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Review Article

吡喃并吲哚类药物综述

卷 29, 期 21, 2022

发表于: 13 January, 2022

页: [3667 - 3683] 页: 17

弟呕挨: 10.2174/0929867328666211206111058

价格: $65

摘要

大量含氮杂环化合物普遍存在于天然产物、药物和生物活性分子中。其中，吡喃吲哚是一个重要的结构基序，因为它是生物活性天然产物和治疗剂中的中心亚基。塔拉嗜热菌素、诺托酰胺、诺吉胺、卡尼酰胺和维西卡胺是天然存在的吡喃吲哚的例子，而众所周知的依托度酸和培美酸是一种四氢吡喃[3,4-b]吲哚，它源自合成过程。除了众所周知的抗炎和纤溶活性外，吡喃吲哚骨架分子还表现出多种生物活性，如抗溃疡、抗抑郁、镇痛和抗增殖等生物活性。在此，我们讲述了最常见的含有吡喃吲哚核的天然和合成产物以及它们的合成和生物活性。

关键词: 吡喃吲哚、依托度酸、培美酸、异戊烯基化吡喃吲哚类生物碱、天然吡喃吲哚、合成吡喃吲哚

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