The β and γ Classes of Carbonic Anhydrase

Title: The β and γ Classes of Carbonic Anhydrase

Volume: 14 Issue: 7

Author(s): S. A. Zimmerman and J. G. Ferry

Affiliation:

Abstract: There are currently five (α,β,γ,δ,Ezgr;) classes of carbonic anhydrases (CAs) of which the α-class from mammalian sources has been studied to a much greater extent compared to the other four classes. Yet, CAs other than the α-class are widely distributed in Nature and play important roles in human health, the global carbon cycle, and industrial applications. In aerobic prokaryotes, β-class CAs are implicated in maintaining internal pH and CO2/bicarbonate balances required for biosynthetic reactions. In anaerobic prokaryotes, β- class CAs are implicated in the transport of CO2 and bicarbonate across the cytoplasmic membrane that regulates pH and facilitates acquisition of substrates and product removal required for growth. In phototrophic organisms, β-class CAs are particularly important for transport and concentration of CO2 and bicarbonate for photosynthesis. The δ- and ζ-classes are proposed to function in marine diatoms to concentrate CO2 for photosynthesis. Physiological roles for the γ-class are not as well documented; however, the active site architecture and catalytic mechanism is well understood as are patterns of inhibition by sulfonamides and anions.

Cite this article as:

Zimmerman A. S. and Ferry G. J., The β and γ Classes of Carbonic Anhydrase, Current Pharmaceutical Design 2008; 14 (7) . https://dx.doi.org/10.2174/138161208783877929