Novel Drugs for Diabetes Also Have Dramatic Benefits on Hard Outcomes
of Heart and Kidney Disease

Jonathan   C.H.   Chan; Michael   C.Y.   Chan

doi:10.2174/1573403X18666220511114443

Abstract

Background: Diabetes is a major risk factor for developing cardiovascular disease. Patients with both diabetes and cardiovascular disease have even higher mortality. The convergence of cardiology and diabetology therapy is an important step in treating patients and advancing research.

Results: Major landmark trials and meta-analyses involving Sodium Glucose Cotransporter 2 inhibitors have shown dramatic clinical cardiorenal benefits in patients both with and without type 2 diabetes. In type 2 diabetes patients, Glucagon-like peptide-1 receptor agonists have been shown to improve major cardiac outcomes.

Conclusion: This hot topic of research and clinical use of glucose lowering drugs intersects the fields of cardiovascular, renal, and diabetic medicine. The numerous cardiorenal benefits have led to the rapid adoption in clinical guidelines of these glucose lowering drugs in patients with Type 2 diabetes, cardiovascular disease, or renal disease.

Keywords: Cardiovascular disease, diabetes, cardiovascular outcome trial, SGLT2 inhibitor, GLP-1 receptor agonist, cardiorenal protection, heart failure, chronic kidney disease.

Graphical Abstract

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DOI https://dx.doi.org/10.2174/1573403X18666220511114443	Print ISSN 1573-403X
Publisher Name Bentham Science Publisher	Online ISSN 1875-6557

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Novel Drugs for Diabetes Also Have Dramatic Benefits on Hard Outcomes of Heart and Kidney Disease

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