摘要
背景:腹主动脉瘤(AAAs)是老年人因主动脉破裂死亡的主要原因。目前还没有有效的药物治疗AAA,手术是唯一可接受的治疗方法。在AAA诊断和通过矫正手术治疗之间经常有一段较长的时间,在此期间有效的药物治疗可以预防或延迟AAA修复的需要。目的:对植物化学物质在防治AAA中的潜在作用进行综述。 方法:对AAA模型和患者中植物化学物质的体外、体内和人体研究进行了总结。 结果:姜黄素、黄芪、葡萄籽多酚、白藜芦醇、银杏叶提取物(egb761)、人参皂苷Rb1、丹红、表没食子儿茶素-3-没食子酸酯、黄芩素、褐藻多糖、槲皮素、丹酚酸等是治疗AAA的潜在药物。 结论:实验在体内和体外研究显示的潜在好处一些草药和植物化学物质在预防或减少AAA的进展。为了评估是否可以翻译成证实这些发现治疗,充分设计双盲随机临床试验需要。
关键词: 腹主动脉瘤,氧化应激,植物治疗,炎症,植物药物,植物化学物质。
Current Medicinal Chemistry
Title:Potential Benefits of Phytochemicals for Abdominal Aortic Aneurysm
Volume: 28 Issue: 41
关键词: 腹主动脉瘤,氧化应激,植物治疗,炎症,植物药物,植物化学物质。
摘要:
Background: Abdominal aortic aneurysms (AAAs) are a leading cause of death in older adults due to aortic rupture. There are currently no effective medical therapies for AAA, with surgery being the only acceptable treatment. There is frequently an extended period between AAA diagnosis and treatment by corrective surgery, during which an effective drug therapy could prevent or delay the need for AAA repair. Objective: This review aimed to critically summarize prior research investigating the potential benefits of phytochemicals in preventing or treating AAA.
Methods: In vitro, in vivo, and human studies examining the effect of phytochemicals in AAA models and patients were critically summarised.
Results: Some preliminary data support the further investigation of curcumin, radix astragali, grape seed polyphenols, resveratrol, Ginkgo biloba extract (EGb 761), Ginsenoide Rb1, Dan Hong, Epigallocatechin-3-gallate, Baicalein, Fucoidan, Quercetin, and Salvianolic acid as potential treatments for AAA.
Conclusion: Experimental in vivo and in vitro studies suggest the potential benefits of a number of medicinal herbs and phytochemicals in preventing or reducing the progression of AAA. In order to assess whether these findings can be translated into proven treatments, adequately designed double-blind randomized clinical trials will be required.
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Cite this article as:
Potential Benefits of Phytochemicals for Abdominal Aortic Aneurysm, Current Medicinal Chemistry 2021; 28 (41) . https://dx.doi.org/10.2174/0929867328666210614113116
DOI https://dx.doi.org/10.2174/0929867328666210614113116 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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