Prospects of Antiviral Drugs Derived from Natural Products: Targeting SARS-CoV Entry and Replication

Title:Prospects of Antiviral Drugs Derived from Natural Products: Targeting SARS-CoV Entry and Replication

Volume: 7 Issue: 5

Author(s): Tsuey Ning Soon, Wei Hsum Yap, Ya Chee Lim, Chiau Ming Long, Bey Hing Goh*Yin-Quan Tang*

Affiliation:

• College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058,China

• School of Biosciences, Faculty of Medical and Health Sciences, Taylor’s University, 47500 Subang Jaya, Selangor Darul Ehsan,Malaysia

Keywords: COVID-19, SARS-CoV-2, 2019-nCoV, SARS-CoV, MERS-CoV, natural products, antiviral drugs, traditional Chinese medicine

Abstract: The recent coronavirus disease (COVID-19) pandemic outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its rapid spread from continent to continent pose a global health emergency. Researchers are making headway to combat the ongoing COVID-19 to prevent further losses. Many natural antiviral compounds have been explored for their potential application in treating viral infections, including those caused by SARS- and MERS-CoV. This review focuses on natural compounds that have been showing promising results against SARS-CoV, SARS-CoV-2 and MERS-CoV, along with their mechanism of action. The entry and replication of CoV are among the major mechanism for the spread of COVID-19. In this context, natural compounds inhibiting the proteins essential for SARS-CoV-2 entry and replication in the nanomolar (nicotianamine) and micromolar (baicalin, baicalein, scutellarein, dihydromyricetin, quercetagetin, myricetin, amentoflavone, herbacetin, isobavachalcone, quercetin 3‐β‐d‐glucoside, helichrysetin, hirsutenone, hirsutanonol, oregonin, rubranol, rubranoside B, rubranoside A, tanshinones, emodin, and griffithsin) concentration could be potential sources of new anti-SARS-CoV-2 drugs.

Cite this article as:

Soon Ning Tsuey , Yap Hsum Wei, Lim Chee Ya , Long Ming Chiau , Goh Hing Bey *, Tang Yin-Quan *, Prospects of Antiviral Drugs Derived from Natural Products: Targeting SARS-CoV Entry and Replication, Current Traditional Medicine 2021; 7 (5) : e220121190624 . https://dx.doi.org/10.2174/2215083807666210122151039