The Use of the Inhibitory Receptors for Modulating the Immune Responses

Title: The Use of the Inhibitory Receptors for Modulating the Immune Responses

Volume: 14 Issue: 26

Author(s): S. M. Henson, R. Macaulay, S. Kiani-Alikhan and A. N. Akbar

Affiliation:

Keywords: Inhibitory, T cell, CTLA-4, PD-1

Abstract: Inhibitory receptors of the CD28 family, CTLA-4 and PD-1 deliver negative signals that regulate the balance between T cell activation, tolerance, and immunopathology. Manipulation of these pathways has been utilized by pathogens and tumors to establish chronic infections or to promote tumor survival. In this review, we examine the role of CTLA-4 and PD-1 in regulating immune response and discuss their therapeutic potential during aging.

Cite this article as:

Henson M. S., Macaulay R., Kiani-Alikhan S. and Akbar N. A., The Use of the Inhibitory Receptors for Modulating the Immune Responses, Current Pharmaceutical Design 2008; 14 (26) . https://dx.doi.org/10.2174/138161208786264124