] [PMID: 25543144]

Bachmayr-Heyda, A.; Reiner, A.T.; Auer, K.; Sukhbaatar, N.; Aust, S.; Bachleitner-Hofmann, T.; Mesteri, I.; Grunt, T.W.; Zeillinger, R.; Pils, D. Correlation of circular RNA abundance with proliferation – exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis and normal human tissues. Sci. Rep., 2015, 5(1), 8057.
[http://dx.doi.org/10.1038/srep08057] [PMID: 25624062]

Li, Y.; Zheng, Q.; Bao, C.; Li, S.; Guo, W.; Zhao, J.; Chen, D.; Gu, J.; He, X.; Huang, S. Circular RNA is enriched and stable in exosomes: A promising biomarker for cancer diagnosis. Cell Res., 2015, 25(8), 981-984.
[http://dx.doi.org/10.1038/cr.2015.82] [PMID: 26138677]

Lukiw, W.J. Circular RNA (circRNA) in Alzheimer’s disease (AD). Front. Genet., 2013, 4, 307.
[http://dx.doi.org/10.3389/fgene.2013.00307] [PMID: 24427167]

Memczak, S.; Jens, M.; Elefsinioti, A.; Torti, F.; Krueger, J.; Rybak, A.; Maier, L.; Mackowiak, S.D.; Gregersen, L.H.; Munschauer, M.; Loewer, A.; Ziebold, U.; Landthaler, M.; Kocks, C.; le Noble, F.; Rajewsky, N. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature, 2013, 495(7441), 333-338.
[http://dx.doi.org/10.1038/nature11928] [PMID: 23446348]

Hansen, T.B.; Jensen, T.I.; Clausen, B.H.; Bramsen, J.B.; Finsen, B.; Damgaard, C.K.; Kjems, J. Natural RNA circles function as efficient microRNA sponges. Nature, 2013, 495(7441), 384-388.
[http://dx.doi.org/10.1038/nature11993] [PMID: 23446346]

Guo, J.U.; Agarwal, V.; Guo, H.; Bartel, D.P. Expanded identification and characterization of mammalian circular RNAs. Genome Biol., 2014, 15(7), 409.
[http://dx.doi.org/10.1186/s13059-014-0409-z] [PMID: 25070500]

Han, D.; Li, J.; Wang, H.; Su, X.; Hou, J.; Gu, Y.; Qian, C.; Lin, Y.; Liu, X.; Huang, M.; Li, N.; Zhou, W.; Yu, Y.; Cao, X. Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression. Hepatology, 2017, 66(4), 1151-1164.
[http://dx.doi.org/10.1002/hep.29270] [PMID: 28520103]

Du, W.W.; Yang, W.; Liu, E.; Yang, Z.; Dhaliwal, P.; Yang, B.B. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res., 2016, 44(6), 2846-2858.
[http://dx.doi.org/10.1093/nar/gkw027] [PMID: 26861625]

You, X.; Vlatkovic, I.; Babic, A.; Will, T.; Epstein, I.; Tushev, G.; Akbalik, G.; Wang, M.; Glock, C.; Quedenau, C.; Wang, X.; Hou, J.; Liu, H.; Sun, W.; Sambandan, S.; Chen, T.; Schuman, E.M.; Chen, W. Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. Nat. Neurosci., 2015, 18(4), 603-610.
[http://dx.doi.org/10.1038/nn.3975] [PMID: 25714049]

Conn, S.J.; Pillman, K.A.; Toubia, J.; Conn, V.M.; Salmanidis, M.; Phillips, C.A.; Roslan, S.; Schreiber, A.W.; Gregory, P.A.; Goodall, G.J. The RNA binding protein quaking regulates formation of circRNAs. Cell, 2015, 160(6), 1125-1134.
[http://dx.doi.org/10.1016/j.cell.2015.02.014] [PMID: 25768908]

