Recent Applications of Benzimidazole as a Privileged Scaffold in Drug Discovery

Title:Recent Applications of Benzimidazole as a Privileged Scaffold in Drug Discovery

Volume: 21 Issue: 11

Author(s): Yongzhen Guo, Xuben Hou*Hao Fang*

Affiliation:

• Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 Wenhuaxi Road, 250012, Jinan, Shandong,China

• Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 Wenhuaxi Road, 250012, Jinan, Shandong,China

Keywords: Benzimidazole, privileged scaffold, anti-cancer, pharmacological applications, drug discovery, antiallergic.

Abstract: Benzimidazole is an aromatic bicyclic heterocycle that is regarded as a valuable privileged scaffold in medicinal chemistry. Many marketed drugs and natural products containing benzimidazole scaffolds exert great influence in fighting various diseases, such as hypertension, peptic ulcers, parasitic infections, and cancer. In this review, we introduce the pharmacological applications of some marketed drugs and lead compounds with a focus on anticancer agents, reporting the corresponding data to show the biological activities at their targets. The publications in this review encompass those from 2014 to 2019.

Cite this article as:

Guo Yongzhen , Hou Xuben *, Fang Hao *, Recent Applications of Benzimidazole as a Privileged Scaffold in Drug Discovery, Mini-Reviews in Medicinal Chemistry 2021; 21 (11) . https://dx.doi.org/10.2174/1389557520666200804124924