A Mini Review of the Literature with a Special Focus on India on the
Prevalence of Indian Traditional Medicine (ITM) use During Pregnancy

Pranay      Wal; Biswajit      Dash; Divyanshi      Gupta; Srishti      Morris; Prachi; Vibhu      Sahani; Awani   K.   Rai; Ankita      Wal

doi:10.2174/1573404820666230712125718

Abstract

Background: Although pregnancy has been an integral part of women’s lives for millennia, not all women have found the process comfortable. About 65 percent of women in India consume Indian traditional herbs during pregnancy. Herbal medicines are used nowadays by up to half of the world's population. Phytomedicines isolated from plants contain a wide variety of bioactive components that can have both negative and positive effects. Many herbal plants, such as Sage (Salvia fruticosa), golden cotula (Matricaria aurea), anise (P. anisum), peppermint (Mentha aquatica), and cumin (Cuminum cyminum), etc., are used in pregnancy. To minimize the adverse effects, the use of Indian traditional medicine can be the best possible alternative.

Objective: Regarding the usage of herbal medicines in India, there are large research gaps and a lack of a regulatory framework. This article aims to highlight the most common traditional Indian remedies used by pregnant women, along with their uses and any possible interactions between herbal remedies and prescription drugs.

Method: Several databases, including the WHO guidelines, PubMed, Bentham Science, Elsevier, Springer Nature, Wiley, and Research Gate, were used to compile the data for the article following a thorough analysis of the various research findings connected to pregnancy and herbs for pregnancy care.

Result: An overview of the use of herbal medicine is given in this review, along with information on its limitations and general safety. The prevalence of herbal medicine use during pregnancy in India is then discussed, along with the uses, adverse effects, side effects, and efficacy of the most popular herbal medications.

Conclusion: The use of herbal medicine during pregnancy is a common phenomenon. The outcomes of this study showed Indian Traditional medicines are known to have numerous advantages that can be helpful during or after pregnancy, including raising milk production, reducing nausea, easing labor pains, reducing morning sickness, or reducing flatulence, however, some herbal remedies have the potential to be teratogenic, poisonous, and abortive, especially during the first trimester of pregnancy because the active components of some medicinal plants can cross the placental barrier and get to the foetus. To determine the safety of taking herbal medications, studies, especially clinical trial trials, must be conducted.

Graphical Abstract

[1]
Rais-ur-Rahman, R.R. Need of standardization and quality control of herbal drugs in this Era. Annals of Phytomedicine: An International Journal.,  2017, 6(2)

[2]
Barnes, J. The international society of pharmacovigilance (ISoP) special interest group on herbal and traditional medicines: Towards progress in pharmacovigilance for herbal and traditional medicines and other “natural health” products. Drug Saf.,  2020, 43(7), 619-622.
 [http://dx.doi.org/10.1007/s40264-020-00937-0] [PMID: 32328906]

[3]
Winslow, L.C.; Kroll, D.J. Herbs as medicines. Arch. Intern. Med.,  1998, 158(20), 2192-2199.
 [http://dx.doi.org/10.1001/archinte.158.20.2192] [PMID: 9818799]

[4]
 Guidelines for the assessment of herbal medicines 2022. Avaialable From:
          https://ayurvedaresearchabstracts.blogspot.com/2017/07/guidelines-for-assessment-of-herbal.html

[5]
Tiran, D. The use of herbs by pregnant and childbearing women: A risk–benefit assessment. Complement. Ther. Nurs. Midwifery,  2003, 9(4), 176-181.
 [http://dx.doi.org/10.1016/S1353-6117(03)00045-3] [PMID: 14556766]

[6]
Frawley, J.; Adams, J.; Steel, A.; Broom, A.; Gallois, C.; Sibbritt, D. Women’s use and self-prescription of herbal medicine during pregnancy: An examination of 1,835 pregnant women. Womens Health Issues,  2015, 25(4), 396-402.
 [http://dx.doi.org/10.1016/j.whi.2015.03.001] [PMID: 25935822]

[7]
Dugoua, J.J.; Seely, D.; Perri, D.; Cooley, K.; Forelli, T.; Mills, E.; Koren, G. From type 2 diabetes to antioxidant activity: A systematic review of the safety and efficacy of common and cassia cinnamon bark This article is one of a selection of papers published in this special issue (part 1 of 2) on the safety and efficacy of natural health products. Can. J. Physiol. Pharmacol.,  2007, 85(9), 837-847.
 [http://dx.doi.org/10.1139/Y07-080] [PMID: 18066129]

