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Current Traditional Medicine

Editor-in-Chief

ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

Review Article

Ethnopharmacology, Botanical Description and Phytochemistry of Premna barbata: An Unexplored Medicinal Plant Species from Lamiaceae Family

Author(s): Bhuwan C. Joshi*, Vijay Juyal, Archana N. Sah and Minky Mukhija

Volume 8, Issue 6, 2022

Published on: 11 August, 2022

Article ID: e180522204980 Pages: 7

DOI: 10.2174/2215083808666220518123907

Price: $65

Abstract

Objectives: Premna barbata Wall. ex Schauer; (Lamiaceae) is a deciduous shrub or tree known as Aganyo in folk language. The plant is widely used in treating various diseases traditionally, such as arthritic pain, dropsy, diarrhoea, fever, and herpes complex disease. However, comprehensive data on this medicinally important plant is not available in the literature. Therefore, this review aims to provide a detailed overview of the botanical description, ethnomedicinal use, phytochemistry, and pharmacological investigations of Premna barbata to provide a scientific consensus for future research investigations and to link its traditionally claimed use to scientifically proven results.

Methods: Information regarding the plant was gathered from electronic databases such as Science Direct, PubMed, Web of Science, Wiley Online Library, ACS, Springer, SciFinder, Taylor and Francis, Google Scholar, Scopus and Journal websites. The scientific name of the plant was validated using The Plant List and The International Plant Names Index.

Results: An exhaustive study of the accessible sources of Premna barbata confirmed its origin, distribution, and ethnomedicinal use. It has been used in the form of powders, juice, paste, and decoctions against various ailments. Phytochemical analysis revealed the presence of different phytoconstituents. Only antibacterial potential of the plant has been reported yet.

Conclusion: By performing the literature search, Premna barbata showcased its importance in folkloric medicine as well as in ayurvedic medicine. Moreover, the collected information from various trustworthy sources shows that the plant holds many hidden potentials and can, therefore, be studied extensively for its quality control, pharmacognosy, phytochemistry and pharmacological activity. Furthermore, in-depth studies are required to discover key features which can help in future research work. An effort is required to investigate this plant species, which is found distributed in most unexplored regions as well as it needs to be preserved as it’s on the verge of extinction.

Keywords: Premna barbata, traditional uses, phytochemistry, premnosidic acid, pharmacology, ethnopharmacology.

