Wolff rearrangement of Na-protected a-aminodiazoketones in presence of substituted phenol as a method for the synthesis of 2,4,5- trichlorophenyl esters of Fmoc-/ Boe-/ Z-P-homoamino acids

Title:Wolff rearrangement of Na-protected a-aminodiazoketones in presence of substituted phenol as a method for the synthesis of 2,4,5- trichlorophenyl esters of Fmoc-/ Boe-/ Z-P-homoamino acids

Volume: 7 Issue: 1

Author(s): Hosahuciya N. Gopi, Kuppanna Ananda and Vommina V. Suresh Babu*

Affiliation:

• Department of Studies in Chemistry, Central College, Bangalore University, Bangalore - 560 001, India

Abstract: Silver acetate catalyzed decomposition of the Na-protected a­ aminodiazoketones in the presence of 'substituted phenol' and triethylamine at - 1s0c lead to 2,4,S-trichlorophenyl esters of Fmoc-/Boc-/Z-J3-homoamino acids in good yield and purity. Thus the homologation of a-amino acids to 13-homoamino acids with concomitant active esters formation has been achieved by this method.

Cite this article as:

Gopi N. Hosahuciya, Ananda Kuppanna and Babu V. Suresh Vommina*, Wolff rearrangement of Na-protected a-aminodiazoketones in presence of substituted phenol as a method for the synthesis of 2,4,5- trichlorophenyl esters of Fmoc-/ Boe-/ Z-P-homoamino acids, Protein & Peptide Letters 2000; 7 (1) . https://dx.doi.org/10.2174/092986650701221205154613