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Mini-Review Article

Combretastatin Derivatives as Microtubule Inhibitors of Colchicines Binding Site

Author(s): Adarsh Sahu*

Volume 20, Issue 3, 2022

Published on: 26 April, 2022

Article ID: e191121198115 Pages: 9

DOI: 10.2174/2211352519666211119090754

Price: $65

Abstract

The colchicine binding site in microtubules is the most flourishing target for anticancer treatment. Microtubule inhibitor drugs, including paclitaxel and vinca alkaloids, have been considered to exert their activity primarily by increasing or decreasing the cellular microtubule mass. This review describes the microtubular assembly along with the combretastatin derivatives as microtubules inhibitors, the structures of compounds known to interact with colchicines binding sites, and their possible mechanism of action. Additionally, the utility of other heterocyclic rings and their combretastatin derivatives in treating cancer is also discussed. Colchicines binding site represents a stimulating new molecular target in the design of combretastatin drugs.

Keywords: Combrestatin, colchicine, microtubules, anticancer, aplha-tubulin, betatubulin.

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