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Current Alzheimer Research

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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From Infection to Inoculation: Expanding the Microbial Hypothesis of Alzheimer’s Disease

Author(s): Jolanta Dorszewska*, Mikołaj Hurła, Natalia Banaszek, Dominik Kobylarek, Thomas Piekut and Wojciech Kozubski

Volume 19, Issue 13, 2022

Published on: 13 February, 2023

Page: [849 - 853] Pages: 5

DOI: 10.2174/1567205020666230202155404

Price: $65

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[1]
Piekut T, Hurła M, Banaszek N, et al. Infectious agents and Alzheimer’s disease. J Integr Neurosci 2022; 21(2): 073.
[http://dx.doi.org/10.31083/j.jin2102073] [PMID: 35364661]
[2]
Bilello JA, Pitts OM, Hoffman PM. Characterization of a progressive neurodegenerative disease induced by a temperature-sensitive Moloney murine leukemia virus infection. J Virol 1986; 59(2): 234-41.
[http://dx.doi.org/10.1128/jvi.59.2.234-241.1986] [PMID: 3735486]
[3]
Andersson T, Schultzberg M, Schwarcz R, Löve A, Wickman C, Kristensson K. NMDA-receptor antagonist prevents measles virus-induced neurodegeneration. Eur J Neurosci 1991; 3(1): 66-71.
[http://dx.doi.org/10.1111/j.1460-9568.1991.tb00812.x] [PMID: 12106270]
[4]
Kristensson K. Potential role of viruses in neurodegeneration. Mol Chem Neuropathol 1992; 16(1-2): 45-58.
[http://dx.doi.org/10.1007/BF03159960] [PMID: 1520406]
[5]
Leblanc P, Vorberg IM. Viruses in neurodegenerative diseases: More than just suspects in crimes. PLoS Pathog 2022; 18(8): e1010670.
[http://dx.doi.org/10.1371/journal.ppat.1010670] [PMID: 35925897]
[6]
Ding Q, Shults NV, Harris BT, Suzuki YJ. Angiotensin-converting enzyme 2 (ACE2) is upregulated in Alzheimer’s disease brain. bioRxiv 2020; 2020; 331157.
[http://dx.doi.org/10.1101/2020.10.08.331157]
[7]
Kehoe PG, Wong S, AL Mulhim N, Palmer LE, Miners JS. Angiotensin-converting enzyme 2 is reduced in Alzheimer’s disease in association with increasing amyloid-β and tau pathology. Alzheimers Res Ther 2016; 8(1): 50.
[http://dx.doi.org/10.1186/s13195-016-0217-7] [PMID: 27884212]
[8]
Song KH, Kim DM, Lee H, et al. Dynamics of viral load and anti-SARS-CoV-2 antibodies in patients with positive RT-PCR results after recovery from COVID-19. Korean J Intern Med 2021; 36(1): 11-4.
[http://dx.doi.org/10.3904/kjim.2020.325] [PMID: 32972123]
[9]
Prendecki M, Kowalska M, Ł agan-Jędrzejczyk U, et al. Genetic factors related to the immune system in subjects at risk of developing Alzheimer’s disease. J Integr Neurosci 2020; 19(2): 359-71.
[http://dx.doi.org/10.31083/j.jin.2020.02.110] [PMID: 32706201]
[10]
Ball MJ. Limbic predilection in Alzheimer dementia: is reactivated herpesvirus involved? Can J Neurol Sci 1982; 9(3): 303-6.
[http://dx.doi.org/10.1017/S0317167100044115] [PMID: 7116237]
[11]
Kwok MK, Schooling CM. Herpes simplex virus and Alzheimer’s disease: A mendelian randomization study. Neurobiol Aging 2021; 99: 101.e11-3.
[http://dx.doi.org/10.1016/j.neurobiolaging.2020.09.025] [PMID: 33139072]
[12]
Piacentini R, De Chiara G, Li Puma DD, et al. HSV-1 and Alzheimer’s disease: More than a hypothesis. Front Pharmacol 2014; 5: 97.
[http://dx.doi.org/10.3389/fphar.2014.00097] [PMID: 24847267]
[13]
Huang SY, Yang YX, Kuo K, et al. Herpesvirus infections and Alzheimer’s disease: A mendelian randomization study. Alzheimers Res Ther 2021; 13(1): 158.
