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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

APOE基因型分层后多基因危害与阿尔茨海默氏病标志物之间的关联

卷 17, 期 7, 2020

页: [667 - 679] 页: 13

弟呕挨: 10.2174/1567205017666201006161800

价格: $65

摘要

背景：研究表明，阿尔茨海默氏病风险的多基因指标与临床特征有关。 目的：鉴于APOE基因的“遗传中心性”，我们测试了APOE-ε4携带者和非携带者是否都正确。 方法：从阿尔茨海默氏病神经影像学计划中招募的784名非痴呆参与者中提取多基因危险评分（PHS），并按APOEε4身份进行分层。将数据集分为由临床（未配对/ MCI）和淀粉样蛋白状态（Aβ+ /Aβ-）定义的子队列。在每个子队列中针对每种APOE-ε4状态设计了线性模型，以测试PHS与记忆力，执行功能和灰分体积图之间的关联。 结果：PHS预测ε4ε3MCI患者的记忆力和执行功能，ε3ε3MCI患者的记忆力和ε4ε3Aβ+参与者的记忆力。 PHS还预测了ε3ε3Aβ+参与者的感觉运动区域的体积。 结论：多基因危害与神经认知变量之间的联系因APOE-ε4等位基因状态而异。这表明临床表型可能受到复杂遗传相互作用的影响。

关键词: 轻度认知障碍，载脂蛋白，记忆力，执行功能，多基因性状，淀粉样蛋白。

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