Graphical Abstract

[1]
Munir AA. A taxonomic revision of the genus Premna L. (Verbenaceae) in Australia. J Adel Bot Gard 1984; 7: 1-43.
[2]
Fischer E, Kadereit JW. The families and genera of vascular plants In: Kadereit JW, Ed Flowering plants dicotyledons lamiales (except acanthaceae including avicenniaceae) Berlin, Heidelberg: Springer 2004; pp. 167-275.
[3]
Olmstead R. A sypnotical classification of the Lamiales 2010. Available from: http://depts.washington.edu/phylo/classifications/Lamial-es.html (Accessed February 22, 2022).
[4]
Olmstead R. A sypnotical classification of the Lamiales Available from: https://depts.washington.edu/phylo/Classification.pdf (Accessed February 22, 2022).
[5]
Angiosperm Phylogeny Group. An update of the Angiosperm phylogeny group classification for the orders and families of flowering plants: APG III. Bot J Linn Soc 2009; 161(2): 105-21.
[http://dx.doi.org/10.1111/j.1095-8339.2009.00996.x]
[6]
Francis S, Gideon VA, Britto SJ, Dessy VJ. A review on two endemic species of genus Premna and their conservational importance. J Drug Deliv Ther 2019; 9(4-s): 666-9.
[http://dx.doi.org/10.22270/jddt.v9i4-s.3330]
[7]
Dianita R, Jantan I. Ethnomedicinal uses, phytochemistry and pharmacological aspects of the genus Premna: A review. Pharm Biol 2017; 55(1): 1715-39.
[http://dx.doi.org/10.1080/13880209.2017.1323225] [PMID: 28486830]
[8]
Negi SS. Discovering the Himalaya. New Delhi, India: Indus Publishing 2002; p. 279.
[9]
Thirumalai D, Paridhavi M, Gowtham M. A phytochemical review on Premna species. Int J Res Phytochem Pharmacol 2011; 1(4): 196-200.
[10]
Rajendran A, Daniel P. The Indian Verbenaceae-A taxonomic revision. Dehradun: Bishen Singh Mahendra Pal Singh 2002; pp. 341-86.
[11]
Tewari D. Ecopharmacognosy: With special reference to Indian himalayan region. Int J Pharm Sci Rev Res 2014; 28(2): 147-9.
[12]
Uprety Y, Poudel RC, Asselin H, Boon E. Plant biodiversity and ethnobotany inside the projected impact area of the Upper Seti Hydro-power Project. Environ Dev Sustain 2011; 13(3): 463-92.
[http://dx.doi.org/10.1007/s10668-010-9271-7]
[13]
Rekha K, Richa PK, Babu S, Rao M. A phytochemistry of the genus Premna: A review. Int J Pharm Chem Sci 2015; 4(3): 317-25.
[14]
India biodiversity portal Available from: https://indiabiodiversity. org/species/show/251219 (Accessed February 22, 2022).
[15]
Naithani BD. Flora of Chamoli New Delhi, India: BSI publication 1985; pp. 496-7.
[16]
Nadkarni KM. Indian Materia Medica. Bombay, India: Popular Prakashan Pvt. Ltd. 1954; p. 1009.
[17]
Kumar JA, Divya J. Traditional and ethnobotanical uses Premna barbata Wall. Ex Schauer in Kumaun and Garhwal Regions of Uttarak-hand, India & Other Western Himalayan Countries-A review. Int J Pharmacogn Phytochem Res 2017; 9(9): 1213-6.
[http://dx.doi.org/10.25258/phyto.v9i09.10308]
[18]
Chanotiya CS, Yadav AK, Singh AK. Leaf oil composition of Premna barbata Wall. ex. Sch. from Kumaon Region of Uttarakhand. J Essent Oil Res 2009; 21(1): 76-7.
[http://dx.doi.org/10.1080/10412905.2009.9700116]
[19]
Kumari P, Joshi GC, Tewari LM. Diversity and status of ethno-medicinal plants of Almora district in Uttarakhand, India. Int J Biodivers Conserv 2011; 3(7): 298-326.
[20]
Singh P, Attri BL. Survey on traditional uses of medicinal plants of Bageshwar Valley (Kumaun Himalaya) of Uttarakhand, India. Int J Conserv Sci 2014; 5(2): 223-34.
[21]
Negi S, Shukla V, Rawat M, Pant G, Nagatsu A. Premnosidic acid, a new iridoid glycoside from Premna barbata. ChemInform 2004; 43(50): 1805-6.
[http://dx.doi.org/10.1002/chin.200450151]
[22]
Tamta M, Kumar A, Shukla N, Negi D. Effects of crude extracts of Premna barbata Wall and Clerodendrum viscosum Vent.(Verbenaceae) on different pathogenic bacteria. Asian J Tradit Med 2012; 7(1): 1-7.
[23]
Kabra A, Kabra R, Baghel US. Premna species: A review. J Biol Chem Chron 2015; 1(1): 55-9.
[24]
Available from: The Plant List http://www.theplantlist.org/tpl1.1/search?q=Premna+Barbata (Accessed February 22, 2022).
[25]
International Plant Name Index Available from: https://www.ipni.org/?q=Premna%20barbata (Accessed February 22, 2022).
[26]
Quattrocchi U. CRC world dictionary of medicinal and poisonous plants: Common names, scientific names, eponyms, synonyms, and etymology (5 Volume Set). Boca Rotan Florida: Taylor & Francis Group 2012; p. 3073.
[27]
Manandhar NP. Medicinal Plant-Lore of Tamang Tribe of Kabhrepalanchok District, Nepal. Econ Bot 1991; 45(1): 58-71.
[http://dx.doi.org/10.1007/BF02860050]
[28]
Pande PC, Tiwari L, Pande HC. Ethnoveterinary plants of Uttaranchal- A review. Indian J Tradit Knowl 2007; 6(3): 444-58.
[29]
Tiwari JK, Ballabha R, Tiwari P. Diversity and present status of medicinal plants in and around Srinagar Hydroelectric Power Project in Garhwal Himalaya, India: Needs for conservation. Researcher 2010; 2(2): 50-60.
[30]
Raijal A. Surviving on knowledge. Ethanobotany of Chepang community from mid hills of Nepal. Ethnobot Res Appl 2011; 9: 181-215.
[31]
Joshi K. Floristic diversity and traditional uses of plant resources of Kali Gandaki watershed, Nepal. Int J Pharm life Sci 2011; 1(3): 86- 111.
[32]
Tiwari L, Rai N, Sharma RK, Pande C. Inventorization of commercially exploited herbal drugs of central Himalaya used in Ayurvedic, Unani, Siddha and homoeopathic formulations. Hippocratic J Unani Med 2012; 7(1): 109-43.
[33]
Singh AG. Medicinal plants as a source of Antipyretic agent in Terai region of Western Nepal. Int J Appl Sci Biotechnol 2013; 1(3): 118-26.
[http://dx.doi.org/10.3126/ijasbt.v1i3.8383]
[34]
Sharma BC. Ethnomedicinal plants used against skin diseases by indigenous population of Darjeeling Himalayas, India. Indian J Fundam Appl Life Sci 2013; 3(3): 299-303.
[35]
Singh AG, Hamal JP. Traditional phytotherapy of some Medicinal plants used by Tharu and Magar communities of western Nepal, against dermatological disorders. ScientificWorldJournal 2013; 11(11): 81-9.
[36]
Bhatia H, Sharma YP, Manhas RK, Kumar K. Ethnomedicinal plants used by the villagers of district Udhampur, J&K, India. J Ethnopharmacol 2014; 151(2): 1005-18.
[http://dx.doi.org/10.1016/j.jep.2013.12.017] [PMID: 24365639]
[37]
Nemkul CM, Shrestha I. Ethnobotany and in vitro antimicrobial study of selected medicinal plants used by Magar community in Dhaubadi VDC, Nawalparasi district, Nepal. J Nat Hist Mus 2018; 30: 141-7.
[http://dx.doi.org/10.3126/jnhm.v30i0.27543]
[38]
Kim YS, Shin DH. Volatile constituents from the leaves of Callicarpa japonica Thunb. and their antibacterial activities. J Agric Food Chem 2004; 52(4): 781-7.
[http://dx.doi.org/10.1021/jf034936d] [PMID: 14969531]
[39]
Yadav D, Masood N, Luqman S, Brindha P, Gupta MM. Antioxidant furofuran lignans from Premna integrifolia. Ind Crops Prod 2013; 41: 397-402.
[http://dx.doi.org/10.1016/j.indcrop.2012.04.044]
[40]
Wang C, Gong X, Bo A, et al. Iridoids: Research advances in their phytochemistry, biological activities, and pharmacokinetics. Molecules 2020; 25(2): 287.
[http://dx.doi.org/10.3390/molecules25020287] [PMID: 31936853]
[41]
Dinda B. Pharmacology of Iridoids; Pharmacology and Applications of Naturally Occurring Iridoids. Cham, Switzerland: Springer 2019; pp. 1-15.
[http://dx.doi.org/10.1007/978-3-030-05575-2]

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