[8]
Dove, N. A return to traditional health care practices. J. Black Stud.,  2010, 40(5), 823-834.
 [http://dx.doi.org/10.1177/0021934708320001]

[9]
Mogawane, M.A.; Mothiba, T.M.; Malema, R.N. Indigenous practices of pregnant women at Dilokong hospital in Limpopo province, South Africa. Curationis,  2015, 38(2), 1553.
 [http://dx.doi.org/10.4102/curationis.v38i2.1553] [PMID: 26842096]

[10]
Zagorodnikova, K.; Lupattelli, A.; Pokladova, M.; Nordeng, H. Use of herbal medicines during pregnancy by women in Russia. Reprod. Toxicol.,  2016, 60, 187.
 [http://dx.doi.org/10.1016/j.reprotox.2016.03.038]

[11]
Maputle, S.M.; Mothiba, T.M.; Maliwichi, L. Traditional medicine and pregnancy management: Perceptions of traditional health practitioners in Capricorn District, Limpopo Province. Stud. Ethno-Med.,  2015, 9(1), 67-75.
 [http://dx.doi.org/10.1080/09735070.2015.11905422]

[12]
Varga, C.A.; Veale, D.J.H. Isihlambezo: Utilization patterns and potential health effects of pregnancy-related traditional herbal medicine. Soc. Sci. Med.,  1997, 44(7), 911-924.
 [http://dx.doi.org/10.1016/S0277-9536(96)00104-9] [PMID: 9089914]

[13]
Kennedy, D.A.; Lupattelli, A.; Koren, G.; Nordeng, H. Herbal medicine use in pregnancy: Results of a multinational study. BMC Complement. Altern. Med.,  2013, 13(1), 355.
 [http://dx.doi.org/10.1186/1472-6882-13-355] [PMID: 24330413]

[14]
Adams, J.; Lui, C.W.; Sibbritt, D.; Broom, A.; Wardle, J.; Homer, C.; Beck, S. Women’s use of complementary and alternative medicine during pregnancy. Obstet. Anesthes. Dig.,  2010, 30(4), 238.
 [http://dx.doi.org/10.1097/01.aoa.0000389618.03414.70]

[15]
Pallivalapila, A.R.; Stewart, D.; Shetty, A.; Pande, B.; Singh, R.; McLay, J.S. Use of complementary and alternative medicines during the third trimester. Obstet. Gynecol.,  2015, 125(1), 204-211.
 [http://dx.doi.org/10.1097/AOG.0000000000000596] [PMID: 25560126]

[16]
Westfall, R.E. Herbal medicine in pregnancy and childbirth. Adv. Ther.,  2001, 18(1), 47-55.
 [http://dx.doi.org/10.1007/BF02850250] [PMID: 11512532]

[17]
Nordeng, H.; Havnen, G.C. Use of herbal drugs in pregnancy: A survey among 400 Norwegian women. Pharmacoepidemiol. Drug Saf.,  2004, 13(6), 371-380.
 [http://dx.doi.org/10.1002/pds.945] [PMID: 15170766]

[18]
Laelago, T.; Yohannes, T.; Lemango, F. Prevalence of herbal medicine use and associated factors among pregnant women attending antenatal care at public health facilities in Hossana Town, Southern Ethiopia: Facility based cross sectional study. Arch. Public Health,  2016, 74(1), 7.
 [http://dx.doi.org/10.1186/s13690-016-0118-z] [PMID: 26881052]

[19]
Pallivalappila, A.R.; Stewart, D.; Shetty, A.; Pande, B.; Singh, R.; Mclay, J.S. Complementary and alternative medicine use during early pregnancy. Eur. J. Obstet. Gynecol. Reprod. Biol.,  2014, 181, 251-255.
 [http://dx.doi.org/10.1016/j.ejogrb.2014.08.017] [PMID: 25190299]

[20]
Kavurt, S.; Bas, A.Y.; Aydemir, O.; Yucel, H.; Isıkoglu, S.; Demirel, N. The effect of galactagogue herbal tea on oxidant and anti-oxidant status of human milk. J. Matern. Fetal Neonatal Med.,  2013, 26(10), 1048-1051.
 [http://dx.doi.org/10.3109/14767058.2013.766690] [PMID: 23363373]

