Cytotoxicity and membrane perturbation associated with the myristylated n-terminal portion of hiv-1 gag protein

Title:Cytotoxicity and membrane perturbation associated with the myristylated n-terminal portion of hiv-1 gag protein

Volume: 7 Issue: 1

Author(s): C. C. Curtain and I. G. Macreadie*

Affiliation:

• Biomolecular Research Institute, 343 Royal Parade, Parkville, Victoria 3052, Australia

Abstract: The Gag and Nef proteins of human immunodeficiency type l (HIV-1) have conserved N-terminal sequences that appear essential for HIV-1 function. In view of the structural similarities a Gag peptide corresponding to myrGag2_22, was subjected to cytotoxicity tests employing recently developed cell assays. The Gag peptide displays a similar activity to Nef. The role of such sequences may be important in viral membrane association, viral biogenesis and transition of these proteins through the cellular membrane.

Cite this article as:

Curtain C. C. and Macreadie I. G.*, Cytotoxicity and membrane perturbation associated with the myristylated n-terminal portion of hiv-1 gag protein, Protein & Peptide Letters 2000; 7 (1) . https://dx.doi.org/10.2174/092986650701221205155142