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Current Medical Imaging

Editor-in-Chief

ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Case Report

Pituitary Adenoma with Multiple Calcifications in a Child: A Rare Case Presentation

Author(s): Juan Wang, Xinyu Zhao and Wei Zhang*

Volume 19, Issue 14, 2023

Published on: 22 February, 2023

Article ID: e250123213131 Pages: 4

DOI: 10.2174/1573405619666230125112459

Price: $65

Abstract

Introduction: Pediatric pituitary adenomas are rare, resulting in a limited amount of literature on these patients. The incidence of calcification in adult patients with pituitary adenomas is only 0.2% to 8%, while the incidence of calcification in children has not been reported.

Case Report: In this paper, we report a 10-year-old girl with a calcified pituitary adenoma. Laboratory examination showed the growth hormone (GH) to be more than 50ug/L, and pituitary prolactin (PRL) was 27.42 ng/mL. Non-contrast-enhanced computed tomography (CT) scans indicated a large sellar occupation with multiple nodules of calcification. Subsequently, the patient underwent a transcranial resection. Histopathologic evaluation confirmed the diagnosis of pituitary adenoma with multiple calcifications.

Conclusion: Since the management and prognosis of adenomas with calcification from other occupations of the pituitary gland differ significantly, it is important to differentiate between the two.

Graphical Abstract

[1]
Tavakol S, Hasan A, Wedemeyer MA, et al. Calcified prolactinoma of the pituitary gland: Illustrative case reports highlighting medical versus surgical intervention. J Neurol Surg B Skull Base 2020; 81(1): 022-9.
[http://dx.doi.org/10.1055/s-0039-1677678] [PMID: 32021746]
[2]
Xia Z, Guo X, Zhou Q, et al. Somatotrophic adenoma in children younger than 14 years: clinical features and treatment of 22 cases at a large pituitary center. World Neurosurg 2018; 112: e561-8.
[http://dx.doi.org/10.1016/j.wneu.2018.01.087] [PMID: 29360584]
[3]
Krajewski KL, Rotermund R, Flitsch J. Pituitary adenomas in children and young adults. Childs Nerv Syst 2018; 34(9): 1691-6.
[http://dx.doi.org/10.1007/s00381-018-3853-3] [PMID: 29850940]
[4]
Chen J, Schmidt RE, Dahiya S. Pituitary adenoma in pediatric and adolescent populations. J Neuropathol Exp Neurol 2019; 78(7): 626-32.
[http://dx.doi.org/10.1093/jnen/nlz040] [PMID: 31115468]
[5]
Locatelli D, Veiceschi P, Castelnuovo P, et al. Transsphenoidal surgery for pituitary adenomas in pediatric patients: a multicentric retrospective study. Childs Nerv Syst 2019; 35(11): 2119-26.
[http://dx.doi.org/10.1007/s00381-019-04179-z] [PMID: 31079182]
[6]
Kinoshita Y, Tominaga A, Usui S, et al. Pituitary adenomas in childhood and adolescence with a focus on intratumoral hemorrhage. Pituitary 2014; 17(1): 1-6.
[http://dx.doi.org/10.1007/s11102-012-0456-y] [PMID: 23263833]
[7]
Khan Y, Malik N, Awan S I, et al. Pituitary adenoma with calcifications: A case report 2019; 11(8): e5542.
[8]
Ibrahim R, Kalhan A, Lammie A, Kotonya C, Nannapanenni R, Rees A. Dense calcification in a GH-secreting pituitary macroadenoma. Endocrinol Diabetes Metab Case Rep 2014; 2014: 130079.
[http://dx.doi.org/10.1530/EDM-13-0079] [PMID: 24683483]
[9]
Webster J, Peters JR, John R, et al. Pituitary stone: two cases of densely calcified thyrotrophin-secreting pituitary adenomas. Clin Endocrinol (Oxf) 1994; 40(1): 137-43.
[http://dx.doi.org/10.1111/j.1365-2265.1994.tb02456.x] [PMID: 8306473]
[10]
Ke C, Deng Z, Lei T. al. Pituitary denoma with ossification: a rare histological variant and review of literature. Neuropathology 2010; 30: 165-9.
[http://dx.doi.org/10.1111/j.1440-1789.2009.01052.x] [PMID: 19737358]
[11]
Palaoǧlu S, Bavbek M, Peker S, Önol B, Sungur A, Erbengi A. Ossified somatotropinoma. Surg Neurol 1994; 41(2): 143-6.
[http://dx.doi.org/10.1016/0090-3019(94)90112-0] [PMID: 8115952]
[12]
Kasliwal MK, Sharma BS. A rare case of pituitary adenoma with calcification: a case report. Turk Neurosurg 2008; 18(3): 232-5.
[PMID: 18814109]
[13]
Rilliet B, Mohr G, Robert F, Hardy J. Calcifications in pituitary adenomas. Surg Neurol 1981; 15(4): 249-55.
[http://dx.doi.org/10.1016/S0090-3019(81)80003-1] [PMID: 6264639]

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