[21]
Vaidya, A.D.B.; Devasagayam, T.P.A. Current status of herbal drugs in India: An overview. J. Clin. Biochem. Nutr.,  2007, 41(1), 1-11.
 [http://dx.doi.org/10.3164/jcbn.2007001] [PMID: 18392106]

[22]
Palmer, M.E.; Haller, C.; McKinney, P.E.; Klein-Schwartz, W.; Tschirgi, A.; Smolinske, S.C.; Woolf, A.; Sprague, B.M.; Ko, R.; Everson, G.; Nelson, L.S.; Dodd-Butera, T.; Bartlett, W.D.; Landzberg, B.R. Adverse events associated with dietary supplements: An observational study. Lancet,  2003, 361(9352), 101-106.
 [http://dx.doi.org/10.1016/S0140-6736(03)12227-1] [PMID: 12531576]

[23]
Izzo, A.A.; Ernst, E. Interactions between herbal medicines and prescribed drugs: An updated systematic review. Drugs,  2009, 69(13), 1777-1798.
 [http://dx.doi.org/10.2165/11317010-000000000-00000] [PMID: 19719333]

[24]
Smith-Levitin, M.; Rochelson, B.; Blitz, M. Severe hyponatremia associated with use of black cohosh during prolonged labor and unsuccessful home birth. AJP Rep.,  2016, 6(1), e121-e124.
 [http://dx.doi.org/10.1055/s-0036-1579537] [PMID: 26989565]

[25]
Wong, A.; Dargan, P.; Koutsogiannis, Z.; Sokol, J.; Ramkrishna, J.; Greene, S.L. Chronic Ayurvedic medicine use associated with major and fatal congenital abnormalities. Med. J. Aust.,  2015, 203(11), 443-444.
 [http://dx.doi.org/10.5694/mja15.00636] [PMID: 26654614]

[26]
Koli, D. PA01.78. Ayurvedic diet in pregnancy. Anc. Sci. Life,  2012, 32(5), 128.
 [http://dx.doi.org/10.4103/0257-7941.112136]

[27]
 An Ayurvedic View on Pregnancy & Early Motherhood | Maharishi Ayurveda. 2023. Available From:
          https://mapi.com/blogs/articles/an-ayurvedic-view-on-pregnancy-and-early-motherhood

[28]
Ganer, J.M.; Baragi, U.C. Role of diet and nutrition in pregnancy – An Ayurvedic Perspective. Journal of Ayurveda and Integrated Medical Sciences,  2017, 1(4)

[29]
Mali, B.G. A review on ayurvedic perspective of garbhini chardi (vomiting in pregnancy) management. Nat J Res Ayurved Sci.,  2019, 7(5)
 [http://dx.doi.org/10.52482/ayurlog.v7i05.434]

[30]
Wen, S-H.; Chang, W-C.; Shen, H-S. Wu, H-C Prescription patterns and factors influencing the use of Chinese herbal medicine among pregnant women in Taiwan: A population-based retrospective study. BMC Complement Med Ther.,  2020, 20(1), 240.
 [http://dx.doi.org/10.1186/s12906-020-03032-0]

[31]
Jurgens, T.M. Potential toxicities of herbal therapies in the developing fetus. Birth Defects Res. B Dev. Reprod. Toxicol.,  2003, 68(6), 496-498.
 [http://dx.doi.org/10.1002/bdrb.10050] [PMID: 14745985]

[32]
Illamola, S.M.; Amaeze, O.U.; Krepkova, L.V.; Birnbaum, A.K.; Karanam, A.; Job, K.M.; Bortnikova, V.V.; Sherwin, C.M.T.; Enioutina, E.Y. Use of herbal medicine by pregnant women: What physicians need to know? Front. Pharmacol.,  2020, 10, 1483.
 [http://dx.doi.org/10.3389/fphar.2019.01483] [PMID: 31998122]

[33]
John, L.J.; Shantakumari, N. Herbal medicines use during pregnancy: A review from the Middle East. Oman Med. J.,  2015, 30(4), 229-236.
 [http://dx.doi.org/10.5001/omj.2015.48] [PMID: 26366255]

[34]
Bayan, L.; Koulivand, P.H.; Gorji, A. Garlic: A review of potential therapeutic effects. Avicenna J. Phytomed.,  2014, 4(1), 1-14.
 [PMID: 25050296]