Yang, Y.; Fan, X.; Mao, M.; Song, X.; Wu, P.; Zhang, Y.; Jin, Y.; Yang, Y.; Chen, L.L.; Wang, Y.; Wong, C.C.L.; Xiao, X.; Wang, Z. Extensive translation of circular RNAs driven by N⁶-methyladenosine. Cell Res., 2017, 27(5), 626-641.
[http://dx.doi.org/10.1038/cr.2017.31] [PMID: 28281539]

Legnini, I.; Di Timoteo, G.; Rossi, F.; Morlando, M.; Briganti, F.; Sthandier, O.; Fatica, A.; Santini, T.; Andronache, A.; Wade, M.; Laneve, P.; Rajewsky, N.; Bozzoni, I. Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis. Mol. Cell, 2017, 66(1), 22-37.e9.
[http://dx.doi.org/10.1016/j.molcel.2017.02.017] [PMID: 28344082]

Rybak-Wolf, A.; Stottmeister, C.; Glažar, P.; Jens, M.; Pino, N.; Giusti, S.; Hanan, M.; Behm, M.; Bartok, O.; Ashwal-Fluss, R.; Herzog, M.; Schreyer, L.; Papavasileiou, P.; Ivanov, A.; Öhman, M.; Refojo, D.; Kadener, S.; Rajewsky, N. Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed. Mol. Cell, 2015, 58(5), 870-885.
[http://dx.doi.org/10.1016/j.molcel.2015.03.027] [PMID: 25921068]

Sekar, S.; Liang, W.S. Circular RNA expression and function in the brain. Noncoding RNA Res., 2019, 4(1), 23-29.
[http://dx.doi.org/10.1016/j.ncrna.2019.01.001] [PMID: 30891534]

Hanan, M.; Soreq, H.; Kadener, S. CircRNAs in the brain. RNA Biol., 2017, 14(8), 1028-1034.
[http://dx.doi.org/10.1080/15476286.2016.1255398] [PMID: 27892769]

Luykx, J.J.; Giuliani, F.; Giuliani, G.; Veldink, J. Coding and non-coding RNA abnormalities in bipolar disorder. Genes, 2019, 10(11), 946.
[http://dx.doi.org/10.3390/genes10110946] [PMID: 31752442]

Dines, M.; Lamprecht, R. The role of ephs and ephrins in memory formation. Int. J. Neuropsychopharmacol., 2016, 19(4), pyv106.
[http://dx.doi.org/10.1093/ijnp/pyv106] [PMID: 26371183]

Dines, M.; Lamprecht, R. EphrinA4 mimetic peptide targeted to EphA binding site impairs the formation of long-term fear memory in lateral amygdala. Transl. Psychiatry, 2014, 4(9), e450.
[http://dx.doi.org/10.1038/tp.2014.76] [PMID: 25268254]

Attwood, B.K.; Bourgognon, J.M.; Patel, S.; Mucha, M.; Schiavon, E.; Skrzypiec, A.E.; Young, K.W.; Shiosaka, S.; Korostynski, M.; Piechota, M.; Przewlocki, R.; Pawlak, R. Neuropsin cleaves EphB2 in the amygdala to control anxiety. Nature, 2011, 473(7347), 372-375.
[http://dx.doi.org/10.1038/nature09938] [PMID: 21508957]

Shi, Y.; Song, R.; Wang, Z.; Zhang, H.; Zhu, J.; Yue, Y.; Zhao, Y.; Zhang, Z. Potential clinical value of circular RNAs as peripheral biomarkers for the diagnosis and treatment of major depressive disorder. EBioMedicine, 2021, 66, 103337.
[http://dx.doi.org/10.1016/j.ebiom.2021.103337] [PMID: 33862583]

Zimmerman, A.J.; Hafez, A.K.; Amoah, S.K.; Rodriguez, B.A.; Dell’Orco, M.; Lozano, E.; Hartley, B.J.; Alural, B.; Lalonde, J.; Chander, P.; Webster, M.J.; Perlis, R.H.; Brennand, K.J.; Haggarty, S.J.; Weick, J.; Perrone-Bizzozero, N.; Brigman, J.L.; Mellios, N. A psychiatric disease-related circular RNA controls synaptic gene expression and cognition. Mol. Psychiatry, 2020, 25(11), 2712-2727.
[http://dx.doi.org/10.1038/s41380-020-0653-4] [PMID: 31988434]

