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Current Traditional Medicine

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ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

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Review Article

Cardioprotective Activities of some Indian Spices: An Insight into Pharmacology and Phytochemical Investigation

Author(s): Kalyani Pathak*, Manash Pratim Pathak, Riya Saikia, Urvashee Gogoi, Jon Jyoti Sahariah, Aparoop Das, Mohammad Zaki Ahmad, Tirna Paul, Jyotirmoy Das and Saif Aboud M. Alqahtani

Volume 10, Issue 1, 2024

Published on: 09 March, 2023

Article ID: e100223213570 Pages: 15

DOI: 10.2174/2215083809666230210105442

Price: $65

Abstract

Cardiovascular disease (CVD) is the leading cause of death globally, and coronary heart disease (CHD) is the most prominent one among the spectrum of CVD. Conventional CHD drugs pose an increased risk of pharmaceutical interactions. Moreover, the possibility of tainting or substituting other medications also raises concerns. Diet and lifestyle play an important role in preventing and treating heart disease, and certain spices and supplements can help reduce the risk of heart disease and treat it. Spices have been an important part of Indian culture from the dawn of time, valued for both their culinary and medicinal virtues. Indian spices and their bioactive phytoconstituents are reported to play an ameliorating role in treating CHD. Despite the fact that the majority of these spices have an effect on organic components associated with the cardiovascular system, data on their therapeutic effects is sparse. To make the most of the enormous potential of these spices, multidisciplinary research is the need of the hour to establish them as remedies for CVDs. We endeavour to document some ethnopharmacological studies aimed to establish the cellular and molecular cardio-protective mechanisms of the spices and their bioactive phytoconstituents using recently reported in vitro and in vivo studies. Finally, we reviewed and reported the results of the recent clinical trials that have been conducted using these spices with special emphasis on their efficacy, safety, and toxicity.

Graphical Abstract

[1]
Sachan AK. Medicinal uses of spices used in our traditional culture: Worldwide. JMed Plants Stud 2018; 6(3): 116-22.
[2]
Benjamin EJ, Muntner P, Alonso A, et al. Heart disease and stroke Statistics-2019 update: A reportfrom the American Heart Association. Circulation 2019; 139(10): e56-e528.
[http://dx.doi.org/10.1161/CIR.0000000000000659] [PMID: 30700139]
[3]
Alzahrani T, Nguyen T, Ryan A, et al. Cardiovascular diseaseriskfactors and myocardial infarction in the transgender population. Circ Cardiovasc Qual Outcomes 2019; 12(4)e005597
[http://dx.doi.org/10.1161/CIRCOUTCOMES.119.005597] [PMID: 30950651]
[4]
Vasanthi HR, Parameswari RP. Indian spices for healthy heart - an overview. Curr Cardiol Rev 2010; 6(4): 274-9.
[http://dx.doi.org/10.2174/157340310793566172] [PMID: 22043203]
[5]
Sharangi AB, Guha S. Wonders of leafy spices: Medicinal properties ensuring Human Health. Sci Int 2013; 1(9): 312-7.
[http://dx.doi.org/10.17311/sciintl.2013.312.317]
[6]
Banerjee M, Sarkar PK. Microbiological quality of some retail spices in India. Food Res Int 2003; 36(5): 469-74.
[http://dx.doi.org/10.1016/S0963-9969(02)00194-1]
[7]
Gupta SC, Sung B, Kim JH, Prasad S, Li S, Aggarwal BB. Multitargeting by turmeric, the golden spice: From kitchen to clinic. Mol Nutr Food Res 2013; 57(9): 1510-28.
[http://dx.doi.org/10.1002/mnfr.201100741] [PMID: 22887802]
[8]
Platel K, Rao A, Saraswathi G, Srinivasan K. Digestive stimulant action of three Indian spice mixes in experimental rats. Nahrung 2002; 46(6): 394-8.
[http://dx.doi.org/10.1002/1521-3803(20021101)46:6<394:AID-FOOD394>3.0.CO;2-D] [PMID: 12577586]
[9]
Tajkarimi MM, Ibrahim SA, Cliver DO. Antimicrobial herb and spice compounds in food. Food Control 2010; 21(9): 1199-218.
[http://dx.doi.org/10.1016/j.foodcont.2010.02.003]
[10]
Ardekani EA. Memorial functional foods: A new concept from Bavi tribe. JEthn Foods 2020; 7(1): 1-10.
[11]
Sharma I, Gusain D, Dixit VP. Hypolipidaemic and antiatherosclerotic effects of Zingiber officinale in cholesterol fed rabbits. Phytother Res 1996; 10(6): 517-8.
[http://dx.doi.org/10.1002/(SICI)1099-1573(199609)10:6<517:AID-PTR839>3.0.CO;2-L]
[12]
Teli AB, Deori R, Saikia SP, et al. β -Thalassaemia and its co-existence with haemoglobin e and haemoglobin s in upper assam region of north eastern india: a hospital based study. J Clin Diagn Res 2016; 10(4): GC01-4.
[http://dx.doi.org/10.7860/JCDR/2016/16265.7675] [PMID: 27190829]
[13]
Bansilal S, Bonaca MP, Cornel JH, et al. Ticagrelor for secondary prevention of atherothrombotic events in patients with multivessel coronary disease. J Am Coll Cardiol 2018; 71(5): 489-96.
[http://dx.doi.org/10.1016/j.jacc.2017.11.050] [PMID: 29406853]
[14]
Cervellin G, Mattiuzzi C, Bovo C, Lippi G. Diagnostic algorithms for acute coronary syndrome-is one better than another? Ann Transl Med 2016; 4(10): 193.
