An apolipoprotein e synthetic peptide targets lipid particles to lipoprotein receptors

Title:An apolipoprotein e synthetic peptide targets lipid particles to lipoprotein receptors

Volume: 7 Issue: 3

Author(s): P.G. Lokhov*, O.M. Ipatova, O.Yu. Abakumova, T.A. Tsvetkova and V.N. Prozorovskii

Affiliation:

• Institute of Biomedical Chemistry RAMS, 119832, Moscow, Pogodinskay st.IO

Abstract: An apolipoprotein E 139-158 synthetic peptide was tested for targeting lipid particles to lipoprotein receptors. It was shown that this peptide increases lipid particle binding followed by receptor-mediated endocytosis by cells. In addition, the peptide mediates both acute clearance of lipoproteins followed by the decrease of cholesterol level in a rat blood and acute uptake of liposomes by the tissues which have a high level expression of lipoprotein receptors.

Cite this article as:

Lokhov P.G.*, Ipatova O.M., Abakumova O.Yu., Tsvetkova T.A. and Prozorovskii V.N., An apolipoprotein e synthetic peptide targets lipid particles to lipoprotein receptors, Protein & Peptide Letters 2000; 7 (3) . https://dx.doi.org/10.2174/092986650703221206121855