Yang, L.; Han, B.; Zhang, Z.; Wang, S.; Bai, Y.; Zhang, Y.; Tang, Y.; Du, L.; Xu, L.; Wu, F.; Zuo, L.; Chen, X.; Lin, Y.; Liu, K.; Ye, Q.; Chen, B.; Li, B.; Tang, T.; Wang, Y.; Shen, L.; Wang, G.; Ju, M.; Yuan, M.; Jiang, W.; Zhang, J.H.; Hu, G.; Wang, J.; Yao, H. Extracellular vesicle–mediated delivery of circular RNA SCMH1 promotes functional recovery in rodent and nonhuman primate ischemic stroke models. Circulation, 2020, 142(6), 556-574.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.120.045765] [PMID: 32441115]

Pan, R.Y.; Liu, P.; Zhou, H.T.; Sun, W.X.; Song, J.; Shu, J.; Cui, G.J.; Yang, Z.J.; Jia, E.Z. Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients. Oncotarget, 2017, 8(36), 60280-60290.
[http://dx.doi.org/10.18632/oncotarget.19941] [PMID: 28947970]

Haque, S.; Harries, L. Circular RNAs (circRNAs) in Health and Disease. Genes, 2017, 8(12), 353.
[http://dx.doi.org/10.3390/genes8120353] [PMID: 29182528]

Gardiner, E.; Beveridge, N.J.; Wu, J.Q.; Carr, V.; Scott, R.J.; Tooney, P.A.; Cairns, M.J. Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells. Mol. Psychiatry, 2012, 17(8), 827-840.
[http://dx.doi.org/10.1038/mp.2011.78] [PMID: 21727898]

Lin, R.; Lopez, J.P.; Cruceanu, C.; Pierotti, C.; Fiori, L.M.; Squassina, A.; Chillotti, C.; Dieterich, C.; Mellios, N.; Turecki, G. Circular RNA circCCNT2 is upregulated in the anterior cingulate cortex of individuals with bipolar disorder. Transl. Psychiatry, 2021, 11(1), 629.
[http://dx.doi.org/10.1038/s41398-021-01746-4] [PMID: 34893581]

Cruceanu, C.; Tan, P.P.C.; Rogic, S.; Lopez, J.P.; Torres-Platas, S.G.; Gigek, C.O.; Alda, M.; Rouleau, G.A.; Pavlidis, P.; Turecki, G. Transcriptome sequencing of the anterior cingulate in bipolar disorder: Dysregulation of G protein-coupled receptors. Am. J. Psychiatry, 2015, 172(11), 1131-1140.
[http://dx.doi.org/10.1176/appi.ajp.2015.14101279] [PMID: 26238605]

Liu, Y.; Guo, J.; Shen, K.; Wang, R.; Chen, C.; Liao, Z.; Zhou, J. Paclitaxel suppresses hepatocellular carcinoma tumorigenesis through regulating Circ-BIRC6/miR-877-5p/YWHAZ axis. OncoTargets Ther., 2020, 13, 9377-9388.
[http://dx.doi.org/10.2147/OTT.S261700] [PMID: 33061425]

Yu, Y.; Bian, L.; Liu, R.; Wang, Y.; Xiao, X. Circular RNA hsa_circ_0061395 accelerates hepatocellular carcinoma progression via regulation of the miR-877-5p/PIK3R3 axis. Cancer Cell Int., 2021, 21(1), 10.
[http://dx.doi.org/10.1186/s12935-020-01695-w] [PMID: 33407443]

Fu, Y.; He, W.; Zhou, C.; Fu, X.; Wan, Q.; He, L.; Wei, B. Bioinformatics analysis of circRNA expression and construction of “circRNA-miRNA-mRNA” competing endogenous RNAs networks in bipolar disorder patients. Front. Genet., 2021, 12, 718976.
[http://dx.doi.org/10.3389/fgene.2021.718976] [PMID: 34422020]