Biochips for Detection of DNA Mutations

Title: Biochips for Detection of DNA Mutations

Volume: 2 Issue: 3

Author(s): Li-Jun Bi, Xian-En Zhang, Ya-Feng Zhou and Jiao-Yu Deng

Affiliation:

Keywords: DNA mutations, Genetic diseases, Drug resistance, Biochip, Detection

Abstract: DNA mutation is the major cause of gene evolution. The variation of DNA sequence may result in genetic diseases, genotypes, single nucleotide polymorphism, and drug resistance of pathogens. Using biochip technologies, detection of mutations can be performed in parallel under identical conditions, hereby providing a solution to continuously increasing demands for large-scale genetic analysis. This article reviews the development of the biochips for mutation analysis. Features, limitations and applications of various principles are discussed.

Cite this article as:

Bi Li-Jun, Zhang Xian-En, Zhou Ya-Feng and Deng Jiao-Yu, Biochips for Detection of DNA Mutations, Current Analytical Chemistry 2006; 2 (3) . https://dx.doi.org/10.2174/157341106777698242