[35]
Boschert, S. Ginger, vitamin B6 ease nausea in pregnancy. Fam. Pract. News,  2007, 37(23), 30.
 [http://dx.doi.org/10.1016/S0300-7073(07)71420-2]

[36]
Omidvar, S.; Firouzbakht, M.; Nikpour, M.; Jamali, B. Comparison of ginger with vitamin B6 in relieving nausea and vomiting during pregnancy. Ayu,  2014, 35(3), 289-293.
 [http://dx.doi.org/10.4103/0974-8520.153746] [PMID: 26664238]

[37]
Backon, J. Ginger as an antiemetic: Possible side effects due to its thromboxane synthetase activity. Anaesthesia,  1991, 46(8), 705-706.
 [http://dx.doi.org/10.1111/j.1365-2044.1991.tb09754.x] [PMID: 1888002]

[38]
Sivakumar, P.; Monisha, S.; Selvaraj, K.S.V.; Chitra, M.; Prabha, T.; Santhakuma, M.; Bharathi, A.; Velayutham, A. Nutritional value, phytochemistry, pharmacological and in vitro regeneration of turmeric (Curcuma longa L.): An updated review. Ann. Phytomed.,  2022, 11(1)
 [http://dx.doi.org/10.54085/ap.2022.11.1.23]

[39]
Filardi, T.; Varì, R.; Ferretti, E.; Zicari, A.; Morano, S.; Santangelo, C. Curcumin: Could this compound be useful in pregnancy and pregnancy-related complications? Nutrients,  2020, 12(10), 3179.
 [http://dx.doi.org/10.3390/nu12103179] [PMID: 33080891]

[40]
Oderinwale, O.A.; Oluwatosin, B.O.; Onagbesan, M.O.; Adekunle, E.O.; Shuaibu, A.Y.; Amosu, S.D.; Adeyemo, A.J.; Kuye, O.M.; Olalere, J.O.; Ajewole, I.T. Effects of dietary inclusion of turmeric (Curcuma longa L.) powder on oxidative stress and cortisol concentration in goats during pregnancy and onset of postpartum. Niger. J. Anim. Prod.,  2022, 48(6), 374-390.
 [http://dx.doi.org/10.51791/njap.v48i6.3325]

[41]
Tahvilzadeh, M.; Hajimahmoodi, M.; Rahimi, R. The role of date palm (Phoenix dactylifera L) Pollen in fertility. J. Evid. Based Complementary Altern. Med.,  2016, 21(4), 320-324.
 [http://dx.doi.org/10.1177/2156587215609851] [PMID: 26438718]

[42]
 Turmeric and Pregnancy: Beneficial Combo or Cause for Concern? 2019. Available From:
          https://www.healthline.com/health/pregnancy/turmeric-pregnancy

[43]
Silvestris, E.; Lovero, D.; Palmirotta, R. Nutrition and Female Fertility: An Interdependent Correlation. Front. Endocrinol.,  2019, 10, 346.
 [http://dx.doi.org/10.3389/fendo.2019.00346] [PMID: 31231310]

[44]
 Consuming walnuts during pregnancy - advantages, risks & more. 2021. Available From:
          https://parenting.firstcry.com/articles/benefits-risks-of-eating-walnuts-in-pregnancy/

[45]
Talcott, P. Toxicologic Problems.Equine Internal Medicine; Elsevier: Amsterdam, 2018, pp. 1460-1512.

[46]
 How to use castor oil to induce labor during pregnancy. 2020. Available From:
          https://parenting.firstcry.com/articles/castor-oil-during-pregnancy-for-labour-induction-is-it-really-safe/

[47]
Hussain, S.; Rehman, R.; Mushtaq, A.; El Zerey-Belaskri, A.  Clove: A review of a precious species with multiple uses. 2017. Available From:
          https://www.researchgate.net/publication/337821557_Clove_A_review_of_a_precious_species_with_multiple_uses

[48]
Simpson, M.; Parsons, M.; Greenwood, J.; Wade, K. Raspberry leaf in pregnancy: Its safety and efficacy in labor. J. Midwifery Womens Health,  2001, 46(2), 51-59.
 [http://dx.doi.org/10.1016/S1526-9523(01)00095-2] [PMID: 11370690]