[http://dx.doi.org/10.21037/atm.2016.05.16] [PMID: 27294089]
[15]
Pathak K, Das A, Shakya A, Saikia R, Sarma H. Evaluation of anti-diabetic and anti-hyperlipidemic activity of isolated bioactive compounds of leaves of Annona reticulata Linn. Nat Prod J 2021; 11(3): 414-21.
[http://dx.doi.org/10.2174/2210315510999200511132940]
[16]
Horton R. Offline: Chronic diseases-the social justice issue of our time. Lancet 2015; 386(10011): 2378.
[http://dx.doi.org/10.1016/S0140-6736(15)01178-2]
[17]
Lippi G, Sanchis-Gomar F, Cervellin G. Chest pain, dyspnea and other symptoms in patients with type 1 and 2 myocardial infarction. A literature review. Int J Cardiol 2016; 215: 20-2.
[http://dx.doi.org/10.1016/j.ijcard.2016.04.045] [PMID: 27107538]
[18]
Lloyd-Jones D, Adams RJ, Brown TM, et al. Executive summary: heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation 2010; 121(7): 948-54.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.109.192666] [PMID: 20177011]
[19]
Gupta M. Pharmacological properties and traditional therapeutic uses of important Indian spices: A review. Int J Food Prop 2010; 13(5): 1092-116.
[http://dx.doi.org/10.1080/10942910902963271]
[20]
Sharif MK. Nutritional and therapeuticpotential of spices Ther Probiotic Unconv Foods. Academic Press 2018; pp. 181-99.
[21]
Singh G. Antioxidant andantimicrobialactivitiesofessentialoiland-variousoleoresins Ofelettaria cardamomum (seedsandpods). J Sci Food Agric 2008; 88(2): 280-9.
[http://dx.doi.org/10.1002/jsfa.3087]
[22]
Rezooqe NS. Antifungal efficiency of miswak & cardamom extract on some virulence factors of Candida albicans as oral pathogen. Biol JKufa Uni 2011; 3: 297-303.
[23]
Asimi OA, Sahu NP. Effect of antioxidant rich spices, clove and cardamom extracts on the metabolic enzyme activity of Labeo Rohita. JFishLivestProd 2016; 04(01): 1-6.
[24]
Nigam SS, Purohit RM. Chemical examination of the essential oil derived from the seeds of Amomum subulatum Roxb. Perfum Essent Oil Rec 1960; 51: 121-3.
[25]
Mukherjee PK, Maiti K, Mukherjee K, Houghton PJ. Leads from Indian medicinal plants with hypoglycemic potentials. J Ethnopharmacol 2006; 106(1): 1-28.
[http://dx.doi.org/10.1016/j.jep.2006.03.021] [PMID: 16678368]
[26]
Goyal S, Sharma C, Mahajan U, et al. Protective effects of cardamom in isoproterenol-induced myocardialinfarction in rats. Int J Mol Sci 2015; 16(11): 27457-69.
[http://dx.doi.org/10.3390/ijms161126040] [PMID: 26593900]
[27]
Verma SK, Jain V, Katewa SS. Blood pressure lowering, fibrinolysis enhancing and antioxidant activities of cardamom (Elettaria cardamomum). Indian J Biochem Biophys 2009; 46(6): 503-6.
[PMID: 20361714]
[28]
Shahidullah M. Evaluation of cardioprotectiveactivity of macerationextract of Elettaria cardamomum in doxorubicininducedcardiotoxicity in rats. Indian J Res Pharm Biotechnol 2017; 5(6): 366-70.
[29]
Kumar S, Kumari R. Traditional phytochemical and biological activities of Elettaria cardamomum (L.) Maton - A review. Int J Pharm Sci Res 2021; 12(8): 4122-31.
[30]
Rao PV, Gan SH. Cinnamon: a multifaceted medicinal plant. Evid Based Complement Alternat Med 2014; 2014: 1-12.
[http://dx.doi.org/10.1155/2014/642942] [PMID: 24817901]
[31]
Ghosh T. Antioxidant activity and structuralfeatures of Cinnamomum Zeylanicum. 3 Biotech 2015; 5: 939-47.
[http://dx.doi.org/10.1007/s13205-015-0296-3]
[32]
Ranasinghe P, Galappaththy P. health benefits of ceylon cinnamon (cinnamomum zeylanicum): a summary of the current evidence. Ceylon Med J 2016; 61(1): 1-5.
[33]
Sandamali JAN, Hewawasam RP, Jayatilaka KAPW, Mudduwa LKB. Cinnamomum zeylanicum Blume (Ceylon cinnamon) bark extract attenuates doxorubicin induced cardiotoxicity in Wistar rats. Saudi Pharm J 2021; 29(8): 820-32.
[http://dx.doi.org/10.1016/j.jsps.2021.06.004] [PMID: 34408544]
[34]
Sedighi M, Nazari A, Faghihi M, et al. Protective effects of cinnamon bark extract against ischemia-reperfusion injury and arrhythmias in rat. Phytother Res 2018; 32(10): 1983-91.
[http://dx.doi.org/10.1002/ptr.6127] [PMID: 29917280]
[35]
Gruenwald J, Freder J, Armbruester N. Cinnamon and Health. Crit Rev Food Sci Nutr 2010; 50(9): 822-34.
[http://dx.doi.org/10.1080/10408390902773052] [PMID: 20924865]
[36]
Zhou L. Effect of Wu Lin Powder and its ingredients on atrial natriuretic factor level in mice. J Integr Tradit West Med 1995; 15(1): 36-7.
