The Association between Insomnia-Like Sleep Pattern Changes and Cognitive Dysfunction: Possible Mechanism and Therapeutic Strategy

doi:10.2174/1567205018666211207095048

摘要

睡眠障碍和认知功能障碍的患病率大幅增加，失眠和阿尔茨海默病 (AD) 是最常见的形式。大量研究已将睡眠连续性或睡眠结构的改变与双边认知障碍联系起来，但临床前 AD 中睡眠模式中断的管理可能更有益，因为 AD 无法治愈。本综述主要关注失眠症中睡眠模式的改变，并总结失眠与认知障碍之间关系的潜在途径，旨在建立某些睡眠模式变化作为认知能力下降的生物标志物，并根据研究进展的证据探索潜在的治疗靶点。

关键词: 失眠、睡眠结构、睡眠连续性、认知能力下降、阿尔茨海默病、轻度认知障碍。

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Current Alzheimer Research

Title:The Association between Insomnia-Like Sleep Pattern Changes and Cognitive Dysfunction: Possible Mechanism and Therapeutic Strategy

Volume: 18 Issue: 11

关键词: 失眠、睡眠结构、睡眠连续性、认知能力下降、阿尔茨海默病、轻度认知障碍。

摘要: The prevalence of sleep disorders and cognitive dysfunction has overwhelmingly increased, with insomnia and Alzheimer’s disease (AD) being the most common form. A multitude of studies have linked the alterations in sleep continuity or sleep architecture with cognitive impairment bilaterally, but the management of disrupted sleep patterns in preclinical AD could be more beneficial since there is no cure for AD. This review mainly focuses on the altered sleep patterns in insomnia, and summarizes potential pathways underlying the relationship between insomnia and cognitive impairment, aiming to establish certain sleep pattern changes as biomarkers for cognitive decline and explore potential therapeutic targets based on evidence from research advances.

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Cite this article as:

The Association between Insomnia-Like Sleep Pattern Changes and Cognitive Dysfunction: Possible Mechanism and Therapeutic Strategy, Current Alzheimer Research 2021; 18 (11) . https://dx.doi.org/10.2174/1567205018666211207095048

DOI https://dx.doi.org/10.2174/1567205018666211207095048	Print ISSN 1567-2050
Publisher Name Bentham Science Publisher	Online ISSN 1875-5828