[49]
Wirngo, F.E.; Lambert, M.N.; Jeppesen, P.B. The physiological effects of dandelion (Taraxacum Officinale) in Type 2 Diabetes. Rev. Diabet. Stud.,  2016, 13(2-3), 113-131.
 [http://dx.doi.org/10.1900/RDS.2016.13.113] [PMID: 28012278]

[50]
Taheri, Y.; Quispe, C.; Herrera-Bravo, J.; Sharifi-Rad, J.; Ezzat, S.M.; Merghany, R.M.; Shaheen, S.; Azmi, L.; Prakash Mishra, A.; Sener, B.; Kılıç, M.; Sen, S.; Acharya, K.; Nasiri, A.; Cruz-Martins, N.; Tsouh Fokou, P.V.; Ydyrys, A.; Bassygarayev, Z.; Daştan, S.D.; Alshehri, M.M.; Calina, D.; Cho, W.C. Urtica dioica-derived phytochemicals for pharmacological and therapeutic applications. Evid. Based Complement. Alternat. Med.,  2022, 2022, 1-30.
 [http://dx.doi.org/10.1155/2022/4024331] [PMID: 35251206]

[51]
Heitmann, K.; Nordeng, H.; Holst, L. Pregnancy outcome after use of cranberry in pregnancy – the Norwegian mother and child cohort study. BMC Complement. Altern. Med.,  2013, 13(1), 345.
 [http://dx.doi.org/10.1186/1472-6882-13-345] [PMID: 24314317]

[52]
 Contributors WE. Does chamomile tea induce labor? 2021. Available From:
          https://www.webmd.com/baby/does-chamomile-tea-induce-labor

[53]
Heitmann, K.; Havnen, G.C.; Holst, L.; Nordeng, H. Pregnancy outcomes after prenatal exposure to echinacea: The Norwegian Mother and Child Cohort Study. Eur. J. Clin. Pharmacol.,  2016, 72(5), 623-630.
 [http://dx.doi.org/10.1007/s00228-016-2021-5] [PMID: 26895223]

[54]
 Healthline. Raspberry leaf tea: Benefits and uses during pregnancy. 2020. Available From:
          https://utopia.org/guide/raspberry-leaf-tea-benefits-and-uses-during-pregnancy/

[55]
Singh, R.; De, S.; Belkheir, A. Avena sativa (Oat), a potential neutraceutical and therapeutic agent: An overview. Crit. Rev. Food Sci. Nutr.,  2013, 53(2), 126-144.
 [http://dx.doi.org/10.1080/10408398.2010.526725] [PMID: 23072529]

[56]
Roqaiya, M.; Begum, W.; Majeedi, S.F.; Saiyed, A. A review on herbs with uterotonic property. J. Pharmacol.,  2015, 4(3), 190-196.
 [http://dx.doi.org/10.31254/phyto.2015.4311]

[57]
Dove, D.; Johnson, P. Oral evening primrose oil: Its effect on length of pregnancy and selected intrapartum outcomes in low-risk nulliparous women. J. Nurse Midwifery,  1999, 44(3), 320-324.
 [http://dx.doi.org/10.1016/S0091-2182(99)00055-5] [PMID: 10380450]

[58]
Gray, R.; Brown, E. Castor oil for induction of labor in post-date pregnancies: Evidence of selective outcome reporting? Women Birth,  2021, 34(3)e334
 [http://dx.doi.org/10.1016/j.wombi.2020.12.011] [PMID: 33892910]

[59]
Jones, T.K.; Lawson, B.M. Profound neonatal congestive heart failure caused by maternal consumption of blue cohosh herbal medication. J. Pediatr.,  1998, 132(3), 550-552.
 [http://dx.doi.org/10.1016/S0022-3476(98)70041-1] [PMID: 9544922]

[60]
Enioutina, E.Y.; Salis, E.R.; Job, K.M.; Gubarev, M.I.; Krepkova, L.V.; Sherwin, C.M. Herbal Medicines: Challenges in the modern world. Part 5. status and current directions of complementary and alternative herbal medicine worldwide. Expert Rev. Clin. Pharmacol.,  2017, 10(3), 327-338.
 [PMID: 27923318]

[61]
 Laelago, T. Herbal medicine use during pregnancy: Benefits and untoward effects. 2018. Available From:
          www.intechopen.com/books/herbal-medicine/herbal-medicine-use-during-pregnancy-benefits-and-untoward-effects10.5772/intechopen.76896

