Targeting AMPK Signaling in the Liver: Implications for Obesity and
Type 2 Diabetes Mellitus

doi:10.2174/1389450123666220429082702
摘要

肥胖和2型糖尿病（T2DM）作为常见的代谢疾病，病理性特征是营养过剩和胰岛素抵抗（IR），随后导致葡萄糖和脂质代谢紊乱。肝脏是人体的主要代谢器官，整合激素和代谢信号以调节脂质和葡萄糖的合成以及它们向外周组织的运输，因此在肥胖和T2DM的发展中起着至关重要的作用。腺苷5'-单磷酸活化蛋白激酶（AMPK）是参与真核生物细胞和生物体代谢的中央调节剂，可激活产生ATP的过程并减少其消耗。此外，AMPK 还调节线粒体稳态并促进自噬，这两者都与 IR 的发病机制相关。因此，增加 AMPK 活性被认为是预防肥胖和 T2DM 的有希望的治疗策略。在这篇综述中，我们总结了肝脏AMPK在肥胖和T2DM中的作用以及使用AMPK激活剂治疗代谢紊乱的潜力。
关键词: 肥胖，2型糖尿病，肝脏，AMPK激活剂，高血糖症。
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图形摘要

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DOI https://dx.doi.org/10.2174/1389450123666220429082702	Print ISSN 1389-4501
Publisher Name Bentham Science Publisher	Online ISSN 1873-5592
当代药物靶点

靶向肝脏中的 AMPK 信号传导：对肥胖和 2 型糖尿病的影响

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当代药物靶点

靶向肝脏中的 AMPK 信号传导：对肥胖和 2 型糖尿病的影响

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