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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Review Article

Site-Specific Binding of Anti-Cancer Drugs to Human Serum Albumin

Author(s): Mrinalini Bhosale, Ishtiaq Jeelani*, Allah Nawaz, Hitoshi Abe and Subhash Padhye

Volume 22, Issue 16, 2022

Published on: 25 May, 2022

Page: [2876 - 2884] Pages: 9

DOI: 10.2174/1871520622666220324094033

Price: $65

Abstract

The interaction of drugs with proteins plays a very important role in the distribution of the drug. Human serum albumin (HSA) is the most abundant protein in the human body, showing great binding characteristics, and has gained a lot of importance pharmaceutically. It plays an essential role in the pharmacokinetics of a number of drugs; hence, several reports are available on the interaction of drugs with HSA. It can bind to cancer drugs; thus, it is crucial to look at the binding characteristics of these drugs with HSA. Herein, we summarize the binding properties of some anti-cancer drugs by specifically looking into the binding site with HSA. The number of drugs binding at the Sudlow's site I situated in subdomain II A is more than the drugs binding at Sudlow's site II.

Keywords: Human serum albumin, anti-cancer drugs, distribution of drugs, pharmacokinetics, Sudlow's site II, subdomain II A.

Graphical Abstract

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