[37]
Nagababu E, Lakshmaiah N. Inhibitory effect of eugenol on non-enzymatic lipid peroxidation in rat liver mitochondria. Biochem Pharmacol 1992; 43(11): 2393-400.
[http://dx.doi.org/10.1016/0006-2952(92)90318-D] [PMID: 1319160]
[38]
Al-Okbi SY, Mohamed DA, Hamed TE, Edris AE. Protective effect of clove oil and eugenol microemulsions on fatty liver and dyslipidemia as components of metabolic syndrome. J Med Food 2014; 17(7): 764-71.
[http://dx.doi.org/10.1089/jmf.2013.0033] [PMID: 24611461]
[39]
Shukri R, Mohamed S, Mustapha NM. Cloves protect the heart, liver and lens of diabetic rats. Food Chem 2010; 122(4): 1116-21.
[http://dx.doi.org/10.1016/j.foodchem.2010.03.094]
[40]
Kamatou GP, Vermaak I, Viljoen AM. Eugenol-from the remote Maluku Islands to the international market place: a review of a remarkable and versatile molecule. Molecules 2012; 17(6): 6953-81.
[http://dx.doi.org/10.3390/molecules17066953] [PMID: 22728369]
[41]
Chaieb K. The chemicalcompositionandbiologicalactivityofclove essentialoil, Eugenia caryophyllata. Phytother Res 2007; 21(6): 501-6.
[http://dx.doi.org/10.1002/ptr.2124] [PMID: 17380552]
[42]
Yadav AS, Bhatnagar D. Free radical scavenging activity, metal chelation and antioxidant power of some of the Indian spices. Biofactors 2007; 31(3-4): 219-27.
[http://dx.doi.org/10.1002/biof.5520310309] [PMID: 18997285]
[43]
Grieve M. A Modern Herbal. (2nd ed.). New York: Hafner Publishing Company 2013; pp. 120-35.
[44]
Önder A. Coriander and Its Phytoconstituents for the Beneficial Effects. In: Potential Essent Oils. 2018.
[45]
Chobanian AV. Single risk factor intervention may be inadequate to inhibit atherosclerosis progression when hypertension and hypercholesterolemia coexist. Hypertension 1991; 18(2): 130-1.
[http://dx.doi.org/10.1161/01.HYP.18.2.130] [PMID: 1885221]
[46]
Patel D, Desai S, Gajaria T, Devkar R, Ramachandran AV. Coriandrum sativum L. seed extract mitigates lipotoxicity in RAW 264.7 cells and prevents atherogenic changes in rats. EXCLI J 2013; 12: 313-34.
[PMID: 26417232]
[47]
Ramadan MF. Coriander (Coriandrum sativum L.) seedoilimprovesplasmalipidprofile in ratsfed a dietcontainingcholesterol. Eur Food Res Technol 2008; 227(4): 1173-82.
[48]
Nour N. The role of senna and fennel in ameliorating cardiovascular disease India beti crats. Am J Pharm Heal Res 2017; 5(8): 48-55.
[49]
Akbarpour M. Effects of corianderseedsupplementary and aerobicexercise on some cardiovascular risk factors in overweight women with type 2 diabetes. Iran JAromat Plants Res 2020; 36(1): 59-71.
[50]
Gupta N, Porter TD. Garlic and garlic-derived compounds inhibit human squalene monooxygenase. J Nutr 2001; 131(6): 1662-7.
[http://dx.doi.org/10.1093/jn/131.6.1662] [PMID: 11385050]
[51]
Gebhardt R. Multiple inhibitory effects of garlic extracts on cholesterol biosynthesis in hepatocytes. Lipids 1993; 28(7): 613-9.
[http://dx.doi.org/10.1007/BF02536055] [PMID: 8394977]
[52]
Sendl A, Elbl G, Steinke B, Redl K, Breu W, Wagner H. Comparative pharmacological investigations of Allium ursinum and Allium sativum. Planta Med 1992; 58(1): 1-7.
[http://dx.doi.org/10.1055/s-2006-961378] [PMID: 1620734]
[53]
Qi R, Liao F, Inoue K, Yatomi Y, Sato K, Ozaki Y. Inhibition by diallyl trisulfide, a garlic component, of intracellular Ca2+ mobilization without affecting inositol-1,4,5-trisphosphate (IP3) formation in activated platelets. Biochem Pharmacol 2000; 60(10): 1475-83.
[http://dx.doi.org/10.1016/S0006-2952(00)00467-6] [PMID: 11020449]
[54]
Kim-Park S, Ku DD. Garlic elicits a nitric oxide-dependent relaxation and inhibits hypoxic pulmonary vasoconstriction in rats. Clin Exp Pharmacol Physiol 2000; 27(10): 780-6.
[http://dx.doi.org/10.1046/j.1440-1681.2000.03333.x] [PMID: 11022969]
[55]
Li G. A clinical investigation on garlicin injectio for treatment of unstable angina pectoris and its actions on plasma endothelin and blood sugar levels. JTradChinMed 2000; 20(4): 243-6.
[56]
Breithaupt-Grögler K, Ling M, Boudoulas H, Belz GG. Protective effect of chronic garlic intake on elastic properties of aorta in the elderly. Circulation 1997; 96(8): 2649-55.
[http://dx.doi.org/10.1161/01.CIR.96.8.2649] [PMID: 9355906]
[57]
Jung F, Jung EM, Mrowietz C, Kiesewetter H, Wenzel E. Influence of garlic powder on cutaneous microcirculation: a randomised, placebo-controlled, double-blind, crossover study in apparently healthy subjects. Br J Clin Pract Suppl 1990; 69: 30-5.