[62]
Souza, M.R.; Brito, E.C.B.; Furtado, L.S.; Barco, V.S.; Cruz, L.L.; Moraes-Souza, R.Q.; Monteiro, G.C.; Lima, G.P.P.; Damasceno, D.C.; Volpato, G.T. Maternal-fetal toxicity of Strychnos pseudoquina extract treatment during pregnancy. J. Ethnopharmacol.,  2023, 311116459
 [http://dx.doi.org/10.1016/j.jep.2023.116459] [PMID: 37023837]

[63]
Dentali, S. Herbal integrity in research. Complement. Ther. Med.,  2022, 71(Oct)102895
 [http://dx.doi.org/10.1016/j.ctim.2022.102895] [PMID: 36273734]

[64]
Jo, J.; Lee, S.H.; Lee, J.M.; Lee, H.; Kwack, S.J.; Kim, D.I. Use and safety of Korean herbal medicine during pregnancy: A Korean medicine literature review. Eur. J. Integr. Med.,  2016, 8(1), 4-11.
 [http://dx.doi.org/10.1016/j.eujim.2015.10.008]

[65]
 Herb-Drug Interactions. 2021. Available From:
          https://www.nccih.nih.gov/health/providers/digest/herb-drug-interactions

[66]
Turkyilmaz, C. Effect of galactagogue herbal tea on breast milk production.Handbook of dietary and nutritional aspects of human breast milk; Zibadi, S.; Watson, R.R; Preedy, V.R., Ed.; Wageningen Academic Publishers: Wageningen, The Netherlands, 2013, pp. 615-630.
 [http://dx.doi.org/10.3920/978-90-8686-764-6_36]

[67]
Finkel, R.S.; Zarlengo, K.M. Blue cohosh and perinatal stroke. N. Engl. J. Med.,  2004, 351(3), 302-303.
 [http://dx.doi.org/10.1056/NEJM200407153510323] [PMID: 15254294]

[68]
McLay, J.S.; Izzati, N.; Pallivalapila, A.R.; Shetty, A.; Pande, B.; Rore, C.; Al Hail, M.; Stewart, D. Pregnancy, prescription medicines and the potential risk of herb-drug interactions: A cross-sectional survey. BMC Complement. Altern. Med.,  2017, 17(1), 543.
 [http://dx.doi.org/10.1186/s12906-017-2052-1] [PMID: 29258478]

[69]
Zamawe, C.; King, C.; Jennings, H.M.; Fottrell, E. Associations between the use of herbal medicines and adverse pregnancy outcomes in rural Malawi: A secondary analysis of randomised controlled trial data. BMC Complement. Altern. Med.,  2018, 18(1), 166.
 [http://dx.doi.org/10.1186/s12906-018-2203-z] [PMID: 29801482]

[70]
Izzo, A.A.; Ernst, E. Interactions between herbal medicines and prescribed drugs: A systematic review. Drugs,  2001, 61(15), 2163-2175.
 [http://dx.doi.org/10.2165/00003495-200161150-00002] [PMID: 11772128]

[71]
Ulbricht, C.; Basch, E.; Burke, D.; Cheung, L.; Ernst, E.; Giese, N.; Foppa, I.; Hammerness, P.; Hashmi, S.; Kuo, G.; Miranda, M.; Mukherjee, S.; Smith, M.; Sollars, D.; Tanguay-Colucci, S.; Vijayan, N.; Weissner, W. Fenugreek (Trigonella foenum-graecum L. Leguminosae): An evidence-based systematic review by the natural standard research collaboration. J. Herb. Pharmacother.,  2008, 7(3-4), 143-177.
 [http://dx.doi.org/10.1080/15228940802142852] [PMID: 18928139]

[72]
Kalava, A.; Darji, S.J.; Kalstein, A.; Yarmush, J.M. SchianodiCola, J.; Weinberg, J. Efficacy of ginger on intraoperative and postoperative nausea and vomiting in elective cesarean section patients. Eur. J. Obstet. Gynecol. Reprod. Biol.,  2013, 169(2), 184-188.
 [http://dx.doi.org/10.1016/j.ejogrb.2013.02.014] [PMID: 23510951]

[73]
Yang, J.B.; Li, W.F.; Liu, Y.; Wang, Q.; Cheng, X.L.; Wei, F.; Wang, A.G.; Jin, H.T.; Ma, S.C. Acute toxicity screening of different extractions, components and constituents of Polygonum multiflorum Thunb. on zebrafish (Danio rerio) embryos in vivo. Biomed. Pharmacother.,  2018, 99, 205-213.
 [http://dx.doi.org/10.1016/j.biopha.2018.01.033] [PMID: 29334663]

