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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

尿毒症毒素对阿尔茨海默病的影响

卷 19, 期 2, 2022

发表于: 08 March, 2022

页: [104 - 118] 页: 15

弟呕挨: 10.2174/1567205019666220120113305

价格: $65

摘要

阿尔茨海默病（AD）是最常见的痴呆症的类型，它的病理学特征为老年斑和神经纤维缠结的积累。慢性肾脏疾病（CKD）在老年人口中最为常见，它与痴呆症的发生密切相关。最近流行病学和实验研究表明，CKD和AD之间有着潜在的联系，两种疾病都有着相同的风险因素组，例如：2型糖尿病和高血压。然而CKD和AD之间的联系尚不清楚。尿毒症毒素的低清除率，包括胱抑素C、胍、脂联素，这意味着CKD对AD的发病机制起作用。在这研究中，我们总结了流行病学、实验、临床研究等关于尿毒症毒素对AD的发病机制起作用的最新证据。我们阐述了突出问题和提出了尿毒症毒素与AD之间联系的发展前景。

关键词: 阿尔茨海默病，淀粉状朊，慢性肾脏疾病，炎症，tau蛋白，尿毒症毒素

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