Effect of chiral guest residue on the conformation of short peptide containing the GLY-DPG-GLY segment: a cd investigation

Title:Effect of chiral guest residue on the conformation of short peptide containing the GLY-DPG-GLY segment: a cd investigation

Volume: 7 Issue: 2

Author(s): Kalpana Bhargava*R. Balaji Rao

Affiliation:

• Department ofyhemistry, Banaras Hindu University, Varanasi (U.P.)-221 005, INDIA

Abstract: The Gly-Dpg-Gly segment (Dpg = a ,a-Dipropylglycine) has already been shown to adopt a fully extended conformation in solution as well as in solid state. In this paper we investigate the effect of chiral residues and the terminal aromatic groups on extended conformation in solution with a Gly-Dpg-Gly backbone. CD studies on these peptides indicate that a chiral L-Leu residue at the C-terminus leads to a type I'/11' P-tum structure while a L-Leu residue at the N-terminus leads to a type,I/11P-turn. In addition we demonstrate the role of aromatic residues in the enhancement of CD intensities in the far UV region.

Cite this article as:

Bhargava Kalpana*, Rao Balaji R., Effect of chiral guest residue on the conformation of short peptide containing the GLY-DPG-GLY segment: a cd investigation, Protein & Peptide Letters 2000; 7 (2) . https://dx.doi.org/10.2174/092986650702221206115432