Peptide-Modified Nanoparticles for Tumor Targeting and Molecular Imaging

doi:10.2174/0929867327666201022122131

摘要

纳米颗粒在肿瘤靶向和分子成像方面具有广阔的前景，因为它们可以将治疗药物和成像剂与单个实体共同递送到肿瘤部位。用配体修饰的纳米颗粒由于其主动靶向机制而受到越来越多的关注。肽非常适合纳米颗粒靶向修饰，因为它们体积小、易于合成且通常无免疫原性。在此，我们根据肽靶向配体的分类综述了用于肿瘤靶向治疗和分子成像的肽修饰纳米颗粒。还将讨论靶向肽和纳米颗粒的开发。

关键词: 肽、纳米粒子、肿瘤、治疗、分子成像、肿瘤靶向。

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Current Medicinal Chemistry

Title:Peptide-Modified Nanoparticles for Tumor Targeting and Molecular Imaging

Volume: 28 Issue: 31

关键词: 肽、纳米粒子、肿瘤、治疗、分子成像、肿瘤靶向。

摘要: Nanoparticles hold great promise in tumor targeting and molecular imaging because they can co-deliver therapeutic drugs and imaging agents to the tumor site with a single entity. Nanoparticles modified with ligands against moieties overexpressed on tumor tissues have gained increasing attention due to their active targeting mechanisms. Peptides are well suited for nanoparticle targeting modifications because they are small, easy to synthesize and typically non-immunogenic. Herein, we review the peptide-modified nanoparticles used for tumor targeting therapy and molecular imaging based on the classification of peptide-targeting ligands. The development of targeting peptides and nanoparticles will also be discussed.

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Peptide-Modified Nanoparticles for Tumor Targeting and Molecular Imaging, Current Medicinal Chemistry 2021; 28 (31) . https://dx.doi.org/10.2174/0929867327666201022122131

DOI https://dx.doi.org/10.2174/0929867327666201022122131	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X