[74]
Chen, C.C.; Hsieh, M.S.; Hsuuw, Y.D.; Huang, F.J.; Chan, W.H. Hazardous effects of curcumin on mouse embryonic development through a mitochondria-dependent apoptotic signaling pathway. Int. J. Mol. Sci.,  2010, 11(8), 2839-2855.
 [http://dx.doi.org/10.3390/ijms11082839] [PMID: 21152277]

[75]
Rajagopal, R.E.; Balasubramanian, M.; Kalyanaraman, S. Raw turmeric and pure curcumin: A comparison of embryonic cytotoxicity in zebrafish. Int. J. Basic Clin. Pharmacol.,  2017, 6(8), 2020-2026.
 [http://dx.doi.org/10.18203/2319-2003.ijbcp20173290]

[76]
Ali, M.K.; Saber, S.P.; Taite, D.R.; Emadi, S.; Irving, R. The protective layer of zebrafish embryo changes continuously with advancing age of embryo development (AGED). J Toxicol Pharmacol,  2017, 1(2)

[77]
Alafiatayo, A.A.; Lai, K.S.; Syahida, A.; Mahmood, M.; Shaharuddin, N.A. Phytochemical evaluation, embryotoxicity, and teratogenic effects of Curcuma longa extract on Zebrafish (Danio rerio). Evid. Based Complement. Alternat. Med.,  2019, 2019, 1-10.
 [http://dx.doi.org/10.1155/2019/3807207] [PMID: 30949217]

[78]
Jayasinghe, C.D.; Jayawardena, U.A. Toxicity Assessment of herbal medicine using zebrafish embryos: A systematic review. Evid. Based Complement. Alternat. Med.,  2019, 2019, 1-17.
 [http://dx.doi.org/10.1155/2019/7272808] [PMID: 31781278]

[79]
 Maternal mortality: Evidence brief. 2022. Available From:
          https://www.who.int/publications/i/item/WHO-RHR-19.20

[80]
Laderman, C. symbolic and empirical reality: A new approach to the analysis of food avoidances. Am. Ethnol.,  1981, 8(3), 468-493.
 [http://dx.doi.org/10.1525/ae.1981.8.3.02a00040]

[81]
Katenga-Kaunda, L.Z.; Kamudoni, P.R.; Holmboe-Ottesen, G.; Fjeld, H.E.; Mdala, I.; Shi, Z.; Iversen, P.O. Enhancing nutrition knowledge and dietary diversity among rural pregnant women in Malawi: A randomized controlled trial. BMC Pregnancy Childbirth,  2021, 21(1), 644.
 [http://dx.doi.org/10.1186/s12884-021-04117-5] [PMID: 34551744]

[82]
Hepner, D.L.; Harnett, M.; Segal, S.; Camann, W.; Bader, A.M.; Tsen, L.C. Herbal medicine use in parturients. Anesth. Analg.,  2002, 94(3), 690-693.
 [http://dx.doi.org/10.1097/00000539-200203000-00039] [PMID: 11867399]

[83]
Tsui, B.; Dennehy, C.E.; Tsourounis, C. A survey of dietary supplement use during pregnancy at an academic medical center. Am. J. Obstet. Gynecol.,  2001, 185(2), 433-437.
 [http://dx.doi.org/10.1067/mob.2001.116688] [PMID: 11518905]

[84]
Gibson, PS; Powrie, R; Star, J Herbal and alternative medicine use during pregnancy: A cross-sectional survey. Obstet. Gynecol.,  2001, 97((4)(1)), S44-S45.
 [http://dx.doi.org/10.1097/00006250-200104001-00108]

[85]
Refuerzo, J.S.; Blackwell, S.C.; Sokol, R.J.; Lajeunesse, L.; Firchau, K.; Kruger, M.; Sorokin, Y. Use of over-the-counter medications and herbal remedies in pregnancy. Am. J. Perinatol.,  2005, 22(6), 321-324.
 [http://dx.doi.org/10.1055/s-2005-873235] [PMID: 16118721]