[PMID: 2083171]
[58]
Ojulari LS, Olatubosun OT, Okesina KB, Owoyele BV. The effect of Zingiber officinale (Ginger) extract on blood pressure and heartrate in healthyhumans. IOSR J Dent Med Sci 2014; 13(10): 76-8.
[http://dx.doi.org/10.9790/0853-131037678] [http://dx.doi.org/10.9790/0853-131037678]
[59]
Ilkhanizadeh B, Shirpoor A, Khadem AM, Nemati S, Rasmi Y. Protective effects of ginger (Zingiber officinale) extract against diabetes-inducedheartabnormality in rats. Diabetes Metab J 2016; 40(1): 46-53.
[http://dx.doi.org/10.4093/dmj.2016.40.1.46] [PMID: 26912155]
[60]
Elseweidy MM, Abdallah FR, Younis NN, Aldohmy S, Kassem HM. 10-Dehydrogingerdione raises HDL-cholesterol through a CETP inhibition and wards off oxidation and inflammation in dyslipidemic rabbits. Atherosclerosis 2013; 231(2): 334-40.
[http://dx.doi.org/10.1016/j.atherosclerosis.2013.09.024] [PMID: 24267247]
[61]
El-Bassossy HM, Elberry AA, Ghareib SA, Azhar A, Banjar ZM, Watson ML. Cardioprotection by 6-gingerol in diabetic rats. Biochem Biophys Res Commun 2016; 477(4): 908-14.
[http://dx.doi.org/10.1016/j.bbrc.2016.06.157] [PMID: 27378426]
[62]
Gupta NN. Effect of onion on serumcholesterol, bloodcoagulationfactors and fibrinolyticactivity in alimentarylipemia. Indian J Med Res 1966; 54: 48-53.
[63]
Kalus U, Pindur G, Jung F, et al. Influence of the onion as an essential ingredient of the Mediterranean diet on arterial blood pressure and blood fluidity. Arzneimittelforschung 2000; 50(9): 795-801.
[PMID: 11050695]
[64]
Brankovic S, Radenkovic M, Kitic D, et al. Comparison of the hypotensive and bradycardic activity of ginkgo, garlic, and onion extracts. Clin Exp Hypertens 2011; 33(2): 95-9.
[http://dx.doi.org/10.3109/10641963.2010.531833] [PMID: 21269057]
[65]
McKay DL, Blumberg JB. A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.). Phytother Res 2006; 20(8): 619-33.
[http://dx.doi.org/10.1002/ptr.1936] [PMID: 16767798]
[66]
Sun J, Yang T, Wang P, et al. Activation of cold-sensing transient receptor potential melastatin subtype 8 antagonizes vasoconstriction and hypertension through attenuating RhoA/Rho kinase pathway. Hypertension 2014; 63(6): 1354-63.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.02573] [PMID: 24637663]
[67]
Osman NN. Impact of peppermint and thyme in amelioratingcardiac and hepatic disorders induced by feeding rats repeatedly heated fried oil. Int J Pharm Phytopharmacol Res 2019; 9(6): 10-20.
[68]
Kocaadam B, Şanlier N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit Rev Food Sci Nutr 2017; 57(13): 2889-95.
[http://dx.doi.org/10.1080/10408398.2015.1077195] [PMID: 26528921]
[69]
Hadi A, Pourmasoumi M, Ghaedi E, Sahebkar A. The effect of curcumin/turmeric on blood pressure modulation: A systematic review and meta-analysis. Pharmacol Res 2019; 150104505
[http://dx.doi.org/10.1016/j.phrs.2019.104505] [PMID: 31647981]
[70]
Qin S. Efficacy and safety of turmeric and curcumin in loweringbloodlipidlevels in patients with cardio vascular risk factors:] A meta-analysis of randomizedcontrolledtrials. Nutr J 2017; 16(1): 1-10.
[PMID: 28077138]
[71]
Srivastava R, Dikshit M, Srimal RC, Dhawan BN. Anti-thrombotic effect of curcumin. Thromb Res 1985; 40(3): 413-7.
[http://dx.doi.org/10.1016/0049-3848(85)90276-2] [PMID: 4082116]
[72]
Morimoto T, Sunagawa Y, Kawamura T, et al. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. J Clin Invest 2008; 118(3): 868-78.
[http://dx.doi.org/10.1172/JCI33160] [PMID: 18292809]
[73]
Nakmareong S, Kukongviriyapan U, Pakdeechote P, et al. Antioxidant and vascular protective effects of curcumin and tetrahydrocurcumin in rats with l-NAME-induced hypertension. Naunyn Schmiedebergs Arch Pharmacol 2011; 383(5): 519-29.
[http://dx.doi.org/10.1007/s00210-011-0624-z] [PMID: 21448566]
[74]
Rajakrishnan V. Role of curcumin in alcoholic hepatotoxicity. Med Sci Res 1998; 26: 715-9.
[75]
Kalpana C, Menon VP. Protective effect of curcumin on circulatory lipid peroxidation and antioxidant status during nicotine-induced toxicity. Toxicol Mech Methods 2004; 14(6): 339-43.
[http://dx.doi.org/10.1080/15376520490434692] [PMID: 20021100]
[76]
Akila G, Rajakrishnan V. Effects of curcumin on lipid profile and lipid peroxidation status in experimental hepatic fibrosis. Hepatol Res 1998; 11(3): 147-57.