[http://dx.doi.org/10.1186/s13195-021-00905-5] [PMID: 34560893]
[14]
Tiwari D, Singh VK, Baral B, et al. Indication of neurodegenerative cascade initiation by amyloid-like aggregate-forming EBV proteins and peptide in Alzheimer’s disease. ACS Chem Neurosci 2021; 12(20): 3957-67.
[http://dx.doi.org/10.1021/acschemneuro.1c00584] [PMID: 34609141]
[15]
Costa Sa AC, Madsen H, Brown JR. Shared molecular signatures across neurodegenerative diseases and herpes virus infections highlights potential mechanisms for maladaptive innate immune responses. Sci Rep 2019; 9(1): 8795.
[http://dx.doi.org/10.1038/s41598-019-45129-8] [PMID: 31217489]
[16]
Allnutt MA, Johnson K, Bennett DA, et al. Human herpesvirus 6 detection in Alzheimer’s disease cases and controls across multiple cohorts. Neuron 2020; 105(6): 1027-1035.e2.
[http://dx.doi.org/10.1016/j.neuron.2019.12.031] [PMID: 31983538]
[17]
Whiley L, Chappell KE, D’Hondt E, et al. Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer’s disease. Alzheimers Res Ther 2021; 13(1): 20.
[http://dx.doi.org/10.1186/s13195-020-00741-z] [PMID: 33422142]
[18]
Miklossy J. Alzheimer’s disease - a neurospirochetosis. Analysis of the evidence following Koch’s and Hill’s criteria. J Neuroinflammation 2011; 8(1): 90.
[http://dx.doi.org/10.1186/1742-2094-8-90] [PMID: 21816039]
[19]
Miklossy J. Historic evidence to support a causal relationship between spirochetal infections and Alzheimer’s disease. Front Aging Neurosci 2015; 7: 46.
[http://dx.doi.org/10.3389/fnagi.2015.00046] [PMID: 25932012]
[20]
Senejani AG, Maghsoudlou J, El-Zohiry D, et al. Borrelia burgdorferi co-localizing with amyloid markers in Alzheimer’s Ddisease brain tissues. J Alzheimers Dis 2022; 85(2): 889-903.
[http://dx.doi.org/10.3233/JAD-215398] [PMID: 34897095]
[21]
Little CS, Hammond CJ, MacIntyre A, Balin BJ, Appelt DM. Chlamydia pneumoniae induces Alzheimer-like amyloid plaques in brains of BALB/c mice. Neurobiol Aging 2004; 25(4): 419-29.
[http://dx.doi.org/10.1016/S0197-4580(03)00127-1] [PMID: 15013562]
[22]
Miklossy J, Kis A, Radenovic A, et al. Beta-amyloid deposition and Alzheimer’s type changes induced by Borrelia spirochetes. Neurobiol Aging 2006; 27(2): 228-36.
[http://dx.doi.org/10.1016/j.neurobiolaging.2005.01.018] [PMID: 15894409]
[23]
Jungbauer G, Stähli A, Zhu X, Auber Alberi L, Sculean A, Eick S. Periodontal microorganisms and Alzheimer disease – A causative relationship? Periodontol 2000 2022; 89(1): 59-82.
[http://dx.doi.org/10.1111/prd.12429] [PMID: 35244967]
[24]
Anvari D, Sharif M, Sarvi S, et al. Seroprevalence of Toxoplasma gondii infection in cancer patients: A systematic review and meta-analysis. Microb Pathog 2019; 129: 30-42.
[http://dx.doi.org/10.1016/j.micpath.2019.01.040] [PMID: 30708042]
[25]
Letenneur L, Pérès K, Fleury H, et al. Seropositivity to herpes simplex virus antibodies and risk of Alzheimer’s disease: a population-based cohort study. PLoS One 2008; 3(11): e3637.
[http://dx.doi.org/10.1371/journal.pone.0003637] [PMID: 18982063]
[26]
Itzhaki RF, Lin WR, Shang D, Wilcock GK, Faragher B, Jamieson GA. Herpes simplex virus type 1 in brain and risk of Alzheimer’s disease. Lancet 1997; 349(9047): 241-4.
[http://dx.doi.org/10.1016/S0140-6736(96)10149-5] [PMID: 9014911]
[27]
Carbone I, Lazzarotto T, Ianni M, et al. Herpes virus in Alzheimer’s disease: Relation to progression of the disease. Neurobiol Aging 2014; 35(1): 122-9.
