Synthesis of alzheimer's B-amyloid peptide fragment (33-42) on a new chemically inert ps-bdodma support

Title:Synthesis of alzheimer's B-amyloid peptide fragment (33-42) on a new chemically inert ps-bdodma support

Volume: 7 Issue: 3

Author(s): M. Roice, K. S. Kumar and V. N. Rajasekharan Pillai

Affiliation:

Abstract: The (33-42) fragment of Alzheimer's 13-amyloid peptide (Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile­ Ala) [1] was synthesised on a 2% 1,4-butanediol dimethacrylate cross-linked polystyrene (PS-BDODMA) support. The new polymer support was prepared by aqueous free-radical suspension polymerisation of styrene and 1,4-butanediol dimethacrylate. The peptide was synthesised.using Boe-amino acids and cleaved· from the resin by trifluoroacetic acid (TFA) in high purity and yield. The crude peptide was purified by HPLC and characterized by amino acid analysis and MALDI TOF MS.

Cite this article as:

Roice M., Kumar K. S. and Pillai Rajasekharan V. N., Synthesis of alzheimer's B-amyloid peptide fragment (33-42) on a new chemically inert ps-bdodma support, Protein & Peptide Letters 2000; 7 (3) . https://dx.doi.org/10.2174/092986650703221206121558