Accelerator Production of Scandium Radioisotopes: Sc-43, Sc-44, and Sc-47

Title:Accelerator Production of Scandium Radioisotopes: Sc-43, Sc-44, and Sc-47

Volume: 14 Issue: 4

Author(s): Margarita Chernysheva, Shaun C. Loveless, Tom Brossard, Kaelyn Becker, Shelbie Cingoranelli, Eduardo Aluicio-Sarduy, Jeongseong Song, Paul Ellison, Jerry Nolen, David A. Rotsch, Suzanne E. Lapi and Jonathan W. Engle*

Affiliation:

• Departments of Medical Physics and Radiology, University of Wisconsin Madison B1303 WIMR Cyclotron Laboratory, 1111 Highland Avenue, Madison WI 53705,United States

Keywords: Scandium, cross-section, therapeutic radioisotopes, theranostics, PET, radioisotope production, radiochemical separation, radiometal, SPECT, radiolabeling.

Abstract: Scandium radioisotopes are increasingly considered viable radiolabels for targeted molecular imaging (Sc-43, Sc-44) and therapy (Sc-47). Significant technological advances have increased the quantity and quality of available radioscandium in the past decade, motivated in part by the chemical similarity of scandium to therapeutic radionuclides like Lu-177. The production and radiochemical isolation techniques applied to scandium radioisotopes are reviewed, focusing on charged particle and electron linac initiated reactions and using calcium and titanium as starting materials.

Cite this article as:

Chernysheva Margarita , Loveless C. Shaun , Brossard Tom , Becker Kaelyn , Cingoranelli Shelbie , Aluicio-Sarduy Eduardo , Song Jeongseong , Ellison Paul , Nolen Jerry , Rotsch A. David , Lapi E. Suzanne and Engle W. Jonathan *, Accelerator Production of Scandium Radioisotopes: Sc-43, Sc-44, and Sc-47, Current Radiopharmaceuticals 2021; 14 (4) . https://dx.doi.org/10.2174/1874471014999210112205535