[http://dx.doi.org/10.1016/S1386-6346(98)00026-6]
[77]
Nagase H, Woessner JF Jr. Matrix metalloproteinases. J Biol Chem 1999; 274(31): 21491-4.
[http://dx.doi.org/10.1074/jbc.274.31.21491] [PMID: 10419448]
[78]
Pourbagher-Shahri AM, Farkhondeh T, Ashrafizadeh M, Talebi M, Samargahndian S. Curcumin and cardiovascular diseases: Focus on cellular targets and cascades. Biomed Pharmacother 2021; 136(111214)111214
[http://dx.doi.org/10.1016/j.biopha.2020.111214] [PMID: 33450488]
[79]
Venkatesan N. Curcumin attenuation of acute adriamycin myocardial toxicity in rats. Br J Pharmacol 1998; 124(3): 425-7.
[http://dx.doi.org/10.1038/sj.bjp.0701877] [PMID: 9647462]
[80]
Daosukho C, Chen Y, Noel T, et al. Phenylbutyrate, a histone deacetylase inhibitor, protects against Adriamycin-induced cardiac injury. Free Radic Biol Med 2007; 42(12): 1818-25.
[http://dx.doi.org/10.1016/j.freeradbiomed.2007.03.007] [PMID: 17512461]
[81]
Huei-Chen H, Tong-Rong J, Sheau-Farn Y. Inhibitory effect of curcumin, an anti-inflammatory agent, on vascular smooth muscle cell proliferation. Eur J Pharmacol 1992; 221(2-3): 381-4.
[http://dx.doi.org/10.1016/0014-2999(92)90727-L] [PMID: 1426014]
[82]
a) Ramírez-Boscá A, Soler A, Carrión MA, et al. An hydroalcoholic extract of Curcuma longa lowers the apo B/apo A ratio. Mech Ageing Dev 2000; 119(1-2): 41-7.
[http://dx.doi.org/10.1016/S0047-6374(00)00169-X] [PMID: 11040400];
b) Ramirez Boscá A, Soler A, Carrión-Gutiérrez MA, et al. An hydroalcoholic extract of Curcuma longa lowers the abnormally high values of human-plasma fibrinogen. Mech Ageing Dev 2000; 114(3): 207-10.
[http://dx.doi.org/10.1016/S0047-6374(00)00089-0] [PMID: 10802125]
[83]
Soni KB, Kuttan R. Effect of administration on oral curcumin serum peroxides and cholesterol levels in human volunteers. Indian J Physiol Pharmacol 1992; 36(4): 273-5.
[PMID: 1291482]
[84]
Ozeki M. The effects of eugenol on the nerve and muscle in crayfish. Comp Biochem Physiol C Comp Pharmacol 1975; 50(2): 183-91.
[PMID: 240639]
[85]
Brodin P, Røed A. Effects of eugenol on rat phrenic nerve and phrenic nerve-diaphragm preparations. Arch Oral Biol 1984; 29(8): 611-5.
[http://dx.doi.org/10.1016/0003-9969(84)90130-4] [PMID: 6591893]
[86]
Leal-Cardoso JH, Lahlou S, Coelho-de-Souza AN, et al. Inhibitory actions of eugenol on rat isolated ileum. Can J Physiol Pharmacol 2002; 80(9): 901-6.
[http://dx.doi.org/10.1139/y02-117] [PMID: 12430985]
[87]
Damiani CEN, Rossoni LV, Vassallo DV. Vasorelaxant effects of eugenol on rat thoracic aorta. Vascul Pharmacol 2003; 40(1): 59-66.
[http://dx.doi.org/10.1016/S1537-1891(02)00311-7] [PMID: 12646411]
[88]
Hiroaki N, Ryuji U, Kimiko K, Nozomi K, Tsuyako O, Kenji K. Mechanisms mediating the vasorelaxing action of eugenol, a pungent oil, on rabbit arterial tissue. Jpn J Pharmacol 1999; 79(3): 327-34.
[http://dx.doi.org/10.1254/jjp.79.327] [PMID: 10230861]
[89]
Criddle DN, Madeira SVF, de Moura RS. Endothelium-dependent and -independent vasodilator effects of eugenol in the rat mesenteric vascular bed. J Pharm Pharmacol 2010; 55(3): 359-65.
[http://dx.doi.org/10.1211/002235702694] [PMID: 12724042]
[90]
Lima CC, Criddle DN, Coelho-de-Souza AN, Monte FJQ, Jaffar M, Leal-Cardoso JH. Relaxant and antispasmodic actions of methyleugenol on guinea-pig isolated ileum. Planta Med 2000; 66(5): 408-11.
[http://dx.doi.org/10.1055/s-2000-8594] [PMID: 10909258]
[91]
Sensch O, Vierling W, Brandt W, Reiter M. Effects of inhibition of calcium and potassium currents in guinea-pig cardiac contraction: comparison of β-caryophyllene oxide, eugenol, and nifedipine. Br J Pharmacol 2000; 131(6): 1089-96.
[http://dx.doi.org/10.1038/sj.bjp.0703673] [PMID: 11082115]
[92]
Interaminense LFL, Jucá DM, Magalhães PJC, Leal-Cardoso JH, Duarte GP, Lahlou S. Pharmacological evidence of calcium-channel blockade by essential oil of Ocimum gratissimum and its main constituent, eugenol, in isolated aortic rings from DOCA-salt hypertensive rats. Fundam Clin Pharmacol 2007; 21(5): 497-506.
