正常认知，轻度认知障碍和痴呆的墨西哥裔美国人样本中神经丝光（NfL）与认知能力的关系

Title:Relationship of Neurofilament Light (NfL) and Cognitive Performance in a Sample of Mexican Americans with Normal Cognition, Mild Cognitive Impairment and Dementia

Volume: 17 Issue: 13

关键词: 神经丝轻，墨西哥裔美国人，认知过程，正常认知，MCI，痴呆。

摘要:

Introduction: This study characterized the relationship between plasma NfL and cognition in a community-based sample of older Mexican Americans.

Methods: 544 participants completed a battery of neuropsychological tests and were diagnosed using clinical criteria. NfL was assayed using Simoa. NfL levels across groups and tests were analyzed.

Results: Difference in NfL was found between normal and impaired groups and was related to global cognition, processing speed, executive functions and a list of learning tasks with a significant negative effect for all diagnostic groups. NfL had a negative impact on processing speed, attention, executive functions and delayed and recognition memory for both normal and MCI groups.

Conclusion: The research supports plasma NfL as a marker of cognitive impairment related to neurodegenerative processes in Mexican Americans and may be a marker of early changes in cognition in those with normal cognition and at risk for developing MCI.

Cite this article as:

Relationship of Neurofilament Light (NfL) and Cognitive Performance in a Sample of Mexican Americans with Normal Cognition, Mild Cognitive Impairment and Dementia, Current Alzheimer Research 2020; 17 (13) . https://dx.doi.org/10.2174/1567205018666210219105949