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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

老年人循环胆固醇水平与认知功能和轻度认知障碍的关联：一项基于社区的人口研究

卷 17, 期 6, 2020

页: [556 - 565] 页: 10

弟呕挨: 10.2174/1567205017666200810165758

价格: $65

摘要

背景：本研究旨在检查非痴呆社区老龄成年人中循环胆固醇与认知功能的关系。 方法：这是一项横断面研究，纳入了1754名55-80岁的中国成年人。检查血清胆固醇水平与认知功能之间的关联。根据循环TC（总胆固醇），高密度脂蛋白胆固醇（HDL-c），低密度脂蛋白胆固醇（LDL-c）水平和HDLc / LDL-c之比的四分位数将参与者分为四组。比较各组之间的认知表现差异。使用Logistic回归模型确定循环胆固醇水平与轻度认知障碍（MCI）风险的关联。 结果：血清LDL-c水平的轻度升高与更好的视觉和执行力，语言，记忆力和延迟回忆能力有关。发现较高的循环TC和HDL-c水平与较差的认知功能有关，尤其是在衰老的女性受试者中。较高的循环TC，HDL-c和HDL / LDL比表明发生MCI的风险增加，尤其是在女性受试者中。 结论：循环中LDL-c水平的轻微升高可能有益于老年人的认知功能。但是，较高的循环TC和HDL-c水平可能表明认知功能下降，尤其是在老年女性受试者中。

关键词: 胆固醇，认知，老年人，老年病，轻度认知障碍，心血管疾病。

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