[http://dx.doi.org/10.1111/j.1472-8206.2007.00514.x] [PMID: 17868202]
[93]
Choudhary R, Mishra KP, Subramanyam C. Prevention of isoproterenol-induced cardiac hypertrophy by eugenol, an antioxidant. Indian J Clin Biochem 2006; 21(2): 107-13.
[http://dx.doi.org/10.1007/BF02912923] [PMID: 23105625]
[94]
Mohammadi Nejad S, Özgüneş H, Başaran N. Pharmacological and toxicological properties of eugenol. Turkish J Pharm Sci 2017; 14(2): 201-6.
[http://dx.doi.org/10.4274/tjps.62207] [PMID: 32454614]
[95]
Lichtenthaler HK, Schweiger J. Cell wall bound ferulic acid, the major substance of the blue-green fluorescence emission of plants. J Plant Physiol 1998; 152(2-3): 272-82.
[http://dx.doi.org/10.1016/S0176-1617(98)80142-9] [http://dx.doi.org/10.1016/S0176-1617(98)80142-9]
[96]
Koktate CK. Terpenoids. Pharmacognosy, 46th. NiraliPrakashan, Pune 2010; 2(1): 46.
[97]
Clifford MN. Chlorogenic acids and other cinnamates - nature, occurrence and dietary burden. J Sci Food Agric 1999; 79(3): 362-72.
[http://dx.doi.org/10.1002/(SICI)1097-0010(19990301)79:3<362:AID-JSFA256>3.0.CO;2-D]
[98]
Vogt T. Phenylpropanoid biosynthesis. Mol Plant 2010; 3(1): 2-20.
[http://dx.doi.org/10.1093/mp/ssp106] [PMID: 20035037]
[99]
Ferrer JL, Austin MB, Stewart C Jr, Noel JP. Structure and function of enzymes involved in the biosynthesis of phenylpropanoids. Plant Physiol Biochem 2008; 46(3): 356-70.
[http://dx.doi.org/10.1016/j.plaphy.2007.12.009] [PMID: 18272377]
[100]
Mnafgui K, Derbali A, Sayadi S, Gharsallah N, Elfeki A, Allouche N. Anti-obesity and cardioprotective effects of cinnamic acid in high fat diet- induced obese rats. J Food Sci Technol 2015; 52(7): 4369-77.
[http://dx.doi.org/10.1007/s13197-014-1488-2] [PMID: 26139902]
[101]
Abusarah J, Benabdoune H, Shi Q, et al. Elucidating the role of protandim and 6-gingerol in protection against osteoarthritis. J Cell Biochem 2017; 118(5): 1003-13.
[http://dx.doi.org/10.1002/jcb.25659] [PMID: 27463229]
[102]
Chakraborty D, Bishayee K, Ghosh S, Biswas R, Kumar Mandal S, Rahman Khuda-Bukhsh A. [6]-Gingerol induces caspase 3 dependent apoptosis and autophagy in cancer cells: Drug-DNA interaction and expression of certain signal genes in HeLa cells. Eur J Pharmacol 2012; 694(1-3): 20-9.
[http://dx.doi.org/10.1016/j.ejphar.2012.08.001] [PMID: 22939973]
[103]
Lee H, Seo E, Kang N, Kim W. [6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells. J Nutr Biochem 2008; 19(5): 313-9.
[http://dx.doi.org/10.1016/j.jnutbio.2007.05.008] [PMID: 17683926]
[104]
Srinivasan K, Sambaiah K. The effect of spices on cholesterol 7 alpha-hydroxylase activity and on serum and hepatic cholesterol levels in the rat. Int J Vitam Nutr Res 1991; 61(4): 364-9.
[PMID: 1806542]
[105]
Tanabe M, Chen YD, Saito K, Kano Y. Cholesterol biosynthesis inhibitory component from Zingiber officinale Roscoe. Chem Pharm Bull 1993; 41(4): 710-3.
[http://dx.doi.org/10.1248/cpb.41.710] [PMID: 8508473]
[106]
Marchese A, Barbieri R, Sanches-Silva A, et al. Antifungal and antibacterial activities of allicin: A review. Trends Food Sci Technol 2016; 52: 49-56.
[http://dx.doi.org/10.1016/j.tifs.2016.03.010]
[107]
Okada Y, Tanaka K, Fujita I, Sato E, Okajima H. Antiodidant activity of thiosulfinates derived from garlic. Redox Rep 2005; 10(2): 96-102.
[http://dx.doi.org/10.1179/135100005X38851] [PMID: 15949130]
[108]
Abramovitz D, Gavri S, Harats D, et al. Allicin-induced decrease in formation of fatty streaks (atherosclerosis) in mice fed a cholesterol-rich diet. Coron Artery Dis 1999; 10(7): 515-20.
[http://dx.doi.org/10.1097/00019501-199910000-00012] [PMID: 10562920]
[109]
Kleijnen J, Knipschild P, Riet G. Garlic, onions and cardiovascular risk factors. A review of the evidence from human experiments with emphasis on commercially available preparations. Br J Clin Pharmacol 1989; 28(5): 535-44.
[http://dx.doi.org/10.1111/j.1365-2125.1989.tb03539.x] [PMID: 2686739]
[110]
Yeh YY, Liu L. Cholesterol-lowering effect of garlic extracts and organosulfur compounds: human and animal studies. J Nutr 2001; 131(3): 989S-93S.
[http://dx.doi.org/10.1093/jn/131.3.989S] [PMID: 11238803]
[111]
Gebhardt R, Beck H. Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte cultures. Lipids 1996; 31(12): 1269-76.