[http://dx.doi.org/10.1016/j.neurobiolaging.2013.06.024] [PMID: 23916950]
[28]
Stebbins RC, Noppert GA, Yang YC, Dowd JB, Simanek A, Aiello AE. Association between immune response to cytomegalovirus and cognition in the health and retirement study. Am J Epidemiol 2021; 190(5): 786-97.
[http://dx.doi.org/10.1093/aje/kwaa238] [PMID: 33094810]
[29]
Nimgaonkar VL, Yolken RH, Wang T, et al. Temporal cognitive decline associated with exposure to infectious agents in a population-based, aging cohort. Alzheimer Dis Assoc Disord 2016; 30(3): 216-22.
[http://dx.doi.org/10.1097/WAD.0000000000000133] [PMID: 26710257]
[30]
Wu X, Yang H, He S, et al. Adult vaccination as a protective factor for dementia: a meta-analysis and systematic review of population-based observational studies. Front Immunol 2022; 13: 872542.
[http://dx.doi.org/10.3389/fimmu.2022.872542] [PMID: 35592323]
[31]
Yang HY, Chien WC, Chung CH, et al. Risk of dementia in patients with toxoplasmosis: a nationwide, population-based cohort study in Taiwan. Parasit Vectors 2021; 14(1): 435.
[http://dx.doi.org/10.1186/s13071-021-04928-7] [PMID: 34454590]
[32]
Bakrania P, Hall G, Bouter Y, et al. Discovery of a novel pseudo β-hairpin structure of N-truncated amyloid-β for use as a vaccine against Alzheimer’s disease. Mol Psychiatry 2022; 27(2): 840-8.
[http://dx.doi.org/10.1038/s41380-021-01385-7] [PMID: 34776512]
[33]
André P, Samieri C, Buisson C, et al. Lipopolysaccharide-binding protein, soluble CD14, and the long-term risk of Alzheimer’s disease: A nested case-control pilot study of older community dwellers from the three-city cohort. J Alzheimers Dis 2019; 71(3): 751-61.
[http://dx.doi.org/10.3233/JAD-190295] [PMID: 31450497]
[34]
Płóciennikowska A, Hromada-Judycka A, Borzęcka K, Kwiatko-wska K. Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling. Cell Mol Life Sci 2015; 72(3): 557-81.
[http://dx.doi.org/10.1007/s00018-014-1762-5] [PMID: 25332099]
[35]
Zamudio F, Loon AR, Smeltzer S, et al. TDP-43 mediated blood-brain barrier permeability and leukocyte infiltration promote neurodegeneration in a low-grade systemic inflammation mouse model. J Neuroinflammation 2020; 17(1): 283.
[http://dx.doi.org/10.1186/s12974-020-01952-9] [PMID: 32979923]
[36]
Wang Z, Liu X, Da Teng, et al. Development of chimeric peptides to facilitate the neutralisation of lipopolysaccharides during bactericidal targeting of multidrug-resistant Escherichia coli. Commun Biol 2020; 3(1): 41.
[http://dx.doi.org/10.1038/s42003-020-0761-3] [PMID: 31974490]
[37]
Tao QQ, Chen YC, Wu ZY. The role of CD2AP in the pathogenesis of Alzheimer’s disease. Aging Dis 2019; 10(4): 901-7.
[http://dx.doi.org/10.14336/AD.2018.1025] [PMID: 31440393]
[38]
Liu NK, Zhang YP, Titsworth WL, et al. A novel role of phospholipase A2 in mediating spinal cord secondary injury. Ann Neurol 2006; 59(4): 606-19.
[http://dx.doi.org/10.1002/ana.20798] [PMID: 16498630]
[39]
Liao YF, Wang BJ, Cheng HT, Kuo LH, Wolfe MS. Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway. J Biol Chem 2004; 279(47): 49523-32.
[http://dx.doi.org/10.1074/jbc.M402034200] [PMID: 15347683]
[40]
He Z, Yang Y, Xing Z, et al. Intraperitoneal injection of IFN-γ restores microglial autophagy, promotes amyloid-β clearance and improves cognition in APP/PS1 mice. Cell Death Dis 2020; 11(6): 440.
[http://dx.doi.org/10.1038/s41419-020-2644-4] [PMID: 32514180]

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