[86]
Maats, F.H.; Crowther, C.A. Patterns of vitamin, mineral and herbal supplement use prior to and during pregnancy. Australian &New Zealand J. Obstet. Gynaecol.,  2002, 42(5), 494-496.
 [http://dx.doi.org/10.1111/j.0004-8666.2002.00494.x] [PMID: 12495093]

[87]
Westfall, R.E. Use of anti-emetic herbs in pregnancy: Women’s choices, and the question of safety and efficacy. Complement. Ther. Nurs. Midwifery,  2004, 10(1), 30-36.
 [http://dx.doi.org/10.1016/S1353-6117(03)00057-X] [PMID: 14744504]

[88]
Hall, H.G.; Griffiths, D.L.; McKenna, L.G. The use of complementary and alternative medicine by pregnant women: A literature review. Midwifery,  2011, 27(6), 817-824.
 [http://dx.doi.org/10.1016/j.midw.2010.08.007] [PMID: 21247674]

[89]
Hall, H.; McKenna, L.; Griffiths, D. The future of maternity healthcare; midwives and complementary medicine. Integr. Med. Res.,  2015, 4(1), 25.
 [http://dx.doi.org/10.1016/j.imr.2015.04.346]

[90]
Adusi-Poku, Y.; Vanotoo, L.; Detoh, E.K.; Oduro, J.; Nsiah, R.B.; Natogmah, A.Z. Type of herbal medicines utilized by pregnant women attending ante-natal clinic in Offinso north district: Are orthodox prescribers aware? Ghana Med. J.,  2016, 49(4), 227.
 [http://dx.doi.org/10.4314/gmj.v49i4.2]

[91]
Maliwichi-Nyirenda, C.P.; Maliwichi, L.L.; Msosa, Y. The role of indigenous knowledge in the provision of health care in Malawi. Stud. Ethno-Med.,  2016, 10(4), 481-487.
 [http://dx.doi.org/10.1080/09735070.2016.11905521]

[92]
Abdollahi, F.; Khani, S.; Yazdani Charati, J. Prevalence and related factors to herbal medicines use among pregnant females. Jundishapur J. Nat. Pharm. Prod., 2018.
 [http://dx.doi.org/10.5812/jjnpp.13785]

[93]
Raoufinejad, K; Gholami, K; Javadi, M; Rajabi, M; Torkamandi, H; Moeini, A A retrospective cohort study of herbal medicines use during pregnancy: Prevalence, adverse reactions, and newborn outcomes. Trad Integr Med.,  2020, 5(2)

[94]
Nyeko, R.; Tumwesigye, N.M.; Halage, A.A. Prevalence and factors associated with use of herbal medicines during pregnancy among women attending postnatal clinics in Gulu district, Northern Uganda. BMC Pregnancy Childbirth,  2016, 16(1), 296.
 [http://dx.doi.org/10.1186/s12884-016-1095-5] [PMID: 27716105]

[95]
Dika, H.I.; Dismas, M.; Iddi, S.; Rumanyika, R. Prevalent use of herbs for reduction of labour duration in Mwanza, Tanzania: Are obstetricians aware? Tanzan. J. Health Res.,  2017, 19(2)
 [http://dx.doi.org/10.4314/thrb.v19i2.5]

[96]
Ong, C.O.; Chan, L.Y.; Yung, P.B.; Leung, T.N. Use of traditional Chinese herbal medicine during pregnancy: A prospective survey. Acta Obstet. Gynecol. Scand.,  2005, 84(7), 699-700.
 [http://dx.doi.org/10.1111/j.0001-6349.2005.00659.x] [PMID: 15954882]

[97]
Mugomeri, E.; Seliane, K.; Chatanga, P.; Maibvise, C. Identifying promoters and reasons for medicinal herb usage during pregnancy In Maseru, Lesotho. Afr. J. Nurs. Midwifery,  2015, 17(1), 4-16.
 [http://dx.doi.org/10.25159/2520-5293/63]

[98]
Panganai, T.; Shumba, P. The African Pitocin - a midwife’s dilemma: The perception of women on the use of herbs in pregnancy and labour in Zimbabwe, Gweru. Pan Afr. Med. J.,  2016, 25, 9.
 [http://dx.doi.org/10.11604/pamj.2016.25.9.7876] [PMID: 28203312]

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DOI https://dx.doi.org/10.2174/1573404820666230712125718	Print ISSN 1573-4048
Publisher Name Bentham Science Publisher	Online ISSN 1875-6581

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