[http://dx.doi.org/10.1007/BF02587912] [PMID: 8972460]
[112]
Li XQ, Liu XX, Wang XY, et al. Cinnamaldehyde derivatives inhibit coxsackievirus B3-induced viral myocarditis. Biomol Ther 2017; 25(3): 279-87.
[http://dx.doi.org/10.4062/biomolther.2016.070] [PMID: 27737525]
[113]
Song F, Li H, Sun J, Wang S. Protective effects of cinnamic acid and cinnamic aldehyde on isoproterenol-induced acute myocardial ischemia in rats. J Ethnopharmacol 2013; 150(1): 125-30.
[http://dx.doi.org/10.1016/j.jep.2013.08.019] [PMID: 24001892]
[114]
Hwa JS, Jin YC, Lee YS, et al. 2-Methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction. J Ethnopharmacol 2012; 139(2): 605-15.
[http://dx.doi.org/10.1016/j.jep.2011.12.001] [PMID: 22179023]
[115]
Xue YL, Shi HX, Murad F, Bian K. Vasodilatory effects of cinnamaldehyde and its mechanism of action in the rat aorta. Vasc Health Risk Manag 2011; 7: 273-80.
[http://dx.doi.org/10.2147/VHRM.S15429] [PMID: 21603596]
[116]
Anjoset PJ. Cardiovascular effects induced by linalool in normotensive and hypertensive rats. Z Naturforsch C J Biosci 2013; 68(5-6): 181-90.
[http://dx.doi.org/10.1515/znc-2013-5-603]
[117]
Kang P, Seol GH. Linalool elicits vasorelaxation of mouse aortae through activation of guanylyl cyclase and K+ channels. J Pharm Pharmacol 2015; 67(5): 714-9.
[http://dx.doi.org/10.1111/jphp.12359] [PMID: 25623816]
[118]
Camargo SB, Simões LO, Medeiros CFA, et al. Antihypertensive potential of linalool and linalool complexed with β-cyclodextrin: Effects of subchronic treatment on blood pressure and vascular reactivity. Biochem Pharmacol 2018; 151: 38-46.
[http://dx.doi.org/10.1016/j.bcp.2018.02.014] [PMID: 29454617]
[119]
Ravindranath V, Satyanarayana MN. An unsymmetrical diarylheptanoid from Curcuma longa. Phytochemistry 1980; 19(9): 2031-2.
[http://dx.doi.org/10.1016/0031-9422(80)83033-0]
[120]
Satyavati GV. Raina MK, Sharma MK Medicinal Plants of India. ICAR New Delhi 1976.
[121]
Gabrielsen A, Qiu H, Bäck M, et al. Thromboxane synthase expression and thromboxane A2 production in the atherosclerotic lesion. J Mol Med (Berl) 2010; 88(8): 795-806.
[http://dx.doi.org/10.1007/s00109-010-0621-6] [PMID: 20383787]
[122]
Tuso P, Stoll SR, Li WW. A plant-based diet, atherogenesis, and coronary artery disease prevention. Perm J 2015; 19(1): 62-7.
[http://dx.doi.org/10.7812/TPP/14-036] [PMID: 25431999]
[123]
Srivastava KC, Bordia A, Verma SK. Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets. Prostaglandins Leukot Essent Fatty Acids 1995; 52(4): 223-7.
[http://dx.doi.org/10.1016/0952-3278(95)90040-3] [PMID: 7784468]
[124]
Zhang L, Gu Z, Qin Z, Liang Z. Effect of curcumin on the adhesion of platelets to brain microvascular endothelial cells in vitro 1. Acta Pharmacol Sin 2008; 29(7): 800-7.
[http://dx.doi.org/10.1111/j.1745-7254.2008.00813.x] [PMID: 18565277]
[125]
Li X, Lu Y, Sun Y, Zhang Q. Effect of curcumin on permeability of coronary artery and expression of related proteins in rat coronary atherosclerosis heart disease model. Int J Clin Exp Pathol 2015; 8(6): 7247-53.
[PMID: 26261622]
[126]
Nicoll R, Henein MY. Ginger (Zingiber officinale Roscoe): A hot remedy for cardiovascular disease? Int J Cardiol 2009; 131(3): 408-9.
[http://dx.doi.org/10.1016/j.ijcard.2007.07.107] [PMID: 18037515]
[127]
Grzanna R, Lindmark L, Frondoza CG. Ginger-an herbal medicinal product with broad anti-inflammatory actions. J Med Food 2005; 8(2): 125-32.
[http://dx.doi.org/10.1089/jmf.2005.8.125] [PMID: 16117603]
[128]
Prasad S, Tyagi AK. Ginger and its constituents: role in prevention and treatment of gastrointestinal cancer. Gastroenterol Res Pract 2015; 2015(142979): 1-11.
[http://dx.doi.org/10.1155/2015/142979] [PMID: 25838819]
[129]
Ling J, Wei B, Lv G, Ji H, Li S. Anti-hyperlipidaemic and antioxidant effects of turmeric oil in hyperlipidaemic rats. Food Chem 2012; 130(2): 229-35.
[http://dx.doi.org/10.1016/j.foodchem.2011.07.039] [http://dx.doi.org/10.1016/j.foodchem.2011.07.039]
[130]
Elseweidy MM, Younis NN, Elswefy SE, et al. Atheroprotective potentials of curcuminoids against ginger extract in hypercholesterolaemic rabbits. Nat Prod Res 2015; 29(10): 961-5.
