Mesenchymal Stromal Cell Secretome: Immunomodulation, Tissue Repair and Effects on Neurodegenerative Conditions

Title:Mesenchymal Stromal Cell Secretome: Immunomodulation, Tissue Repair and Effects on Neurodegenerative Conditions

Volume: 16 Issue: 6

Author(s): Fatima Zriek, John A. Di Battista and Nada Alaaeddine*

Affiliation:

• Neuroscience Research Center, Faculty of Medical Sciences, Lebanese University, Beirut,Lebanon

Keywords: Mesenchymal stromal cells, secretome, conditioned medium, inflammation, regeneration, neurodegenerative diseases.

Abstract: Mesenchymal stromal cells (MSCs) have emerged as a modern development in therapeutics for a wide variety of diseases. Secreted paracrine factors constitute the principal components harboring the restorative promise of MSCs. Recent studies demonstrate that MSC-derived secretomes are composed of several molecules targeting a variety of biological processes that impact tissue repair, growth and immunomodulation. Indeed, secretomes interact with immune cells, activating regulatory anti-inflammatory phenotypes. In this review, we discuss the action of MSC-derived secretomes in promoting tissue regeneration, opposing the inflammatory response in context-specific cases, and treating neurodegenerative diseases, resulting from chronic neuroinflammation.

Cite this article as:

Zriek Fatima, Di Battista A. John and Alaaeddine Nada *, Mesenchymal Stromal Cell Secretome: Immunomodulation, Tissue Repair and Effects on Neurodegenerative Conditions, Current Stem Cell Research & Therapy 2021; 16 (6) . https://dx.doi.org/10.2174/1574888X16666210202145639