Polyethylenimine In Medicinal Chemistry

Title: Polyethylenimine In Medicinal Chemistry

Volume: 15 Issue: 27

Author(s): Paola Vicennati, Antonella Giuliano, Giancarlo Ortaggi and Andrea Masotti

Affiliation:

Keywords: Polyethylenimine, polymer, DNA, transfection, gene therapy, drug delivery, medicinal chemistry, biomedical applications

Abstract: Polyethylenimine (PEI), an organic branched or linear polyamine polymer, has been successfully used in the past for DNA complexation and transfection in vitro and in vivo into several cell lines and tissues. PEI was also applied in different fields from gene therapy and several studies have emphasized the importance of this polymer in medicinal chemistry. In this brief critical review the uses and applications of this versatile polymeric molecule will be discussed.

Cite this article as:

Vicennati Paola, Giuliano Antonella, Ortaggi Giancarlo and Masotti Andrea, Polyethylenimine In Medicinal Chemistry, Current Medicinal Chemistry 2008; 15 (27) . https://dx.doi.org/10.2174/092986708786242778