[http://dx.doi.org/10.1080/14786419.2014.957699] [PMID: 25208510]
[131]
Hosseini A, Hosseinzadeh H. A review on the effects of Allium sativum (Garlic) in metabolic syndrome. J Endocrinol Invest 2015; 38(11): 1147-57.
[http://dx.doi.org/10.1007/s40618-015-0313-8] [PMID: 26036599]
[132]
Om Kumar RV, Banerji A, Ramakrishna Kurup CK, Ramasarma T. The nature of inhibition of 3-hydroxy-3-methylglutaryl CoA reductase by garlic-derived diallyl disulfide. Biochim Biophys Acta Protein Struct Mol Enzymol 1991; 1078(2): 219-25.
[http://dx.doi.org/10.1016/0167-4838(91)90561-D] [PMID: 2065088]
[133]
Sobenin IA, Myasoedova VA, Iltchuk MI, Zhang DW, Orekhov AN. Therapeutic effects of garlic in cardiovascular atherosclerotic disease. Chin J Nat Med 2019; 17(10): 721-8.
[http://dx.doi.org/10.1016/S1875-5364(19)30088-3] [PMID: 31703752]
[134]
Shang A, Cao SY, Xu XY, et al. Bioactive compounds and biological functions of garlic (Allium sativum L.). Foods 2019; 8(7): 246.
[http://dx.doi.org/10.3390/foods8070246] [PMID: 31284512]
[135]
Gonen A, Harats D, Rabinkov A, et al. The antiatherogenic effect of allicin: possible mode of action. Pathobiology 2005; 72(6): 325-34.
[http://dx.doi.org/10.1159/000091330] [PMID: 16582584]
[136]
Satyal P, Setzer WN. Chemical compositions of commercial essential oils from Coriandrum sativum fruits and aerial parts Nat Prod Commun 2020; 15(7): 1934578X2093306. [doi:10.1177/1934578X20933067].
[http://dx.doi.org/10.1177/1934578X20933067]
[137]
Jun H, Lee JH, Kim J, et al. Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res 2014; 55(6): 1098-110.
[http://dx.doi.org/10.1194/jlr.M045807] [PMID: 24752549]
[138]
Blumenthal M, Busse WR, Goldberg A, et al. The Complete German Commission E Monographs Therapeutic Guide to Herbal Medicines. Austin, TX: American Botanical Council 1998.
[139]
Frishman WH, Sinatra ST, Moizuddin M. The use of herbs for treating cardiovascular disease. Seminars in Integrative Medicine 2004; 1(2): 23-35.
[http://dx.doi.org/10.1016/j.sigm.2004.05.002] [http://dx.doi.org/10.1016/j.sigm.2004.05.002]
[140]
Muthulakshmi V. Functional foods for chronicdiseases. D & A Inc/FF publishing 2009; 4: pp. 274-317.
[141]
Stavric B. Role of chemopreventers in human diet. Clin Biochem 1994; 27(5): 319-32.
[http://dx.doi.org/10.1016/0009-9120(94)00039-5] [PMID: 7867212]
[142]
Rahman K. Historical perspective on garlic and cardiovascular disease. J Nutr 2001; 131(3): 977S-9S.
[http://dx.doi.org/10.1093/jn/131.3.977S] [PMID: 11238800]
[143]
Fenwick GR, Hanley AB, Whitaker JR. The genus allium-part 1. CRC Crit Rev Food Sci Nutr 1985; 22(3): 199-271.
[http://dx.doi.org/10.1080/10408398509527415] [PMID: 3902370]
[144]
Pathak MP, Pathak K, Saikia R, et al. Immunomodulatory effect of mushrooms and their bioactive compounds in cancer: A comprehensive review. Biomed Pharmacother 2022; 149112901
[http://dx.doi.org/10.1016/j.biopha.2022.112901] [PMID: 36068771]
[145]
Rahman K, Lowe GM. Garlic and cardiovascular disease: a critical review. J Nutr 2006; 136(3) (Suppl.): 736S-40S.
[http://dx.doi.org/10.1093/jn/136.3.736S] [PMID: 16484553]
[146]
Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol 2007; 595: 1-75.
[http://dx.doi.org/10.1007/978-0-387-46401-5_1] [PMID: 17569205]
[147]
Krishnaswamy K. Turmeric-the Salt of the Orient Is the Spice of Life. New Delhi, India: Allied Publishers Pvt, Ltd. 2006.
[148]
Asolkar LV. Glossary of Indian Medicinal Plants; Publication and Information Directorate. New Delhi: CSI 1986.
[149]
Afzal M, Al-Hadidi D, Menon M, Pesek J, Dhami MSI. Ginger: an ethnomedical, chemical and pharmacological review. Drug Metabol Drug Interact 2001; 18(3-4): 159-90.
[http://dx.doi.org/10.1515/DMDI.2001.18.3-4.159] [PMID: 11791883]
[150]
Bordia A, Verma SK, Srivastava KC. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids 1997; 56(5): 379-84.
[http://dx.doi.org/10.1016/S0952-3278(97)90587-1] [PMID: 9175175]
[151]
Bhandari U. kanojia R, Pillai KK. Effect of ethanolic extract of Zingiber officinale on dyslipidaemia in diabetic rats. J Ethnopharmacol 2005; 97(2): 227-30.
[http://dx.doi.org/10.1016/j.jep.2004.11.011] [PMID: 15707757]
[152]
Fuhrman B, Rosenblat M, Hayek T, Coleman R, Aviram M. Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic, apolipoprotein E-deficient mice. J Nutr 2000; 130(5): 1124-31.
[http://dx.doi.org/10.1093/jn/130.5.1124] [PMID: 10801908]

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